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Ask the Experts


When I was depressed, my doctor prescribed bupropion for me. She is now thinking of adding zolpidem. Do these two medications go together?

Answered by: David Kahn

Bupropion, also known as Wellbutrin, is an excellent antidepressant. It tends to be stimulating, so it is taken in the morning or early afternoon but usually not at bedtime. As depression improves, sleep for most people taking it normalizes, but sometimes it can cause insomnia. It certainly will not work quickly to relieve insomnia if that is a big problem at the start of treatment. Therefore, many doctors combine bupropion with a sleeping pill, at least early in treatment. Zolpidem, or Ambien, is a perfectly reasonable choice and poses no special interactions to worry about.