I suffer severely from anxiety/derealization, which is terrifying. I am on Luvox CR for OCD and it's working well. Which booster do you recommend to potentiate the anti-anxiety components of Luvox? I have been tested for seizures, which were ruled out but had excellent, though short-lived, relief from Depakote, Topomax and Lyrica. I have had a trial of 50mg Anafranil. How to reduce my derealization and anxiety?
The answer to this question is not simple. Diagnosis is the place to start, and it sounds like there has been a careful effort to rule out seizures. Other unlikely but treatable causes of anxiety, such as thyroid disease, should be ruled out with blood tests.
Anxiety/derealization can often be part of panic disorder. When panic disorder is not effectively treated by Luvox-type medicines, other classes including tricyclics (anafranil is an example) or benzodiazepines like clonazepam (klonopin) can be helpful. Cognitive-behavioral therapy can also be highly effective.
Another potentially important piece of information you give is the "excellent but short-lived relief" from several medications. I would carefully consider whether these medications were given a full try, with adequate dose and duration of treatment.