I am on the drug amisulperide (Solian). My psychiatrist has advised me to reduce from 200 mg to 150mg. However, I'm concerned because I read that low doses of Solian cause an increase of dopamine in the brain. So are low doses suitable for someone with my illness?
Meta analysis suggests that amisulpride is among the more efficacious antipsychotics. The recommended doses for someone in the acute stage of illness is 400-800 mg, although lower doses (50-300) have been shown to be helpful for maintenance treatment and possibly for negative symptoms. While lower doses (~10 mg/kg) seem to increase dopamine in preclinical experiments (Di Giovanni G et al.J Pharmacol Exp Ther. 1998; 287(1):51-7.). I am aware of only a few reports of mania induced by low dose amisulpride.