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Question:

Is it possible to combine alprazolam and melatonin for treating sleeping disturbances?

Answered by: Philip Muskin

Can one combine these substances? Yes. The underlying question is what to do if insomnia does not respond to alprazolam? This is an anxiolytic, not a hypnotic. It can be used to treat insomnia, but that is not the indication for the medication. In general medications that work for anxiety cannot be too sedating or they interfere with daily function. As such, anxiolytic medications may not be all that helpful for insomnia in some people. Thus I would not add melatonin to alprazolam bout would suggest speaking to a psychiatrist about the insomnia and reconsidering the use of the alprazolam as a hypnotic.