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Yoshifumi Naka, MD, PhD

Positions and Appointments

2012-present  Professor of Surgery
Columbia University College of
Physicians & Surgeons, New York, NY
2003-present  Director, Cardiac Transplantation Program
Columbia University Medical Center,
New York, NY
2001-present  Director, Mechanical Circulatory Support Program
Columbia University Medical Center,
New York, NY
1999-present  Attending Surgeon
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY

Clinical Specialties

Adult cardiac surgery for coronary artery disease

Valvular heart disease

Heart transplantation

Mechanical circulatory support device implantation

Research Interests

Cardiac and pulmonary transplantation

Organ preservation

Surgical treatment of atrial fibrillation

Vein graft disease after bypass surgery

Outcomes of clinical mechanical circulatory support device surgery and heart transplantation


Education and Training

1996-1998  Visiting Clinical Fellowship, Cardiothoracic Surgery
Columbia University Medical Center, New York, NY
1993-1996  Research Fellowship,
Cardiac and Pulmonary Transplantation
Columbia University Medical Center, New York, NY
1993  Fellowship, Cardiovascular Surgery
Osaka Police Hospital, Japan
1991  Residency
Osaka Police Hospital, Japan
1989  Research and Clinical Fellowship
Osaka University Medical School, Japan
1988  PhD
Osaka University Graduate School of Medicine, Japan
1984  MD
Osaka University Medical School, Japan

Professional Experience

2001-2012   Associate Professor of Surgery
Columbia University College of Physicians & Surgeons, New York, NY
1998-1999  Junior Attending Surgeon
Columbia University Medical Center, New York, NY

Professional Honors

Cournand and Comroe Young Investigator Award, American Heart Association, 1995

Young Investigators Award, Japanese Association of Thoracic Surgery, 1988

Professional Societies and Committees

MEMBERSHIPS
American Association for Thoracic Surgery
American Heart Association,
Councils of Circulation and Cardiothoracic Surgery
American Society for Artificial Internal Organs
American Society of Transplant Surgeons
International Society for Heart and Lung Transplantation
Japanese Association for Thoracic Surgery
Japanese Circulation Society
Japan Surgical Society
New York Society of Thoracic Surgery
Society of Thoracic Surgeons
Society of University Surgeons

OTHER PROFESSIONAL ACTIVITIES
Co-Chair, Satellite Symposium 3 “Current trends in mechanical assistance: Role of destination therapy” at the annual meeting of the International Society for Heart and Lung Transplantation, San Francisco, USA, 2004

Co-Chair, "Featured Research Session" at the annual meeting of the Japanese Circulation Society, Sapporo, Japan, 2002

Co-Chair, "More VADs go bad," at the annual meeting of the International Society for Heart and Lung Transplantation, Vancouver, 2001

Chair, "A issue in device immunology", at the annual meeting of the World Artificial-Organ, Immunology, and Transplantation, Ottawa, 2001

Chair, "Device patient interaction" at the International Heart and Lung Transplantation 3rd Fall Education Meeting, Mechanical Circulatory Support and Replacement II, Anaheim, 2001

Guest Editor, Ann Thoracic Surg 71 (suppl); Proceedings of the Fifth International Conference on Circulatory Support Devices For Severe Cardiac Failure. New York, NY, 9/15-17/00


Research Abstracts


Please click abstract title to read full text.

Axial Flow LVADs Are Associated with Fewer Device-Related Infections Than Pulsatile LVADs


Current Projects


"Recovery of the Left Ventricle During Left Ventricular Assist Devices Support" - Foundation for Advancement in Cardiothoracic Surgery


Current Clinical Trials


HeartMate II bridge to transplant feasibility trial - Study measuring feasibility and safety of implanting a small axial flow left ventricular assist device to treat patients awaiting heart transplantation. Thoratec Co.

MicroMed DeBakey VAD bridge to transplant pivotal trial - Study measuring effectiveness of implanting another small axial flow left ventricular assist device to treat patients awaiting heart transplantation. MicroMed, Inc.

MicroMed DeBakey VAD Destination Therapy trial - Study measuring effectiveness of implanting a small axial flow left ventricular assist device to treat patients with chronic end-stage heart failure who are not transplant candidates.

PREVENT-IV trial - Treatment of vein graft disease using E2F decoy in coronary artery bypass graft patients (Enrollment completed).

Impella feasibility trial - Study measuring feasibility and safety of inserting an minimal invasive small axial flow left ventricular assist device to treat patients in acute cardiogenic shock.


Completed Projects


"Vein Graft Preservation: Thrombosis & Neointimal Disease" - K08 award 2001 NIH/NHLBI





Selected Publications

Wasson LT, Yuzefpolskaya M, Wakabayashi M, Takayama H, Naka Y, Uriel N, Jorde UP, Demmer RT, Colombo PC. Heart Fail Rev. Epub, 2014.

Takeda K, Takayama H, Kalesan B, Uriel N, Colombo PC, Jorde UP, Naka Y. Long-term outcome of patients on continuous-flow left ventricular assist device suppot. J Thorac Cardiovasc Surg. 148: 1606-1614, 2014.

Khawaja T, Chokshi a, Ji R, Kato TS, Xu K, Zizola C, Wu C, Forman DE, Ota T, Kennel PJ, Takayama H, Naka Y, George I, Mancini D, Schulze PC. Erratum to: ventricular assist device implantation improves skeletal muscle function, oxidative capacity, and growth hormone/insulin-like growth factor-1 axis signaling in patients with advanced heart failure. J Cachexia Sarcopenia Musle 2014. Epub.

Landes E, Naka Y, Takeda K, Takayama H. Single center experience with a minimally invasive apicoaxillary external left ventricular assist device. J Thorac Cardiovasc Surg. 2014. Epub.

Khawja T, Chokshi A, Ji R, Kato TS, Xu K, Zizola C, Wu C, Forman DE, Ota T, Kennel P, Takayama H, Naka Y, George I, Mancini D, Schulze CP. Ventricular assiste device implantation improves skeletal muscle function, oxidative capacity, and growth hormone/insulin-like growth factor-1 axis signaling in patients with advanced heart failure. J Cachexia Sarcopenia Muscle. 2014. Epub.

Fried J, Levin AP Mody KM, Garan AR, Yuzefpolskaya M, Takayama H, Diuguid DL, Naka Y, Jorde U, Uriel N. Prior hematologic conditions carry a high morbidity and mortality in patients supported with continuous flow left ventricular assist devices. J Heart Lung Transplant. 2014 Epub.

Pronschinske KB, Qiu S, Wu C, Kato TS, Khawaja T, Takayama H, Naka Y, Templeton DL George I, Farr MA, Mancini DM, Christian Schulze P. Neutrophil gelatinase- associated lipocalin and cystatin C for the prediction of clinical events in patients with advanced heart failure and after ventricular assist device placement. J Heart Lung Transplant. 2014 Epub.

Takayama H, Soni L, Kalesan B, Truby LK, Ota T, Cedola S, Khapley Z, Uriel N, Colombo P, Mancini DM, Jorde UP, Naka Y. Bridge-to-decision therapy with a continuous flow external ventricular assist device in refractory cardiogenic shock of various etiologies. Circ Heart Fail. 2014, Epub.

Uriel N, Numi N, Colombo PC, Yuzefpolskaya M, Restaino SW, Han J, Thomas SS, Garan AR, Takayama H, Mancini DM, Naka Y, Jorde UP. Advanced heart failure in patients infected with human immunodeficiency virus: Is there equal access to care? J Heart Lung Transplant 2014. Epub.

Moazami N, Steffen RJ, Naka Y, Norde U, Bailey S, Murali S, Camacho MT, Zucker M, Marascalco PJ, Rao V, Feldman D; SUSTANI investigators. Lessons learned from the first fully magnetically levitated centrifugal LVAD trial in the United States: The DuraHeart Trial. Ann Thorac Surg 2014. Epub.

Thomas SS, Naumi N, Han J, Lippel M, Colombo P, Yuzefpolskaya M, Takayama H, Naka Y, Uriel N, Jorde P. Pre-operative mortality risk assessment in patients with continuous-flow left ventricular assist devices: Application of the HeartMate II risk score. J Heart Lung Transplant 2014. Epub.

Ascheim DD, Gelijns AS, Goldstein D, Moye LA, Smedila N, Lee S, Klodell CT, Szady A, Parides MK, Jeffries NO, Skerrett D, Taylor DA, Rame JE, Milano C, Rogers JG, Lynch J, Dewey T, Eichhorn E, Sun B, Feldman D, Simari R, O’Gara PT, Taddei-Peters WC, Miller MA, Naka Y, Begiella E, Rose EA, Woo YJ. Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. Circulation 2014. 129:2287-2296.

Kato TS, Lippel M, Naka Y, Mancini DM, Schulze PC. Post-transplant survival estimation using pre-operative albumin levels. J Heart Lung Transplant 2014. 33:547-548.

Kato TS, Jiang J, Schulze PC, Jorde U, Uriel N, Kitada S, Takayama H, Naka Y, Mancinic D, Gillam L, Homma S, Farr M. Serial echocardiography using tissue Doppeler and speckle tracking imaging to monitor right ventricular failure before and after left ventricular assist device surgery. JACC Heart Fail. 2013. 1: 216-222.

Garan AR, Iyer V, Whang W, Mody KP, Yuzefpolskaya M, Colombo PC, Te-Frey R, Takayama H, Naka Y, Garan H, Jorge UP, Uriel N. Catheter ablation for ventricular tachyarrhythmias in patients supported by continuous flow left ventricular assist devices. ASAIO J. 2014. Epub.

Jorde UP, Kushwaha SS, Tatooles AJ, Naka Y, Bhat G, Long JW, Horstmanshof DA, Kormos RL, Teuteberg JJ, Slaughter MS, Birks EJ, Farrar DJ, Park SJ; HeartMate II Clinical Investigators. Results of the destination therapy post-FDA-approval study with a continuous flow left ventricular assist device: A prospective study using the INTEWMACS Registry. J Am Coll Cardiolol. 2014. Pii:S0735-1097.

Morrison KA, Jorde UP, Garan AR, Takayama H, Naka Y, Uriel N. Acquired von Willebrand disease during CentriMag support is associated with high prevalence of bleeding during support and after transition to heart replacement therapy. ASAIO J. 2014. 60: 241-242.

Chung CJ, Wu C, Jones M, Kato TS, Dam TT, Givens R, Templeton DL, Maurer MC, Naka Y, Takayama H, Mancini DM, Schulze PC. Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement. J Card Fail. 2014. Pii: S1071-9164.

Mody KP, Takayama H, Landes E, Yuzefpolskaya M, Colombo PC, Naka Y, Jorde UP, Uriel N. Acute mechanical circulatory support o fulminant myocardiogenic shock. J Cardiovasc Transl Res. 201. 7:156-64.

Nishimura T, Ota T, Takayama H, Naka Y. Extended trans-septal and left atrial dome incision combined with Manouguian’s aortotomy for complex double valve surgery. Eur J Cardiothoracic Surg. 2014. Epub.

Fried J, Han J, Naka Y, Jorde UP, Uriel N. Myocardial infarction after left ventricular assist device implantation: clinical course, role of aortic root thrombus, and outcomes. J Heart Lung Transplant. 2014. 33:112-115.

John R, Naka Y, Park SJ, Sai-Sudhakar C, Salerno C, Sundareswaran KS, Farrar DJ, Milano CA. Impact of concurrent surgical valve procedures in patients receiving continuous-flow devices. J Thoratec Cardiovasc Surg. 2014. 147:581-589.

Jorde UP, Uriel N, Nahumi N, Bejar D, Gonzalez-Constello J, Thomas SS, Han J, Morrison KA, Jones S, Kodali S, Hahn RT, Shames S, Yuzefpolskaya M, Colombo P, Takayama H, Naka Y. Prevalence, significance, and management of aortic insufficiency in continuous flow left ventricular assist device recipients. Circ Heart Fail. 2014. Epub.

Uriel N, Han J, Morrison KA, Naumi N, Yuzefpolskaya M, Garan AR, Duong J, Colombo PC, Takayam H, Thomas S, Naka Y, Jorde UP. Device thrombosis in HeartMate II continuous-flow left ventricular assist devices: A multifactorial phenomenon. J Heart Lung Transplant. 2013. Epub.

Takeda K, Naka Y, Yang JA, Uriel N, Colombo PC, Jorde UP, Takayama H. Timing of temporary right ventricular assist device insertion for severe right heart failure after left ventricular assist device implantation. ASAIO J. 2013. 59:564-569.

Wang DY, Kelly LA, Richmond ME, Quinn TA, Cheng B, Spotnitz MD, Cabreriza SE, Naka Y, Stewart AS, Smith CR, Spotnitz HM. Feasibility of temporary biventricular pacing after off-pump coronary artery bypass grafting in patients with reduced left ventricular function. Tex Heart Inst J. 2013: 40: 403-409.

Kato TS, Colombo PC, Nahumi N, Kitada S, Takayama H, Naka Y, Di Tullio MR, Homma S, Mancini D, Jorde UP, Uriel N. Value of serial echo-guided rump studies in a patient with suspicion of device thrombosis after left ventricular assist device implantation. Echocardiography. 2013. Epub.

Bartoli CR, Demarest CT, Khalpey Z, Takayama H, Naka Y. Current management of left ventricular assist device erosion. J Card Surg 2013. Epub.

Ota T, Yerebakan H, Akashi H, Takayama H, Uriel N, Colombo PC, Jorde UP, and Naka Y. Continuous-flow left ventricular assist device exchange: clinical outcomes. J Heart Lung Transplant. 2013. Epub.

Takeda K, Naka Y, Yang JA, Uriel N, Colombo PC, Jorde UP, Takayama H. Outcome of unplanned right ventricular assist device support for severe right heart failure after implantable left ventricular assist device insertion. J Heart Lung Transplant. 2013. Epub.

BOOK CHAPTERS
Hill JD, Farrar DJ, Naka Y, Chen JM, Portner PM, Loisance D. Positive Displacement Ventricular Assist Devices. In: Mechanical Circulatory Support. ISHLT Monograph Series. Editors. Frazier OH, and Kirklin JK. Elsevier Saunders. Pp 53-76. 2006

Dang NC, Oz MC, Naka Y. Ventricular Assist. In: Kaiser LR, Kron IL, Spray TL eds. Mastery of Cardiothoracic Surgery. 2nd edition. Lippincott Williams & Wilkins, Philadelphia, Pp 500-509, 2006.

Aggarwal S, Cheema F, Oz MC, Naka Y. Long-term Mechanical Circulatory Support. In Cohn LH ed. Cardiac Surgery in the Adult. 3rd edition. McGraw Hill Medical, New York, Pp 1609-1627. 2006

Naka Y, Rose EA. Assisted Circulation in the Treatment of Heart Failure. In Zippes, Libby, Bonow, Mann, eds Braunwald’s Heart Disease 8th ed. Philadelphia, Elsevier Saunders. 2007: pp 685-696

Morgan JA, Oz MC , Naka Y. Ventricular assist devices. In Sellke FW, del Nido PJ, Swanson SJ, eds Sabiston & Spencer Surgery of the Chest. 8th ed. Elsevier Saunders, 2010; pp1507-1524.

Sayer G, Naka Y, Jorde UP. Ventricular assist device therapy in advanced heart failure – State of the art. In Jeremias and Brown eds Cardiac Intensive Care 2nd ed. Elsevier Saunders, 2010; pp 576-585.

Takayama H, Worku B, Naka Y. Chapter 11. Postoperative Management of the patient with a Ventricular Assist Device. In: Sladen RN, Fanshawe M, editors. A Society of Cardiovascular Anesthesiologists Monograph. Postoperative Cardiac Care. Chapter 11. Wolters Kluwer/Lippincott Williams&Wilkins; 2011, p191-206.

Takayama H, Naka Y. HeartMate II. In: Matsuda H, ed. Heart Transplantation. Tokyo, Japan: Springer Japan; 2011: 4.4.5

Takayama H, Worku B, Naka Y. Chapter 66. Long-term Mechanical Circulatory Support. In: Cohn LH editor. Cardiac Surgery in the Adult, 4th edition. McGraw Hill Medical; 2012, p1353-1372

Takayama H, Yang J, Naka Y. Chapter 152. Cardiothoracic Surgery on Patients with Mechanical Circulatory Support Devices. In: Franco KL, Thourani VH, editors. Cardiothoracic Surgery Review. Wolters Kluwer/Lippincott Williams&Wilkins; 2012

Takayama H, Yang J, Naka Y. Chapter 177. Redo Heart Transplantation (Columbia Experience). In: Franco KL, Thourani VH, editors. Cardiothoracic Surgery Review. Wolters Kluwer/Lippincott Williams&Wilkins; 2012

Takayama H, Thomas S, Naka Y. Chapter 6. Transplant versus VAD: Evolving and Future Perspectives. In Shunei Kyo, editor. Ventricular assist devices in advanced-stage heart failure. Springer 2014.

BOOKS
Deng M and Naka Y. Mechanical Circulatory Support Therapy in Advanced Heart Failure. 2007. Imperial Press

Morgan J and Naka Y. Surgical Treatment of Advanced Heart Failure. 2013. Springer

(Visit PubMed to view this faculty member's most recent articles.)

LECTURES AND PRESENTATIONS
Invited lecture at the annual meeting of German Cardiothoracic Surgery, February, 2002. "Surgical treatment of atrial fibrillation. Columbia Unversity experience."

Invited lecture, “Destination Therapy” at the “Meeting Experts” session at the 40th annual meeting of the Society of Thoracic Surgeons, San Antonio, Texas.

Invited lecture, “Improving Success with the HeartMate Left Ventricular Assist Device as a Bridge to Transplant. –Columbia Experience” at the 34th annual meeting of the Japanese Society for Cardiovascular Surgery, Fukuoka, Japan.

Invited lecture, “Indication for Left Ventricular Assist Device Implantation. –Endlessly Moving Targets-” at the 22th annual meeting of the Japanese Society for Cardiac Transplantation, Fukuoka, Japan.

Keynote lecture at the 66th annual meeting of Japanese Circulation Society, April, 2002."Evolving role of mechanical circulatory assistance in the management of end-stage heart failure."

Invited lecture at Saitam Medical School Postgraduate Education Program, March, 2002."Strategy for end-stage heart failure"

(Visit PubMed to view this faculty member's most recent articles.)






Address:
NewYork-Presbyterian Hospital/Columbia
Milstein Hospital Bldg Room 7-435 GN
177 Fort Washington Avenue
New York, NY   10032

Phone: 212-305-0828
Fax: 646-426-0156


yn33@columbia.edu


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