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Yoshifumi Naka, MD, PhD

Positions and Appointments

2012-present  Professor of Surgery
Columbia University College of
Physicians & Surgeons, New York, NY
2003-present  Director, Cardiac Transplantation Program
Columbia University Medical Center,
New York, NY
2001-present  Director, Mechanical Circulatory Support Program
Columbia University Medical Center,
New York, NY
1999-present  Attending Surgeon
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY

Clinical Specialties

Adult cardiac surgery for coronary artery disease

Valvular heart disease

Heart transplantation

Mechanical circulatory support device implantation

Research Interests

Cardiac and pulmonary transplantation

Organ preservation

Surgical treatment of atrial fibrillation

Vein graft disease after bypass surgery

Outcomes of clinical mechanical circulatory support device surgery and heart transplantation


Education and Training

1996-1998  Visiting Clinical Fellowship, Cardiothoracic Surgery
Columbia University Medical Center, New York, NY
1993-1996  Research Fellowship,
Cardiac and Pulmonary Transplantation
Columbia University Medical Center, New York, NY
1993  Fellowship, Cardiovascular Surgery
Osaka Police Hospital, Japan
1991  Residency
Osaka Police Hospital, Japan
1989  Research and Clinical Fellowship
Osaka University Medical School, Japan
1988  PhD
Osaka University Graduate School of Medicine, Japan
1984  MD
Osaka University Medical School, Japan

Professional Experience

2001-2012   Associate Professor of Surgery
Columbia University College of Physicians & Surgeons, New York, NY
1998-1999  Junior Attending Surgeon
Columbia University Medical Center, New York, NY

Professional Honors

Cournand and Comroe Young Investigator Award, American Heart Association, 1995

Young Investigators Award, Japanese Association of Thoracic Surgery, 1988

Professional Societies and Committees

MEMBERSHIPS
American Association for Thoracic Surgery
American Heart Association,
Councils of Circulation and Cardiothoracic Surgery
American Society for Artificial Internal Organs
American Society of Transplant Surgeons
International Society for Heart and Lung Transplantation
Japanese Association for Thoracic Surgery
Japanese Circulation Society
Japan Surgical Society
New York Society of Thoracic Surgery
Society of Thoracic Surgeons
Society of University Surgeons

OTHER PROFESSIONAL ACTIVITIES
Co-Chair, Satellite Symposium 3 “Current trends in mechanical assistance: Role of destination therapy” at the annual meeting of the International Society for Heart and Lung Transplantation, San Francisco, USA, 2004

Co-Chair, "Featured Research Session" at the annual meeting of the Japanese Circulation Society, Sapporo, Japan, 2002

Co-Chair, "More VADs go bad," at the annual meeting of the International Society for Heart and Lung Transplantation, Vancouver, 2001

Chair, "A issue in device immunology", at the annual meeting of the World Artificial-Organ, Immunology, and Transplantation, Ottawa, 2001

Chair, "Device patient interaction" at the International Heart and Lung Transplantation 3rd Fall Education Meeting, Mechanical Circulatory Support and Replacement II, Anaheim, 2001

Guest Editor, Ann Thoracic Surg 71 (suppl); Proceedings of the Fifth International Conference on Circulatory Support Devices For Severe Cardiac Failure. New York, NY, 9/15-17/00


Research Abstracts


Please click abstract title to read full text.

Axial Flow LVADs Are Associated with Fewer Device-Related Infections Than Pulsatile LVADs


Current Projects


"Recovery of the Left Ventricle During Left Ventricular Assist Devices Support" - Foundation for Advancement in Cardiothoracic Surgery


Current Clinical Trials


HeartMate II bridge to transplant feasibility trial - Study measuring feasibility and safety of implanting a small axial flow left ventricular assist device to treat patients awaiting heart transplantation. Thoratec Co.

MicroMed DeBakey VAD bridge to transplant pivotal trial - Study measuring effectiveness of implanting another small axial flow left ventricular assist device to treat patients awaiting heart transplantation. MicroMed, Inc.

MicroMed DeBakey VAD Destination Therapy trial - Study measuring effectiveness of implanting a small axial flow left ventricular assist device to treat patients with chronic end-stage heart failure who are not transplant candidates.

PREVENT-IV trial - Treatment of vein graft disease using E2F decoy in coronary artery bypass graft patients (Enrollment completed).

Impella feasibility trial - Study measuring feasibility and safety of inserting an minimal invasive small axial flow left ventricular assist device to treat patients in acute cardiogenic shock.


Completed Projects


"Vein Graft Preservation: Thrombosis & Neointimal Disease" - K08 award 2001 NIH/NHLBI





Selected Publications

Rao V, Oz MC, Flannery MA, Catanese KA, Argenziano M, Naka Y. Revised screening scale to predict survival following left ventricular assist device insertion. J Thorac Cardiovasc Surg 125: 855-862, 2003

Williams M, Joshi N, Kavarana M, Casher J, Hankinson T, Oz MC, Naka Y, Mancini D. Insertion of a left ventricular assist device in patients without thorough transplant evaluations: A worthwhile risk? J Thorac Cardiovasc Surg 126: 436-441, 2003.

Morgan JA, Weinberg AD, Hollingsworth KW, Flannery MA, Idrissi KA, Rose EA, Oz MC, Naka Y. Effect of Gender on Successful Bridging to Transplant and Post-transplant Survival. J Thorac Cardiovasc Surg 127:1193-5, 2004

Kherani A, Cheema FH, Oz MC, Fal JM, Topkara VK, Wilson DA, Vigilance DW, Morgan JA, Garrido MJ, and Naka Y. Implantation of a left ventricular assist device and the hub-and-spoke system in treating acute cardiogenic shock: Who survives? J Thorac Cardiovasc Surg 126:1634-1635, 2003

Morgan JA, Weinberg AD, Hollingsworth KW, Flannery MR, Naka Y. Does Bridging to Transplant With a Left Ventricular Assist Device Adversely Affect Post-Transplant Survival? A Comparative Analysis of Mechanical Versus Inotropic Support. J Thorac Cardiovasc Surg 126:1188-90, 2003.

Morgan JA, John R, Rao V, Weinberg AD, Lee BJ, Mazzeo PA, Flannery MR, Chen JM, Rose EA, MD, Oz MC, Naka Y. Bridging to Transplant With the Heartmate Left Ventricular Assist Device: The Columbia Presbyterian Twelve-Year Experience. J Thorac Cardiovasc Surg 127(5):1309-16, 2004.

Morgan JA, John R, Rao V, Weinberg AD, Lee BJ, Mazzeo PA, Flannery MR, Chen JM, Rose EA, MD, Oz MC, Naka Y. Is severe right ventricular failure in LVAD recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality. Ann Thorac Surg, 77:859-63, 2004.

Yan SF, Ramasamy R, Naka Y, Schmidt AM. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 93:1159-1169, 2003.

Morgan JA, Mazzeo PA, Flannery MR, Oz MC, Naka Y. Effects of changes in UNOS policy regarding left ventricular assist devices. J Heart Lung Transplant. 23:620-622, 2004.

Lazar RM, Shapiro PA, Jaski BE, Parides MK, Bourge RC, Watson JT, Damme L, Dembitsky W, Hosenpud JD, Gupta L, Tierney A, Kraus T, Naka Y. Neurological Events During Long-Term Mechanical Circulatory Support for Heart Failure. The Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Experience. Circulation. 109: 2423-2427, 2004.

Naka Y, Bucciarelli LG, Wendt T, Lee LK, Rong LL, Ramasamy R, Yan SF, Schmidt AM. RAGE Axis. Animal Models and Novel Insights Into the Vascular Complications of Diabetes. Arterioscler Thromb Vasc Biol. 2004 May 20 [Epub ahead of print]

Fujita T, Asai T, Andrassy M, Stern DM, Pinsky DJ, Zou YS, Okada M, Naka Y, Schmidt AM, Yan SF. PKCbeta regulates ischemia/reperfusion injury in the lung. J Clin Invest 113:1615-23, 2004.

Rao V, Oz MC, Flannery MA, Idrissi KA, Argenziano M, Edwards NM, Naka Y. Changing trends in mechanical circulatory assistance. J Card Surg. 19:361-6, 2004.

Kavarana MN, Pessin-Minsley M, Uretecho J, Catanese KA, Flannery MA, Oz MC, Naka Y. Right ventricular dysfunction and organ failure in left ventricular assist device recipients: A continuing problem. Ann Thorac Surg. 73: 745-750, 2002.

Minamoto K, Pinsky DJ, Fujita T, Naka Y. Timing of nitric oxide donor supplementation determines endothelin-1 regulation and quality of lung preservation for transplantation. Am J Respir Cell Mol Biol. 26:14-21, 2002.

Barbone A, Rao V, Oz MC, Naka Y. LVAD support in patients with bioprosthetic valves. Ann Thorac Surg 74: 232-234, 2002.

Nurozler F, Argenziano M, Oz MC, Naka Y. Fungal left assist device endocarditis. Ann Thorac Surg 71:614-618, 2001.

Rao V, Oz MC, Edwards NM, Naka Y. New technique for off-pump insertion of Thoratec Right Ventricular Assist Device. Ann Thorac Surg 71:1719-1720, 2001.

Fujita Y, Toda K, Karimova A, Yan S-F, Naka Y, Pinsky DJ. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by depression of fibrinolysis. Nat Med 7:598-604, 2001.

Naka Y, Edwards NM, Oz MC. A novel technique to repair type A acute aortic dissection in patients with an implantable left ventricular assist device. Ann Thorac Surg 72(4):1403-4, 2001

Barbone A, Holmes JW, Heerdt PM, The' AHS, Naka Y, Joshi N, Daines M, Marks AR, Oz MC, Burkhoff D. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: A primary role of mechanical unloading underlying reverse remodeling. Circulation 2001 104: 670 - 675

John RJ, Rajashinghe HA, Chen JM, Weinberg AD, Sinha P, Mancini DM, Naka Y, Oz MC, Smith CR, Rose EA, Edwards NM. Long-term outcomes after cardiac transplantation: an experience based on different eras of immunosuppressive therapy. Ann Thorac Surg. 72: 440-449, 2001.

Lietz K, John R, Burke EA, Ankersmit JH, McCue JD, Naka Y, Oz MC, Mancini DM, Edwards NM. Pretransplant cachexia and morbid obesity are predictors of increased mortality after heart transplantation. Transplantation 72:277-83, 2001.

(Visit PubMed to view this faculty member's most recent articles.)

LECTURES AND PRESENTATIONS
Invited lecture at the annual meeting of German Cardiothoracic Surgery, February, 2002. "Surgical treatment of atrial fibrillation. Columbia Unversity experience."

Invited lecture, “Destination Therapy” at the “Meeting Experts” session at the 40th annual meeting of the Society of Thoracic Surgeons, San Antonio, Texas.

Invited lecture, “Improving Success with the HeartMate Left Ventricular Assist Device as a Bridge to Transplant. –Columbia Experience” at the 34th annual meeting of the Japanese Society for Cardiovascular Surgery, Fukuoka, Japan.

Invited lecture, “Indication for Left Ventricular Assist Device Implantation. –Endlessly Moving Targets-” at the 22th annual meeting of the Japanese Society for Cardiac Transplantation, Fukuoka, Japan.

Keynote lecture at the 66th annual meeting of Japanese Circulation Society, April, 2002."Evolving role of mechanical circulatory assistance in the management of end-stage heart failure."

Invited lecture at Saitam Medical School Postgraduate Education Program, March, 2002."Strategy for end-stage heart failure"

(Visit PubMed to view this faculty member's most recent articles.)






Address:
NewYork-Presbyterian Hospital/Columbia
Milstein Hospital Bldg Room 7-435 GN
177 Fort Washington Avenue
New York, NY   10032

Phone: 212-305-0828
Fax: 646-426-0156


yn33@columbia.edu


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