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Stephen Rayport, M.D./PH.D.
Associate Professor of Clinical Neuroscience
Research Psychiatrist II,
NYSPI
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Stephen Rayport, MD PhD did undergraduate work at Harvard, where he studied the evolution of vision with George Wald. He did MD-PhD training at Columbia with Eric Kandel where he studied the development of simple learning mechanisms. He trained in Psychiatry at Columbia and the NYS Psychiatric Institute. His current research focuses on the mesoaccumbens dopamine neurons that are thought to mediate the rewarding effects of abused drugs, as well as to figure importantly in the pathogenesis of schizophrenia. He has shown that these neurons release glutamate from a subset of their synapses. In transgenic mice with fluorescent dopamine neurons, he is exploring the dynamic interaction between the dopamine and glutamate release. He is using transgenic techniques to reduce or eliminate glutamatergic transmission to address the role of the glutamatergic cotransmission, and more broadly the relative contributions of different glutamatergic pathways to drug-dependent and schizophrenia-related behaviors. On the postsynaptic side, he is examining the trafficking of dopamine receptors involved in the modulation of single accumbens synapses. He is the recipient of research grants from NIDA, NIMH, and NARSAD. The guiding theme is that reversing psychostimulant-induced neuroplastic changes will provide new means to treat drug dependence and offer insight into the pathogenesis of schizophrenia.
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Undergraduate: Harvard College, BA, 1972-1975
Graduate: Columbia University, PhD, 1975-1981
Medical School: Columbia Univ. College of Physicians & Surgeons, MD, 1975-1982
Internship: Montefiore Medical Center / Albert Einstein Coll. Medicine, Internal Medicine, 1982-1983
Residency: Columbia / NYSPI, Psychiatry, 1983-1986
Fellowship: Columbia University, Dana Fellowship, 1986-1988
Board Certifications: American Board of Psychiatry and Neurology
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• Psychiatry
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Address:
NYS Psychiatric Institute
Room 3916 Unit/Box:62
1051 Riverside Drive
New York, NY 10032
Phone: 212-543-5641
Fax: 212-504-3135
Stephen.Rayport@columbia.edu
Personal Homepage
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| Animal Models of Psychiatric Disease, Synapses and Circuits
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1. Mizuno T, Schmauss C, Rayport, S: Distinct roles of presynaptic dopamine receptors in the differential modulation of the intrinsic synapses of medium-spiny neurons in the nucleus accumbens. BMC Neuroscience 2007;8: 8
2. Geldwert D, Norris JM, Feldman IG, Schulman JJ, Joyce MP, Rayport S: Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro. BMC Neuroscience 2006;7: 53
3. Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz A, Parrot S, Miller GM, Jorisch R, Polan R, Hamon M, Hen R, Rayport S: Mice lacking brain/kidney phosphate-activated glutaminase (GLS1) have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. Journal of Neuroscience 2006;26: 4660-4671
4. Zhuang X, Masson J, Gingrich JA, Rayport S, Hen R : Targeted gene expression in dopaminergic and serotonergic neurons of the mouse brain. Journal of Neuroscience Methods 2005;143: 27-32
5. Chuhma N, Zhang H, Masson J, Zhuang X, Sulzer D, Hen R, Rayport S: Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. Journal of Neuroscience 2004;24: 972-981
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FACULTY ONLY
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