Ravichandran Ramasamy, BS, PHD - Department of Surgery

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Ravichandran Ramasamy, BS, PHD

Positions and Appointments
2009-present		Associate Professor of Clinical Surgical Science (in Surgery)
		Columbia University College of Physicians & Surgeons, New York, NY

Research Interests

Metabolic mechanisms of diabetic cardiomyopathy

Mechanisms of myocardial ischemic injury

Mitochondrial signaling and cardiac cell death

Education and Training
1993-1994		Post-Graduate Researcher, Division of Cardiovascular Medicine
1993-1994		University of California-Davis, Davis, CA
1989-1993		Research Associate
1989-1993		University of Texas at Dallas/University of Texas Southwestern Medical Center, Dallas, TX
1989		Arthur Schmidt Fellow, Department of Chemistry
1989		Loyola University, Chicago, IL
1989		PhD
1989		Loyola University, Chicago, IL
1985-1989		Teaching and Research Assistant
1985-1989		Loyola University, Chicago, IL
1985		BS, Chemistry
1985		Loyola University, Madras, India

Professional Experience

2002-2009		Assistant Professor of Surgical Science
2002-2009		Columbia University College of Physicians and Surgeons, New York, NY
1997-2003		Assistant Professor of Medicine, Division of Cardiology
1997-2003		Columbia University College of Physicians & Surgeons, New York, NY
1995-1996		Adjunct Assistant Professor, Division of Cardiovascular Medicine
1995-1996		University of California - Davis, Davis, CA

Professional Honors

The Harold and Golden Lamport Award
For Excellence in Clinical Research, 2004

Established Investigator Award, American Heart Association, National Center, 2000-2003

JNICT Program, Praxis XXI Visiting Scientist,
University of Coimbra, Portugal, 1995-1996

Career Development Award, American Diabetes Association,
1994-1997

Arthur Schmidt Dissertation Fellow, Loyola University
Chicago, Illinois, 1989

First Prize in 18th Annual Graduate Student Research Forum,
Loyola Chapter of Sigma Xi, 1988

Professional Societies and Committees

Memberships, Professional Societies

American Heart Association—Council on Basic Science

American Diabetes Association

American Association for the Advancement of Science

American Physiological Society

Memberships, Committees & Review Panels

Reviewer, NIH- Center for Scientific Review, Cellular Mechanisms of Aging and Development (CMAD), February 16-18, 2004, June 7-9, 2004, October 27-29, 2004.

Reviewer, American Diabetes Association, July 2004-June 2007

Chair, Session on Polyol Pathway in Cardiovascular Pathology, International Polyol Pathway Conference, 2004, Kona, Hawaii

Member, Organizing Committee, International Polyol Pathway Conference, 2004, Kona, Hawaii

Ad Hoc Reviewer, National Institute of Aging-
Biological Sciences Study Section

Grant Reviewer, AHA Northeast, NE4 study section

Chair, Session on Aldose Reductase and Cardiac Energy Metabolism, US-Japan Aldose Reductase workshop,
Kona, Hawaii, 2000

Selected Publications

Y.C. Hwang, Kaneko M, Bakr S, Liao H, Lu Y, Lewis ER, Yan SD, Ii S, Itakura M, Rui L, Skopicki H, Homma S, Schmidt AM, Oates PJ, Szabolcs M, Ramasamy R. Central role for aldose reductase pathway in myocardial ischemic injury. FASEB Journal, 2004, 18: 1192-1199.

R. Ramasamy, Hwang YC., Liu Y, Son NH., Szabolcs MJ., Cannon PJ. Metabolic and functional protection by selective inhibition of NOS-2 during ischemia-reperfusion in isolated perfused hearts. Circulation, 2004, 109: 1668-1673.

Y.C. Hwang, S. Bakr, C.R. Ellery, P.J. Oates, Ramasamy R. Sorbitol dehydrogenase: A novel target for adjunctive protection of ischemic myocardium. FASEB Journal, 2003, 17: 2331-2333.

K. Tieu, C. Perier, C. Caspersen, P. Teismann, D. Wu, S. Yan, A. Naini, M. Vila, V. Jackson-Lewis, R. Ramasamy, S. Przedborski. D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson’s disease. Journal of Clinical Investigation 2003, 112: 892-901.

T. M. Ravindranath, M. Goto, S. Bakr, R. Ramasamy. LPS induced changes in myocardial markers in neonatal rats. Biology of the Neonate 2003, 84: 319-324.

Yan SF, Ramasamy R, Naka Y, Schmidt AM. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 2003 Dec 12;93(12):1159-69.

Hudson BI, Bucciarelli LG, Wendt T, Sakaguchi T, Lalla E, Qu W, Lu Y, Lee L, Stern DM, Naka Y, Ramasamy R, Yan SD, Yan SF, D'Agati V, Schmidt AM. Blockade of receptor for advanced glycation endproducts: a new target fortherapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys. 2003 Nov 1;419(1):80-8. Review.

Ramasamy R. Aldose reductase: a novel target for cardioprotective interventions. Curr Drug Targets. 2003 Nov;4(8):625-32.

Ramasamy R, and P.J. Oates. Aldose reductase and vascular stress. In: S.P. Marso and D.M. Stern (Eds), Text Book of Diabetes Mellitus and Cardiovascular Disease, Lippincott Williams & Wilkins, Philadelphia, USA, 2003, p 55-74.

Collier TL, Hwang Y, Ramasamy R, Sciacca RR, Hickey KT, Simpson NR, Bergmann SR. Synthesis and initial evaluation of 17-(11)C-heptadecanoic acid for measurement of myocardial fatty acid metabolism. J Nucl Med. 2002 Dec;43(12):1707-14.

Hwang YC, Bakr S, Ramasamy R, Bergmann SR. Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium. Coron Artery Dis. 2002 Sep;13(6):313-8.

Pinsky DJ, Broekman MJ, Peschon JJ, Stocking KL, Fujita T, Ramasamy R, Connolly ES Jr, Huang J, Kiss S, Zhang Y, Choudhri TF, McTaggart RA, Liao H, Drosopoulos JH, Price VL, Marcus AJ, Maliszewski CR. Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest. 2002 Apr;109(8):1031-40.

Hwang YC, Sato S, Tsai JY, Yan S, Bakr S, Zhang H, Oates PJ, Ramasamy R. Aldose reductase activation is a key component of myocardial response to ischemia. FASEB J. 2002 Feb;16(2):243-5. Epub 2001 Dec 28.

Ramasamy R, YC Hwang, J Whang, SR Bergmann. Protection of ischemic hearts by high glucose is mediated by he glucose transporter, GLUT-4. American Journal of Physiology, 2001, 281:H290-H297.

Ramasamy R, YC Hwang, S Bakr, SR Bergmann. Protection of ischemic myocardium by inhibition of fatty acid uptake. Cardiovascular Research, 2001, 51:275-282.

Ramasamy R, JA Payne, J Whang, SR Bergmann, S Schaefer. Inhibition of electroneutral Na+-K+2CI- cotransporter protects diabetic myocardium from ischemic injury. American Journal of Physiology, 2001, 281:H515-522.

Ramasamy R, and SR Bergmann. Adjunctive protection of ischemic myocardium by modification of metabolism, pp. 253-268. In DeBono and BE Sobel (eds.), Challenges in Acute Coronary Syndromes, Blackwell Science, Oxford, UK 2001.

(Visit PubMed to view this faculty member's most recent articles.)

Abstracts

LK Lee, L. Bucciarelli, YC Hwang, S. Bakr, R. German, T. Wendt, W. Qu, Y Lu, A.M. Schmidt, and Ramasamy R. RAGE-dependent signaling in mononuclear phagocytes and endothelial cells generates oxidant stress and influences cardiac ischemic injury in diabetes. Circulation 2003, 108 (Suppl) IV- 204.

YC Hwang, S Shaw, M. Kaneko, H. Redd, MB Marrero, Ramasamy R. Aldose reductase and JAK-STAT signaling: A central mechanism mediating myocardial ischemic injury. Circulation 2003, 108 (Suppl) IV- 78.

J Guo, W Qu, Lu Y, Ramasamy R., Agati V, Schmidt AM, Wendt T. Blockade of RAGE suppresses adriamycin-induced oxidant stress in the kidney in BALB/c mice. J. Am. Soc. Nephrol. 2003, 14 : 554A.

Hwang YC, Bakr S, Ellory C, Oates PJ, Ramasamy, R. Sorbitol Dehydrogenase Inhibitors: A Novel Adjunctive Intervention For Protecting Ischemic Myocardium. Circulation 2002, 106 (suppl) II-194.

Ramasamy R., Hwang YC., Liu Y, Son NH., Szabolcs MJ., Cannon PJ. Cardioprotective effects of a selective inhibitor of NOS-2 dimerization during ischemia and reperfusion. Circulation 2002, 109 (suppl) II-212.

Presentations and Invited Lectures

Invited Symposium speaker, The BB RAT Turns Thirty: Lessons & Future Directions, December 3- 5, 2004, Ottawa, Canada, "Myocardial Metabolic and Ionic Fluxes In Diabetic BB Rat."

8th International Symposium on the Maillard Reaction, August 31, 2004. "RAGE-Dependent Signaling Generates Oxidant Stress and Influences Cardiac Ischemic Injury in Diabetes."

Life Sciences Symposium, Goa, India, April 30, 2004, "Translational Research- Bench to Bedside Study Design."

MV Diabetes Specialities Center and Madras Diabetes Research Foundation, Chennai, India, November 24, 2003. "Polyol Pathway, AGE-RAGE Interactions, and Myocardial Ischemic Injury in Diabetics."

8th European Association For Study of Diabetes & Juvenile Diabetes Research Foundation Oxford Workshop, Keble College, Oxford, UK, August 1-4, 2003, "Insights into pathogenic mechanisms underlying diabetic microvascular and cardiovascular complications: RAGE & ALDOSE REDUCTASE."

Indiana University School of Medicine, Indianapolis, March 27, 2003, Department of Radiology, Division of Imaging Sciences, "Metabolic and ionic mechanisms of myocardial ischemic injury."

Russ Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, "Aldose Reductase is a Key Component of Myocardial Ischemic Injury in Diabetics," April 2001.

University of Pennsylvania, Division of NMR Research, Aldose Reductase and Myocardial Ischemia, March 2000.

Session on Aldose Reductase and Cardiac Energy Metabolism, US-Japan Aldose Reductase workshop, Kona, Hawaii, January 2000.

Patents

Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MR spectroscopy.

Method for protecting heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia, or resulting from ischemia.

(Visit PubMed to view this faculty member's most recent articles.)