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Research Summary
My research focuses on clinical and cost outcomes of liver disease, in particular viral hepatitis and liver transplantation. The techniques used in my research include randomized clinical trials, multivariate linear and logistic regression, survival analysis, and decision tree and cost-effectiveness analyses.
Research Activities
1) Determinants of the outcome of orthotopic liver transplantation (OLT)
OLT is a highly successful therapy that has become a standard treatment for many forms of end stage liver disease. Since it is quite expensive, maximizing the benefit while decreasing the cost is of paramount importance. We are currently investigating the predictors of post-transplant outcomes in particular the impact of pre-transplant therapies like TIPS on cost and pre and post-transplant morbidity and mortality.
2) Quality of Life in Chronic Liver Disease
Chronic liver disease greatly impairs patients ability to function both physically and within societal and family roles. The impact of liver disease on quality of life has not been extensively investigated. We are utilizing liver disease-specific quality of life instruments and to analyze the impact of liver disease and its treatment on patients with liver disease, those undergoing treatment for Hepatitis C and potential donor and recipients of living donor liver transplants.
3) Artificial Liver Support
There is no currently viable support system for patients whose liver is failing analogous to dialysis for renal failure. Several devices have been proposed for this problem. These include those with living liver cells (bioartificial liver devices) and those without liver cells. We are actively involved in trials of both bioartificial as well as dialysis-based artificial liver support systems for acute and chronic liver failure.
4) Clinical Trials in Liver Disease and Transplantation
I am involved in many active clinical trials in Liver disease. In addition to studies of artificial liver support, we have several active drug protocols for Hepatitis B and C. We are also currently participating in several multi-center studies to investigate anti-viral prophylaxis strategies as well as various immunosuppressive agents following liver transplantation.
Positions & Appointments
| 2005-present |
Chief, Division of Hepatobiliary and Abdominal Transplant Surgery |
NewYork-Presbyterian Hospital/Columbia University Medical Center |
New York, NY |
| 2005-present |
Chief, Center for Liver Disease and Transplantation |
NewYork-Presbyterian Hospital/Columbia University Medical Center |
New York, NY |
| 2000-present |
Associate Professor of Medicine and Pediatrics (in Surgery) |
Columbia University College of Physicians & Surgeons |
New York, NY |
| 2000-present |
Attending Physician |
NewYork-Presbyterian Hospital/Columbia University Medical Center |
New York, NY |
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Education and Training
| 1996 |
MPH |
Graduate School of Public Health, University of California Berkeley, Berkeley, CA |
| 1992-1995 |
Fellow in Gastroenterology and Hepatology |
University of California San Francisco,
San Francisco, CA |
| 1991-1992 |
Senior Assistant Resident in Medicine |
Beth Israel Hospital, Boston, MA |
| 1990-1991 |
Junior Assistant Resident in Medicine |
Beth Israel Hospital, Boston, MA |
| 1989-1990 |
Intern in Medicine |
Beth Israel Hospital, Boston, MA |
| 1989 |
MD, alpha omega alpha |
New York University, New York, NY |
| 1985 |
BA, cum laude |
Harvard College, Cambridge, MA |
Honors and Awards
Fellow, American College of Gastroenterology, 2001
Fellow, American College of Physicians, 2000
Young Investigator Award, American Society of Transplant Physicians, 1996
Committees and Society Memberships
American Association for the Study of Liver Diseases, Clinical Research Committee
American College of Physicians
American College of Gastroenterology
American Gastroenterological Association
American Liver Foundation
American Society of Gastrointestinal Endoscopists
American Society of Transplant Physicians
American Society of Transplant Surgeons
American Society of Transplantation
International Liver Transplantation Society
Physician Volunteers for the Arts
United Network for Organ Sharing ad hoc Living Donor Committee, Chair Ethics Subcommittee
BOOKS
Brown Jr., Robert S., Guest Editor, Gastrointestinal Endoscopy – Clinics of North America, W.B. Saunders, Volume II, Number 1, January 2000.
CASE REPORTS
Yee HF Jr, Brown RS Jr, Ostroff JW. Fatal Clostridium difficile enteritis following total abdominal colectomy. J Clin Gastro 1995; 22: 45-7.
Brown RS Jr, Farraye F, Peppercorn MA, Glotzer DG, Antonioli D, Taylor G. Carcinoid tumor of the esophagus. J Clin Gastro 1994; 19: 338-9.
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