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Address:
PH
Room PH 14, 202
622 West 168th St
New York, NY   10032

Phone: 212-305-0914
Fax: 212-305-4343

Affiliations
-Columbia University College of Physicians & Surgeons
-Department of Medicine
-Division of Digestive & Liver Diseases


Robert S. Brown, Jr., MD, MPH

Research Summary
My research focuses on clinical and cost outcomes of liver disease, in particular viral hepatitis and liver transplantation. The techniques used in my research include randomized clinical trials, multivariate linear and logistic regression, survival analysis, and decision tree and cost-effectiveness analyses.

Research Activities
1) Determinants of the outcome of orthotopic liver transplantation (OLT)
OLT is a highly successful therapy that has become a standard treatment for many forms of end stage liver disease. Since it is quite expensive, maximizing the benefit while decreasing the cost is of paramount importance. We are currently investigating the predictors of post-transplant outcomes in particular the impact of pre-transplant therapies like TIPS on cost and pre and post-transplant morbidity and mortality.
2) Quality of Life in Chronic Liver Disease
Chronic liver disease greatly impairs patients ability to function both physically and within societal and family roles. The impact of liver disease on quality of life has not been extensively investigated. We are utilizing liver disease-specific quality of life instruments and to analyze the impact of liver disease and its treatment on patients with liver disease, those undergoing treatment for Hepatitis C and potential donor and recipients of living donor liver transplants.
3) Artificial Liver Support
There is no currently viable support system for patients whose liver is failing analogous to dialysis for renal failure. Several devices have been proposed for this problem. These include those with living liver cells (bioartificial liver devices) and those without liver cells. We are actively involved in trials of both bioartificial as well as dialysis-based artificial liver support systems for acute and chronic liver failure.
4) Clinical Trials in Liver Disease and Transplantation
I am involved in many active clinical trials in Liver disease. In addition to studies of artificial liver support, we have several active drug protocols for Hepatitis B and C. We are also currently participating in several multi-center studies to investigate anti-viral prophylaxis strategies as well as various immunosuppressive agents following liver transplantation.

Positions & Appointments
2005-present Chief, Division of Hepatobiliary and Abdominal Transplant Surgery NewYork-Presbyterian Hospital/Columbia University Medical Center New York, NY
2005-present Chief, Center for Liver Disease and Transplantation NewYork-Presbyterian Hospital/Columbia University Medical Center New York, NY
2000-present Associate Professor of Medicine and Pediatrics (in Surgery) Columbia University College of Physicians & Surgeons New York, NY
2000-present Attending Physician NewYork-Presbyterian Hospital/Columbia University Medical Center New York, NY


Education and Training
1996 MPH Graduate School of Public Health, University of California Berkeley, Berkeley, CA
1992-1995 Fellow in Gastroenterology and Hepatology University of California San Francisco,
San Francisco, CA
1991-1992 Senior Assistant Resident in Medicine Beth Israel Hospital, Boston, MA
1990-1991 Junior Assistant Resident in Medicine Beth Israel Hospital, Boston, MA
1989-1990 Intern in Medicine Beth Israel Hospital, Boston, MA
1989 MD, alpha omega alpha New York University, New York, NY
1985 BA, cum laude Harvard College, Cambridge, MA

Honors and Awards
Fellow, American College of Gastroenterology, 2001

Fellow, American College of Physicians, 2000

Young Investigator Award, American Society of Transplant Physicians, 1996

Committees and Society Memberships
American Association for the Study of Liver Diseases, Clinical Research Committee

American College of Physicians

American College of Gastroenterology

American Gastroenterological Association

American Liver Foundation

American Society of Gastrointestinal Endoscopists

American Society of Transplant Physicians

American Society of Transplant Surgeons

American Society of Transplantation

International Liver Transplantation Society

Physician Volunteers for the Arts

United Network for Organ Sharing ad hoc Living Donor Committee, Chair Ethics Subcommittee

BOOKS

Brown Jr., Robert S., Guest Editor, Gastrointestinal Endoscopy – Clinics of North America, W.B. Saunders, Volume II, Number 1, January 2000.

CASE REPORTS

Yee HF Jr, Brown RS Jr, Ostroff JW. Fatal Clostridium difficile enteritis following total abdominal colectomy. J Clin Gastro 1995; 22: 45-7.

Brown RS Jr, Farraye F, Peppercorn MA, Glotzer DG, Antonioli D, Taylor G. Carcinoid tumor of the esophagus. J Clin Gastro 1994; 19: 338-9.

 
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