Maria Karayiorgou, M.D.
Professor, Acting Chief
Acting Chief, Division of Psychiatric and Medical Genetics,
New York State Psychiatric Institute
Maria Karayiorgou, M.D., is a Professor of Psychiatry (in Genetics & Physiology) and Acting Chief of the Division of Medical Genetics in the Department of Psychiatry at Columbia University. Her intellectual interest in Psychiatry led her to medical school and clinical training in Psychiatry, as well as academic research in Psychiatric Genetics at the Massachusetts Institute of Technology, the Fred Hutchinson Center and the Rockefeller University. She came to Columbia University as a Professor in 2006.
Rare genetic variants in Schizophrenia etiology.
Medical School: National Capodistrian University of Athens, M.D., 1981-1987
Fellowship: Massachusetts Institute of Technology , 1988-1993
• Translational studies
NYS Psychiatric Institute
1051 Riverside Drive
New York, NY 10032
Dr. Karayiorgouï¿½s research program centers around the genetics of schizophrenia and aims to elucidate the genetic architecture of the disease, identify susceptibility genes for the disease, and use these findings to understand the underlying biology. To this end, she follows a number of complementary approaches designed to obtain convergent lines of evidence. Her approaches range from human genetic studies to animal model studies to clinical and translational neuroscience studies.
Landmark discoveries of Dr. Karayiorgouï¿½s research include the discovery of the importance of rare genetic variants in schizophrenia etiology, starting with an early publication that established a significant role in schizophrenia for a de novo CNV on 22q11.2 (Karayiorgou et al. PNAS 92, 7612-6, 1995) and culminating with recent whole exome sequencing studies (Xu et al. Nat Genet 44, 1365-9, 2012).
1. Xu B, Ionita-Laza I, Roos JL, Boone B, Woodrick S, Sun Y, Levy S, Gogos JA, Karayiorgou M.: De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia.
. Nature Genetics 2012;44: 1365-9
2. Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M. : Strong association of de novo copy number mutations with sporadic schizophrenia.. Nature Genetics 2008;40: 880-885
3. Xu B, Hsu PK, Stark KL, Karayiorgou M, Gogos JA.: Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.
. Cell 2013;152: 262-75
4. Gilman SR, Chang J, Xu B, Bawa TS, Gogos JA, Karayiorgou M, Vitkup D.
: Diverse types of genetic variation converge on functional gene networks involved in schizophrenia.. Nature Neuroscience 2012;15: 1723-8
5. Karayiorgou M, Flint J, Gogos JA, Malenka RC; Genetic and Neural Complexity in Psychiatry 2011 Working Group.
: The best of times, the worst of times for psychiatric disease.
. Nature Neuroscience 2012;15: 811-12