Maura Boldrini, M.D., Ph.D.
Research Scientist V, Molecular Imaging and Neuropathology Division,
New York State Psychiatric Institute
I am an M.D., Ph.D. with a Residency in Psychiatry and a Ph.D. in Neurobiology of Affective Disorders. I was further trained in a Janssen Postdoctoral Fellowship in Translational Neuroscience Research at Columbia University.
I worked as clinical psychiatrist in Hospital and University settings since 2003 and I currently hold positions as Assistant Professor of Clinical Neurobiology in Psychiatry at Columbia University and as Research Scientist at the New York State Psychiatric Institute.
I am a Kavli fellow since 2010 and I have been invited lecturer at different universities in the USA and abroad.
I am a member of the Society for Neuroscience, the Society of Biological Psychiatry, the American College of Neuropsychopharmacology and the International Academy of Suicide Research (IASR).
My research has been supported by: the American Foundation for Suicide Prevention (AFSP), NARSAD, the Italian National Ministry of Instruction, University and Research, the New York State Stem Cell Initiative (NYSTEM), NIMH and the Diane Goldberg Foundation.
Since 2002 have been teaching medical students and residents in psychiatry, and I have been mentoring high school, college and graduate students in my laboratory.
Topics of my publications have included: neuropsychological studies in patients with psychiatric disorders, psychopathology burden in patients with internal medicine diseases, genetic studies in eating disorders, studies on the serotonergic system in major depression and suicide and studies on brain neuroplasticity in mood disorders and in response to psychopharmacologic treatment.
Medical School: University of Pisa, M.D., 1987-1994
Doctoral Degree: University of Pisa, Ph.D., 1999-2003
Residency: University of Pisa, Psychiatrist, 1994-1998
Fellowship: Columbia University Medical Center, Neurobiology of suicide, 1999-2001
Post-Graduate: Vita-Salute San Raffaele University, Cognitive Neuropsychology, 1995-1996
Post-Graduate: Columbia University Medical Center, Adult human neurogenesis, 2006-2008
Board Certifications: Italian Board of Medicine and Surgery
Italian Board of Psychiatry
Italian Board of Psychotherapy
NYS Psychiatric Institute
Room 2917 Unit/Box:42
1051 Riverside Drive
New York, NY 10032
In my laboratory, current research focuses on studying adult neurogenesis and angiogenesis in the human brain. Adult neurogenesis is a mechanism of structural plasticity occurring in mammals including humans, which is necessary for learning and coping, shows adaptation to environment conditions and a significant response to medications. My research focuses on studying stem cells and their progeny in the human adult brain in the context of psychiatric, neurodevelopmental and neurodegenerative disorders. I am quantifying stem cells, cells at different stages of maturation on the neuronal and glial lineage and angiogenesis in the human autopsy brain. I am assessing the impact of psychiatric disorders, age, stress and psychopharmacological treatment on hippocampal neuroplasticity. I am studying trophic factors expression in correlation with levels of angiogenesis and neurogenesis in the human hippocampus. There are open postdoctoral positions in my lab.
1. Boldrini M, Santiago AN, Hen R, Dwork AJ, Rosoklija GB, Tamir H, Arango V Mann JJ. : Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression.. Neuropsychopharmacology 2013;May;38(6): 1068-77
1. Boldrini M, Mann JJ.: Depression and Suicide. In: Neurobiology of Brain Disorders. Edited by Michael J. Zigmond, Joseph T. Coyle and Lewis P. Rowland. , Elsevier, San Diego, CA, USA
1. Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V.: Hippocampal Angiogenesis and Progenitor Cell Proliferation are Increased with Antidepressant Use in Major Depression. . Biol Psychiatry 2012;Oct 1;72(7): 562-71
1. Boldrini M, Arango V.: Antidepressants, age and neuroprogenitors. Neuropsychopharmacology 2010;Jan;35(1): 351-2
1. Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. : Antidepressants increase neural progenitor cells in the human hippocampus. . Neuropsychopharmacology 2009;34(11): 2376-89