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Mark Hardy, MD

Positions and Appointments

1991-present  Auchincloss Professor of Surgery
Columbia University College of Physicians & Surgeons, New York, NY
2004-present  Director Emeritus and Founder, Renal and Islet Transplantation
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
1980-present  Attending Surgeon
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY

Clinical Specialties

Renal transplantation
General surgery with emphasis on parathyroid, angioaccess, breast, and soft tissue tumors
Islet transplantation and general surgery for diabetic patients

Research Interests

Transplant tolerance induction, pancreatic islet transplantation to cure diabetes, hepatocyte transplantation for liver disease, experimental clinical studies of immunosuppressive drugs.


Education and Training

1969-1971  Chief Resident and Vascular Fellow
Albert Einstein College of Medicine, New York, NY
1968-1969  Transplantation Fellow
Harvard Medical School, Boston, MA
1967-1968  Research Fellowship
Albert Einstein College of Medicine, New York, NY
1966-1967  Residency, General Surgery
Bronx Municipal Hospital Center, Bronx, NY
1963-1964  Residency, General Surgery
Strong Memorial Hospital - University of Rochester, Rochester, NY
1962-1963  Internship, Surgery/Medicine
Strong Memorial Hospital - University of Rochester, Rochester, NY
1962  MD
Albert Einstein College of Medicine, New York, NY
1958  BA
Columbia University, New York, NY

Board Certifications

Diplomate, American Board of Surgery, 1972
Diplomate, National Board of Medical Examiners, 1963

Professional Experience

1998-2008  Vice Chair, Medical Education and Employee Training
Columbia University College of Physicians and Surgeons, New York, NY
1998-2008  Director, Surgical Residency Program
Columbia University College of Physicians and Surgeons, New York, NY
1998-2004  Director, Renal & Islet Transplantation
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
1975-1987  Director of Transplantation-Dialysis
Columbia Presbyterian Medical Center, New York, NY
1975-1980  Associate Attending Surgeon
Columbia Presbyterian Medical Center, New York, NY
1975-1977  Visiting Attending and Consultant in Surgery
Hospital of the Albert Einstein College of Medicine, Municipal Hospital Center, Lincoln Hospital, Bronx, NY
1974-1975  Associate Attending in Surgery
Hospital of the Albert Einstein College of Medicine, Bronx Municipal Hospital Center, Lincoln Hospital, Bronx, NY
1972-1975  Director of Transplantation
Hospital of the Albert Einstein College of Medicine, Bronx Municipal Hospital Center, Lincoln Hospital, Bronx, NY
1971-1974  Assistant Attending in Surgery
Hospital of the Albert Einstein College of Medicine, Bronx Municipal Hospital Center, Lincoln Hospital, Bronx, NY

Professional Honors

Honorary Doctor of Philosophy, U. of Hallym, South Korea, 2004

AOA, Columbia University College of Physicians & Surgeons, 2003

Man of the Year – TRIO, 2000

Honoris Causa Doctoris, University of Warsaw, 2000

Honorary Member of Polish Surgical Society, 1999

NIH Academic Scholar in Surgery, 1968-1971

Professional Societies and Committees

American Association for the Advancement of Science
American Association for Cancer Education
American Association of Immunologists
American Association of Tissue Banks
American College of Surgeons
American Society of Artificial Internal Organs
American Society of Transplant Surgeons (Founding)
American Surgical Association
American Trauma Society (Founding)
Association for Academic Surgery
Biology Club III
Cell Transplant Society (Founding)
European Society for Surgical Research
Halsted Surgical Society
Institute of Immunology and Aging
International Association for Cardiac Biological Implants
International Cardiovascular Society
International Society for Heart Transplantation (Founding)
International Transplantation Society
Medical Society of the County of New York
New York Academy of Sciences
New York Cancer Society
New York Society of Nephrology
New York State Society of Surgeons
New York Surgical Society
New York Transplantation Society (Founding)
Pancreas & Islet Transplant Society (Founding)
Royal Society of Medicine
Societe Internationale de Chirugie
Society of Clinical Surgery
Society of Practitioners, Columbia Presbyterian Medical Center
Society of University Surgeons
The Melanoma Foundation
UNOS (Founding)

Selected Publications

Hardy MA, Witkowski P, Sondermeijer H, Harris P. The long road to pancreatic islet transplantation.World J Surg. 2010 Apr;34(4):625-7. PMID: 19830482

Guarrera JV, Arrington B, Birkhoff JD, Goldstein MJ,
Ratner LE, Kelly JA, Radhakrishnan J, Hardy MA. Nephrology image. Back-bench split of a deceased-donor horseshoe kidney for two transplant recipients. Kidney Int. 2009 Nov;76(9):1012. No abstract available. PMID: 19829314

CITR Research Group. 2007 update on allogeneic islet
transplantation from the Collaborative Islet Transplant Registry (CITR). Cell Transplant. 2009;18(7):753 67. Epub 2009 Sep 28.PMID: 19796497

Gomes LJ, Goldstein MJ, Hardy MA. The use of inferior epigastric artery in renal transplantation. Transplantation. 2009 Sep 15;88(5):748-9. No abstract available. PMID: 19741476

Halazun KJ, Hardy MA, Rana AA, Woodland DC 4th, Luyten EJ, Mahadev S, Witkowski P, Siegel AB, Brown RS Jr, Emond JC. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg. 2009 Jul;250(1):141-51.PMID: 19561458

Russo MJ, Rana A, Chen JM, Hong KN, Gelijns A, Moskowitz A,
Widmann WD, Ratner L, Naka Y, Hardy MA. Pretransplantation patient characteristics and survival following combined heart and kidney transplantation: an analysis of the United Network for Organ Sharing Database. Arch Surg. 2009 Mar;144(3):241-6.PMID: 19289663

Chan L, Greenstein S, Hardy MA, Hartmann E, Bunnapradist S, Cibrik D, Shaw LM, Munir L, Ulbricht B, Cooper M; CRADUS09 Study Group. Multicente, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness. Transplantation. 2008 Mar 27;85(6):821-6

Vlad G, D?Agati VD, Zhang QY, Liu Z, Ho EK, Mohanakumar T, Hardy MA, Cortesini R, Suciu-Foca N. Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplant in hu-NOD/SCID mice. Diabetes. 2008 Jul; 57(7):1878-86.Epub 2008 Apr 16.

Doft MA, Widmann WD, Hardy MA. Under a microscope: julius h. Jacobson, MD (1927- ). J Surg Educ. 2008 Jul-; 65(4)316-9.

Rana A, Robles S, Russo MJ, Halazun KJ, Woodland DC, Witkowski P, Ratner LE, Hardy MA. The combined organ effect: protection against rejection? Ann Surg. 2008 Nov;248(5):871-9.

Hogle NJ, Widmann WD, Ude AO, Hardy MA, Fowler DL. Does training novices to criteria and does rapid acquisition of skills on laparoscopic simulators have predictive validity or are we just playing video games? J Surg Educ. 2008 Nov-Dec; 65(6):431-5.

Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE. Role of vesicular monoamine transporter type2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol. 2008 Jul; 198(1):41-9.

Alejandro R, Barton FB, Hering BJ, Wease S; Collaborative Islet Transplant Registry Investigators. 2008 Update from the Collaborative Islet Transplant Registry. Transplantation. 2008 Dec 27;86(12):1783-8.PMID: 19104422

Liu J, Liu Z, Witkowski P, Vlad G, Manavalan JS, Scotto L, Kim-Schulze S, Cortesini R, Hardy MA, Suciu-Foca N.Rat CD8(+) FOXP3(+) T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol. 2004 Dec;13(4):239-47.

Goldstein MJ, Kim E, Widmann WD, Hardy MA. A 360 Evaluation of a Night-float System for General Surgery: A Response to Mandated Work-hours Reduction. Current Surgery. 61(5):445-451.

Hardy MA, Oluwole OO, Depaz HA, Gopinathan R, Ali AO, Garrovillo M and Oluwole SF. The Use of Allopeptides in Tolerance Induction In Rodents. Graft, 2003.

Oluwole SF, Oluwole OO, DePaz HA, Adeyeri AO, Witkowski P, Hardy MA, CD4+CD25+regulatory T cells mediate acquired transplant tolerance. Transplant Immunology. 11(3-4):287-93, 2003.

Liu EH, D’Alessandro DA, Hardy MA, Ethical issues in living renal donation. Transplantation Proceedings 35(3):1174-6, 2003.

Marvin MR, Droogan C, Sawinski D, Cohen DJ and Hardy MA: Administration of rabbit antithymocyte globulin (thymoglobulin) in ambulatory renal-transplant patients. Transplantation 75:488-9, 2003.

Jin M, Engelstad K, Oluwole SF and Hardy MA: Induction of stable chimerism and transplantation tolerance to rat islet and heart allografts by UV-B modulation of bone marrow cells. Transplantation 54:113-118, 1992.

Hardy MA, Suciu-Foca N, Reed E, Benvenisty AI, Smith C, Rose E, and Reemtsma K:Immunomodulation of kidney and heart transplants by anti-idiotypic antibodies. Annals of Surgery 214:522-530, 1991.

Hardy MA and Oluwole SF:Effect of ultraviolet radiation on immunogenicity of tissues and organ allografts. Transplant. Rev. 5:46-62, 1991.

Marin ML, Gordon RE, Hardy MA, Reemtsma K and Benvenisty AI:Immunomodulation of vascular endothelium:I.Ultrastructural changes following ultraviolet B irradiation of peripheral veins. J. surg. Res. 48:134-143, 1990.

Cohen DJ, Benvenisty AI and Hardy MA: OKT3 prophylaxis in cadaveric kidney transplant recipients with delayed graft function. Amer. J. Kid. Diseases 16:19-27, 1989.

Oluwole SF, Engelstad K and Hardy MA: Cellular immunity in allograft rejection:Role of lymphocyte subpopulations and T-cell subsets in rat cardiac allograft rejection. Cellular Immmunology 124:28-37, 1989.

Reed E, Hardy M, Benvenisty A, Lattes C, Brensilver J, McCabe R, Reemtsma K, King SW and Suciu-Foca N:Effect of antiidiotypic antibodies to HLA on graft survival in renal allograft recipients. N. Eng. J. Med. 316:1450-1455, 1987.

Reemtsma K, Hardy MA, Drusin RE, Smith CR and Rose EA:Cardiac transplantation:Changing patterns in evaluation and treatment. Ann. Of Surg. 202:418-424, 1985.

Hardy MA, Lau H, Weber C and Reemtsma K: Pancreatic islet transplantation:Induction of graft acceptance by ultraviolet irradiation of donor tisue. Annals of Surgery 200:441-450, 1984.

Lau H, Reemtsma K and Hardy MA: Pancreatic islet allograft prolongation with donor-specific blood transfusions treated with ultraviolet irradiation. Science 221:754-756, 1983.

Hardy MA: Beneficial effects of heterologous antilymphoid globulins in renal transplantation:One “believer’s view”. Am. J. Kidney Dis. 2:79-86, 1982.

Hardy MA, Nowygrod R, Elberg A and Appel G: Use of ATG in treatment of "steroid-resistant" rejection. Transplantation 29:161-164,1980.

Hardy MA, Fawwaz R, Oluwole S, Todd G, Nowygrod R and Reemtsma K: Selective lymphoid irradiation: An approach to transplantation. Surgery 86:194-202, 1979.

Hardy MA, Schneider K and Levitt SB: An improved technique for the construction of internal arteriovenous fistulae in uremic children. J. Ped. Surg. 9:465-466, 1974.


BOOKS

Loss, Grief & Care, M.A. Hardy, J. Kiernan, A.H. Kutscher, L. Cahill and A. Benvenisty (eds.), The Haworth Press, Inc., New York, 1991.

Xenograft 25, M.A. Hardy (ed.), Elsevier Science Publishers B.V., Amsteram 1989.

Transplantation of the Endocrine Pancreas in Diabetes Mellitus, R. van Schilfgaarde, M.A. Hardy (eds.), Elsevier Science Publishers B.V., Amsterdam 1988.

BOOK CHAPTERS

Greenfeld JI, and Hardy MA: Problems of reperfusion injury in organ transplants:The kidney. In:Reperfusion Injuries in Clinical Capillary Leak Syndrome, Zikria BA, Oz MO, and Carlson RW (eds) Armonk, N.Y.: Pupura Publishing Company, pp 293-312, 1994.

Oluwole SF and Hardy MA: Immunomodulation of UVB Irradiation: Induction of immunologic unresponsiveness to islet grafts in adult animals in “Pancreatic Islet Cell Transplantation”; ed. C. Ricordi; Published by RG Landes Co., Austin, Texas, 1992, pp 158-167.

Hardy MA and Chabot J:Alteration of pancreatic islets immunogenicity using ultraviolet irradiation. In: Transplantation of the Endocrine Pancreas in Diabetes Mellitus, R. van Schilfgaarde, M.A. Hardy (eds.), Elsevier Science Publishers B.V., Amsterdam, 1988, pp.301-307.

Benvenisty AI and Hardy MA: Selected complications on renal transplantation. In:Organ Transplantation and Replacement, J. Cerilli (ed.), 1988, pp. 462-470.

Fawwaz R, Oluwole S, Wang TS and Hardy MA: Immunosuppression nd induction of tolerance by radiolabeled porphyrin irradiation. In:Radionuclides in Therapy, R. Spencer, et al. (eds.), CRC, Boca Raton, FL, 1987, pp. 167-181.

Presentations

International Transplantation Society -- August, 2010, Vancouver, Canada

American Congress of Transplantation -- April, 2010, California

International Conference on Tolerance (Shustru Prize in Immunobiology) -- February, 2010, Amhedabad, India

European Society of Surgical Research (ESSR)--
May, 2008 Warsaw, Poland
May, 2009 Nantes, France
May, 2010 Geneva, Switzerland

American Congress of Transplanattion -- May, 2009, Boston, MA

American Congress of Transplanattion -- May, 2008, Wasnington, DC

International Missions
India -- Lady Widemore Mission Hospital, November, 2009, Manali, 4 weeks

Ethiopia -- Korean Mission Hospital, September 2010, Addis
Ababa, 4 weeks

(Visit PubMed to view this faculty member's most recent articles.)






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