Jonathan M. Chen, MD - Department of Surgery

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Jonathan M. Chen, MD

Positions and Appointments
2011-present		Adjunct Professor of Surgery
2011-present		Columbia University College of Physicians and Surgeons, New York, NY
2008-present		Surgical Director, Pediatric Heart Transplantation
2008-present		Morgan Stanley Children's Hospital of NewYork-Presbyterian, New York, NY
2004-present		Director, Pediatric Cardiac Surgery
2004-present		NewYork Weill Cornell Medical Center, New York, NY
2011-present		Professor Of Cardiothoracic Surgery In Pediatrics
2011-present		Weill Cornell Medical College, New York, NY
2011-present		Attending Surgeon
2011-present		NewYork-Presbyterian Hospital/Weill Cornell Medical College, New York, NY

Clinical Specialties

Aortic disease
Arterial insufficiency
Cardiac surgery
Congenital heart disease, adult
Congenital heart disease, pediatric
Heart failure

Research Interests

Congenital heart surgery
Alternative anticoagulants for heart surgery
Ventricular assist devices

Education and Training
January 2003-January 2004		Advanced Fellow in Congenital Cardiac Surgery
January 2003-January 2004		Morgan Stanley Children's Hospital of NewYork-Presbyterian, New York, NY
July 2002-December 2002		Advanced Fellow, Mechanical Cardiac Assistance
July 2002-December 2002		NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
July 2000-July 2002		Fellow, Cardiothoracic Surgery
July 2000-July 2002		NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
July 1999-June 2000		Chief Resident, General Surgery
July 1999-June 2000		NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
July 1997-June 1998		Research Fellow, Cardiac Surgery
July 1997-June 1998		NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
July 1994-June 1999		Intern and Resident, General Surgery
July 1994-June 1999		NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
1994		MD
1994		Columbia University College of Physicians & Surgeons, New York, NY
1990		BS
1990		Yale University, cum laude, New Haven, CT

Board Certifications

American Board of Surgery (2001)
American Board of Thoracic Surgery (2003, recertification 2012)
American Board of Congenital Heart Surgery (2011)

Professional Experience

2009-2011		Adjunct Associate Professor of Surgery
2009-2011		Columbia University College of Physicians and Surgeons, New York, NY
2011		David Wallace-Starr Foundation Associate Professor of Clinical Pediatric Cardiology
2011		Weill Medical College of Cornell University, New York, NY
2008-2011		Adjunct Associate Professor Of Surgery
2008-2011		Columbia University, New York, NY
2008-2011		Associate Professor Of Cardiothoracic Surgery In Pediatrics
2008-2011		Weill Medical College of Cornell University, New York, NY
2007-2011		Associate Professor Of Cardiothoracic Surgery
2007-2011		Weill Medical College of Cornell University, New York, NY
2004-2011		Associate Professor of Surgery
2004-2011		Weill Cornell Medical College, New York, NY
2005-2010		Clinical Assistant Professor Of Pediatrics
2005-2010		University of Medicine and Dentistry of New Jersey (Robert Wood Johnson Medical School), Newark, NJ
2004–2007		Assistant Professor Of Cardiothoracic Surgery
2004–2007		Weill Medical College of Cornell University, New York, NY
2004-2008		Adjunct Assistant Professor Of Surgery
2004-2008		Columbia University, New York, NY
2004		Assistant Professor of Surgery
2004		Columbia University, New York, NY

Professional Honors

2010
American Heart Association – New York
Young Hearts Award for Achievement in Cardiovascular Science and Medicine

New York's Top 100 Doctors
New York Magazine

2009
New York's Top 100 Doctors
New York Magazine

2008
New York's Top 100 Doctors
New York Magazine

2007
New York’s Top 100 Doctors
New York Magazine

2006
Crain's Business New York "40 Under 40"
Crain's Business Weekly

2002
Physician of the Year
Department of Nursing
NewYork-Presbyterian Hospital/Columbia University Medical Center

2000
Blakemore Research Award
Department of Surgery, Columbia University

Best Senior Resident Teaching Award
Department of Surgery, Columbia University

1999
Humanism and Excellence in Teaching Award
The Arnold P. Gold Foundation

1998
First Prize, Resident Research Competition
Department of Surgery, Columbia University

Trainee Award of Excellence
American Society for Artificial Internal Organs (ASAIO)

Professional Societies and Committees

New York Society for Thoracic Surgery
American Society of Transplantation
American Society of Transplant Surgeons
International Society For Heart and Lung Transplantation
Society of Alumni of the Presbyterian Hospital
Society of Thoracic Surgeons
American Heart Association
American College of Cardiology
American College of Surgeons
American Academy of Pediatrics
World Society for Pediatric and Congenital Heart Surgery
American Association for Thoracic Surgery
Association for Academic Surgery
Congenital Heart Surgeon’s Society
European Society for Cardio-Thoracic Surgery
Society of University Surgeons

Selected Publications

BOOK CHAPTERS

Pham MX, Chen JM, Berry GJ, Rose EA, Schroeder JS. Surgical treatment of heart failure, cardiac transplantation, and mechanical ventricular support. In: Hurst’s The Heart, Fuster V, O’Rourke RA, Walsh RA, Poole-Wilson PA (eds). 12th edition, McGraw Hill, 2008; 761-792.

Davies RR, Charette K, Chen JM, Mosca RS. Pediatric perfusion techniques for complex congenital surgery. In: On Bypass, Advanced Perfusion Techniques. Mongero L, Beck J (eds). Humana Press 2008; 29-58.

Davies RR, Chen JM, Mosca RS, Quaegebeur J. Cardiac surgery in the neonate with congenital heart disease. In: Hemodynamics and Cardiology, Kleinman CS, Seri I, Polin RA eds. Saunders Elsevier. 2008, pp 355-376.

Davies RR, Chen JM. Alternative procedures for hypoplastic left heart syndrome as a bridge to transplantation. In: Percutaneous Interventions for Congenital Heart Disease. Sievert H, Qureshi S, Wilson N, Hijazi Z (eds.). 2007; 539-548.

Hill JD, Farrar, Naka Y, Chen JM, Portner PM, Loisance D.. Positive displacement ventricular assist devices. In: Mechanical Circulatory Assistance (monograph). Kirklin J, Frazier O.H. (eds). Elsevier. 2006, pp. 53-77.

Chen JM, Schmidt AM, Rose EA. Advanced Cardiomyopathy and Surgery. In: Hemostasis and Thrombosis, 5th Edition, Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ (eds). Lippincott, Williams & Wilkins. 2006; 1529-1539.

Naka Y, Chen JM, Rose EA. Assisted circulation in the treatment of heart failure. In: Braunwald#146;s Heart Disease, 7th Edition, Zipes, Libby, Bonow and Braunwald (eds.). W.B. Saunders Press. 2003 pp. 625-639.

Chen JM, Morgan JA, Mosca RS. Techniques of transplantation for congenital heart disease. In: . Cardiac Transplantation: The Columbia University Medical Center/New York-Presbyterian Hospital Manual. Edwards NM, Chen JM, Mazzeo P (eds.) Humana Press. 2003, pp. 79-96.

Chen JM, Edwards NM. Donor selection and management of the high risk donor. In: Cardiac Transplantation: The Columbia University Medical Center/New York-Presbyterian Hospital Manual. Edwards NM, Chen JM, Mazzeo P (eds.) Humana Press. 2003, pp. 19-36.

Chen JM, Mosca RS. Surgical Management of Ventricular Septal Defects. In: Progress in Pediatric Cardiology . Gersony WM, (ed.), 2001; 14: 187-197.

Chen JM, Rose EA. The management of perioperative right-sided circulatory failure. In: Left Ventricular Assist Devices. Oz MC, Goldstein DJ, (Eds.) Future Publishing, 2000. p. 83-103.

Edwards, NM, Rajasinghe H, Chen JM, John R, Mancini DM. Cardiac transplantation in over 1000 patients: a single institution experience from Columbia University. In: Clinical Transplants 1999, Terasaki PI, Cecka (Eds). UCLA Tissue Typing Laboratory, Los Angeles 1999; 249-61.

Michler RE, Chen JM. Cutting-edge Heart Surgeries. In: Encyclopedia Britannica Medical and Health Annual 1998. E. Bernstein, (Ed.) Encyclopedia Britannica, Chicago, 1997. p.356-360.

Michler RE, Chen JM, Itescu S, Mancini DM, Oz MC, Smith CR, Rose EA. Cardiac transplantation at the Columbia-Presbyterian Medical Center: Twenty Year Experience. In: Clinical Transplants 1997, Terasaki PI, Cecka (Eds). UCLA Tissue Typing Laboratory, Los Angeles 1997.

Addonizio LJ, Kichuck M, Chen JM, Michler RE. Benefits and pitfalls of transplantation for patients with congenital heart disease. In: Pediatric Cardiopulmonary Transplantation, Franco KD (Ed.), Future Publishing Co, Armonk NY 1997 p 115-148.

Chen JM and Michler RE. The problem of pulmonary hypertension and the potential recipient. In: Transplantation and Replacement of Thoracic Organs., Cooper DKC (Ed.) 1996 p. 177-184

Michler RE and Chen JM. Cardiac Xenotransplantation: experimental advances, ethical issues and clinical potential. In: Handbook of Cardiac Transplantation, Miller L and Emery R (Eds). Hanley and Belfus, 1995 pp. 231-246

Levin HR, Chen JM, Dasse KA, Graham TR. End organ function during mechanical left ventricular assistance. In: Mechanical Circulatory Support, Lewis T (Ed.) Hodder and Stoughton, Kent. 1995, pp. 179-185.

Michler RE and Chen JM. Alternatives to Lung Allotransplantation: clinical potential and future prospects. In: Current Topics in General Thoracic Surgery-Lung Transplantation, Patterson A (Ed.). Elsevier Science B.V., Amsterdam. 1994, Vol 3: 565-579.

Michler RE, Chen JM, Mancini DM, Reemtsma K, Rose EA. Sixteen years of cardiac transplantation: the Columbia-Presbyterian Medical Center experience 1977 to 1993. In: Clinical Transplants 1993, Terasaki PI, Cecka (Eds). UCLA Tissue Typing Laboratory, Los Angeles 1994, Chapter 9, pp. 109-118.

Michler RE, Chen JM, and Rose EA. Cardiac xenotransplantation: insurmountable barrier or clinical reality? In: Advances in Cardiac Surgery, Volume 5, Karp RB, Wechsler AS (Eds). Mosby-Year Book, Inc., Chicago. 1993 pp. 232-244.

JOURNAL ARTICLES

Chiu P, Russo MJ, Davies RR, Addonizio LJ, Richmond ME, Chen JM. What is high risk? Redefining elevated pulmonary vascular resistance index in pediatric heart transplantation. J Heart Lung Transplant 2012; 31(1): 61-6.

Richmond ME, Charette K, Chen JM, Quaegebeur JM, Bacha E. The effect of cardiopulmonary bypass prime volume on the need for blood transfusion after pediatric cardiac surgery. Circulation 2012.

Haque R, Wojtasiewicz T, Gerrah R, Gilmore L, Saiki Y, Chen JM, Richmond M, Feldstein NA, Anderson RC. Management of intracranial hemorrhage in a child with a left ventricular assist device. Pediatr Transplant 2012.

Chen JM, Richmond ME, Charette K, Takayama H, Williams M, Gilmore L, Garcia A, Addonizio LJ. A decade of pediatric mechanical circulatory support before and after cardiac transplantation. J Thorac Cardiovasc Surg 2012; 143(2):344-51.

Takayama H, Chen JM, Jorde UP, Naka Y. Implantation technique of the CentriMag biventricular assist device allowing ambulatory rehabilitation. Interact Cardiovasc Thorac Surg 2011; 12(2):110-1.

Ofori-Amanfo G, Hsu D, Lamour JM, Mital S, O'Byrne ML, Smerling AJ, Chen JM, Mosca R, Addonizio LJ. Heart transplantation in children with markedly elevated pulmonary vascular resistance: Impact of right ventricular failure on outcome. J Heart Lung Transplant. 2011; Jan20 (epub ahead of print)

Davies RR, Russo MJ, Hong KN, Gelijns AC, Mital S, Mosca RS, Quaegebeur JM, Chen JM. Increased short-and long-term mortality at low volume pediatric heart transplant centers: should minimal standards be set? Ann Surg 2011;253:393-401.

Davies RR, Russo MJ, Yang J, Quaegebeur JM, Mosca RS and Chen JM. Listing and transplanting adults with congenital heart disease. Circulation 2011; 123:759-767.

Rafii DY, Davies RR, Carroll SJ, Quaegebeur JM, Chen JM. Age less than two years is not a risk factor for mortality after mitral valve replacement in children. Ann Thorac Surg 2011 (in press); 1228-34.

Auerbach SR, Richmond ME, Chen JM, Mosca RS, Quaegebeur JM, Addonizio LJ, Hsu DT, Lamour JM. Multiple risk factors before pediatric cardiac transplantation are associated with increased graft loss. Pediatric Cardiol 2011; Sept 4.

Gerrah R, Charette K, Chen JM. The first successful use of the Levitronix PediMAg ventricular support device as a biventricular bridge to transplant in an infant. J Thorac Cardiovasc Surg 2011; Apr 27.

Russo MJ, Hong KN, Davies RR, Chen JM, Mancini DM, Oz MC, Rose EA, Gelijns A, Naka Y. The effect of body mass index on survival following heart transplantation: do outcomes support consensus guidelines? Ann Surgery 2010; 251(1): 144-52.

Davies RR, Russo MJ, Morgan JA, Sorabella RA, Naka Y, Chen JM. Standard versus bicaval techniques for orthotopic heart transplantation: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg, 2010; 140(3): 700-8.

Russo MJ, Iribarne A, Hong KN, Ramlawi B, Chen JM, Takayama H, Mancini DM, Naka Y. Factors associated with primary graft failure after hear transplantation. Transplantation 2010; 90(4): 444-50.

Hirata Y, Quaegebeur JM, Mosca RS, Takayama H, Chen JM. Impact of aortic annular size on rate of reoperation for left ventricular outflow tract obstruction after repair of interrupted aortic arch and ventricular septal defect. Ann Thorac Surg 2010; 90(2): 588-92.

Russo MJ, Rana AA, Chen JM, Hong KN, Davies RR, Gelijns AC, Moskowitz AJ, Widmann WD, Ratner LE, Naka Y, Hardy MA. Pretransplant Patient Characteristics Determine Survival Following Combined Heart-Kidney Transplant: an analysis of the United Network for Organ Sharing Database. Arch Surg 2009; 144(3):241-6.

Prakash A, Khan MA, Hardy R, Torres AJ, Chen JM, Gersony WM. Evaluation of a new diagnostic algorithm before a fontan operation. J Thorac Cardiovasc Surg. 2009;138(4):917-23.

Davies RR, Sorabella RA, Yang JM, Mosca RS, Chen JM, Quaegebeur JM. Transplantation for the "failed" Fontan. Prog Ped Cardiol 2009; 26:21-29.

Silver ES, Liberman L, Chung WK, Spotnitz HM, Chen JM, Ackerman MJ, Moir C, Hordof AJ, Pass RH. Long QT syndrome due to a novel mutation in SCN5a; treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age. J Interv Card Electrophysiol 2009; 26(1): 41-5.

Vega JD, Moore J, Murray S, Chen J, Johnson MR, Dyke DB. Heart transplantation in the United States 1998-2007. Am J Transplant 2009 9(4Pt2):932-41.

Russo, MJ, Davies RR, Hong KN, Chen JM, Argenziano M, Moskowitz A, Ascheim DD, George I, Stewart AS, Williams M, Gelijns A, Naka Y. Matching high-risk recipients with marginal donors is a clinical effective strategy. Ann Thorac Surg 2009 87(4):1066-70.

Ceresnak SR, Liberman L, Chen JM, Hordof AJ, Lamberti JJ, Bonney WJ, Pass RH. An epicardial pacing safety net: an alternative technique for pacing in the young. Cardiol Young 2009; 19(3): 228-32.

Hirata Y, Chen JM, Quaegebeur JM, Mosca RS. The role of enucleation with or without septal myectomy for discrete subaortic stenosis. J Thorac Cardiovasc Surg 2009; 137:1168-72.

Auerbach SR, Manlhiot C, Reddy S, Kinnear C, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation. J Am Coll Cardiol 2009; 53:1909-17.

Russo MJ, Hong KH, Davies RR, Chen JM, Sorabella RA, Ascheim DD, Willliams MR, Gelijns AC, Stewart AS, Argenziano M, Naka Y. Post-transplant survival is not diminished in heart transplant recipients bridged with implantable left ventricular assist devices. J Thorac Cardiovasc Surg 2009; 138(6): 1425-32.

Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS, Quaegebeur JM, Addonizio LJ, Hsu DT, Chen JM. Twenty-year experience with heart transplantation for infants and children with restrictive cardiomyopathy: 1986-2006. Am J Transplant 2008; 8(1):201-7

Davies RR, Russo MJ, Mital SR, Martens TM, Sorabella RS, Hong KN, Gelijns AC, Moskowitz AJ, Quaegebeur JM, Mosca RS, Chen JM. Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg 2008 Jan;135(1):147-55

Herrold K, Herrold EM, Bograd AJ, Richmond M, Flynn PA, Cooper RS, Chen JM. The malignant course of acute rheumatic fever in the modern era: implications for early surgical intervention for bivalvular insufficiency with impaired ventricular function. Ped Cardiol 2008 Mar-Apr;29(2):297-300.

Hirata Y, Chen JM, Quaegebeur JM, Mosca RS. Should we address the neo-pulmonic valve? Significance of right-sided obstruction after surgery for transposition of the great arteries and coarctation. Ann Thorac Surg 2008; 86(4): 1293-8.

Russo MJ, Rana AA, Chen JM, Hong KN, Davies RR, Gelijns AC, Moskowitz AJ, Widmann WD, Ratner LE, Naka Y, Hardy MA. Pretransplant Patient Characteristics Determine Survival Following Combined Heart-Kidney Transplant: an analysis of the United Network for Organ Sharing Database. Arch Surg 2008; 144(3):241-6.

Chen JM. “Take another little piece of my heart now": should endomyocardial biopsy remain the gold standard? Transplantation. 2008 85(7):934.

Turbendian HK, Carroll SJ, Chen JM. Left ventricular diverticulum repair in a case of incomplete Cantrell’s syndrome. Cardiol Young 2008 Jun 30:1-2.

Hirata Y, Charette K, Mosca RS, Quaegebeur JM, Chen JM. Pediatric application of the Thoratec CentriMag BiVAD as a bridge to heart transplantation. J Thorac Cardiovasc Surg 2008 136(5): 1386-7.

Kaufman BD, Desai M, Reddy S, Osorio JC, Chen JM, Mosca RS, Ferrante AW, Mital S. Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Cardiac Fail 2008; 14(9): 760-7.

Davies RR, Russo MJ, Hong K, O’Byrne ML, Cork DP, Moskowitz AJ, Gelijns AC, Mital S, Mosca RS, Chen JM. The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: an analysis of the United Network for Organ Sharing Database. J Thorac Cardiovasc Surg 2008; 421-7.

Gray RE, Altmann K, Mosca RS, Williams I, Prakash A, Quagebeur JM, Chen JM. Persistent antegrade pulmonary blood flow post-Glenn does not alter early post-Fontan outcomes in single ventricle patients. Ann Thorac Surg 2007; 84:888-93.

Hirata Y, Chen JM, Mosca RS, Hellenbrand WE, Quaegebeur JM. Lessons learned in the management of pulmonary atresia/intact ventricular septum: effect of catheter-based interventions. Ann Thorac Surg 2007; 84(2):574-9.

Charette K, Hirata Y, Bograd A, Chen J, Quaegebeur J, Mosca R. 180ml and less: cardiopulmonary bypass techniques to minimize hemodilution for neonates and small infants. Perfusion 2007 Sep;22(5):327-31.

Ceresnak S, Gray RG, Altmann K, Chen JM, Glickstein JS, Hellenbrand WE. Coronary artery fistulas: a review of the literature and presentation of two cases of coronary fistulas with drainage into the left atrium. Congenit Heart Dis 2007; 2:208-213.

Carroll SJ, Ferris A, Chen J, Liberman L. Efficacy of Prostaglandin E1 in relieving obstruction in coarctation of a persistent fifth aortic arch without opening the ductus arteriosus. Pediatr Cardiol 2006; 27:766-768.

Richmond ME, Addonizio LJ, Hsu DT, Mital SR, Mosca RS, Quaegebeur JM, Chen J, Lamour, JM. Cardiac retransplantation in high risk pediatric patients. Pediatr Transplantation 2007: 11: 615-623.

Russo MJ, Chen JM, Sorabella RA, Martens TM, Garrido M, Mosca RS, Mital SR, Ascheim DD, Argenziano M, Stewart AS, Oz MC, Naka Y. Effect of ischemic time on survival following heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing Database. J Thorac Cardiovasc Surg, 2007; 133:554-9.

Russo MJ Chen JM, Hong KN, Stewart AS, Ascheim DD, Argenziano M, Mancini DM, Oz MC, Naka Y, Columbia University Heart Transplant Outcomes Research Group. Survival after heart transplantation is not diminished among recipients with uncomplicated diabetes mellitus: an analysis of the United Network of Organ Sharing database. Circulation 2006; 114(21):2280-7.

Llima B, Kherani AR, Hata JA, Cheema FH, Casher J, Oz MC, Rao V, Fal JM, Chen JM, Morgan JA, Vigilance DW, Garrido MJ, Milano CA, Naka Y. Does the Columbia-Presbyterian pre-LVAD screening score predict transplant success? Heart Surg Forum 2006;9:E783-5.

Reddy S, Osorio JC, Duque AM, Kaufman BD, Phillips AB, Chen JM, Quaegebeur JM, Mosca RS, Mital SR. Failure of right ventricular adaptation in children with Tetralogy of Fallot. Circulation 2006; 114: 37-42.

Chen, JM, Glickstein JS, Margossian R, Phillips AB, Mercando ML, Hellenbrand WE, Mosca RS, Quaegebeur JM. Superior Outcomes Using a Valveless Technique for Repair of Infants and Neonates with Tetralogy of Fallot /Absent Pulmonary Valve Syndrome. J. Thorac Cardiovasc Surg 2006 2006;132:1099-104.

Russo, MJ, Davies RR, Sorabella R, Martens TM, George I, Cheema FH, Mital SR, Mosca RS, Chen JM. Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network for Organ Sharing Database. J Thorac Cardiovasc Surg, 2006;132:1208-12.

Chen JM, Naka Y, Rose EA. The future of left ventricular assist device (LVAD) therapy in adults. Nature Clin Pract Cardiovasc Med, 2006; 3(2):346-7.

Russo, MJ, Davies RR, Sorabella R, Martens TM, George I, Cheema FH, Mital SR, Mosca RS, Chen JM. Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network for Organ Sharing Database. J Thorac Cardiovasc Surg, 2006;132:1208-12.

Chen, JM, Glickstein JS, Margossian R, Phillips AB, Mercando ML, Hellenbrand WE, Mosca RS, Quaegebeur JM. Superior Outcomes Using a Valveless Technique for Repair of Infants and Neonates with Tetralogy of Fallot /Absent Pulmonary Valve Syndrome. J. Thorac Cardiovasc Surg 2006 2006;132:1099-104.

Reddy S, Osorio JC, Duque AM, Kaufman BD, Phillips AB, Chen JM, Quaegebeur JM, Mosca RS, Mital SR. Failure of right ventricular adaptation in children with Tetralogy of Fallot. Circulation 2006; 114: 37-42.

Russo MJ, Chen JM, Sorabella RA, Martens TM, Garrido M, Mosca RS, Mital SR, Ascheim DD, Argenziano M, Stewart AS, Oz MC, Naka Y. Effect of ischemic time on survival following heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing Database. J Thorac Cardiovasc Surg, 2006 (in press).

Russo MJ, Mancini DM, Sorabella R, Martens TM, George I, Cheema FH, Chen JM, Naka Y. Survival following heart transplantation is not diminished among recipients with uncomplicated diabetes mellitus: an analysis of the United Network for Organ Sharing Database. Circulation, 2006 (in press).

Chen JM, Glickstein JS, Davies RR, Mercando ML, Mosca RS, Quaegebeur JM. Evolving techniques in the repair of truncus arteriosus 1990-2003. J Thorac Cardiovasc Surg 2005; 129 (3) 559-68).

Chen JM, Glickstein JS, Davies RR, Mercando ML, Mosca RS, Quaegebeur JM. Evolving techniques in the repair of truncus arteriosus 1990-2003. J Thorac Cardiovasc Surg 2005; 129 (3) 559-68).

Xydas S, Yang JK, Burke EM, Chen JM, Addonizio LJ, Mital SR, Itescu S, Hsu DT, Lamour JM. The utility of post-transplant anti-HLA antibody measurements in pediatric cardiac transplant recipients. J Heart Lung Transplant, 2005;24(9):1289-96.

Pinney SP, Cheema FH, Hammond K, Chen JM, Edwards NM, Mancini DM. Acceptable recipient outcomes with the use of hearts from donors with Hepatitis B Core antibodies. J Heart Lung Transplant, 2005; 24:34-7..

Chen JM, Hammond KM, Kherani AR, Fal JM, Mazzeo PA, Pinney SP, Mancini DM, Edwards NM. Is The Alternate Waiting List Too High Risk? The Columbia-Presbyterian Experience. Ann Thorac Surg, 2005; 80:224-8.

Kherani AR, Cheema FH, Casher J, Fal JM, Mutrie CJ, Chen JM, Morgan JA, Vigilance DW, Garrido, MJ, Smith CR, Oz MC. The edge-to-edge mitral valve repair: the Columbia-Presbyterian experience. AnnThorac Surg 2004;78:73-6.

Morgan JA, Oz MC, Rose Ea, Weinberg AD, Chen JM, Flannery MR, Idrissi Ka, Mazzeo PA, Naka Y. Lessons learned from 236 long-term heartmate left ventricular assist devices: a 12-year review of the Columbia-Presbyterian experience J Thorac Cardiovasc Surg 2004;127(5):1309-16.

Chen JM, Mosca RS, Altmann K, Printz BF, Targoff K, Mazzeo PA, Quaegebeur JM. Early and Medium Term Results With Repair of Ebstein's Anomaly. J Thorac Cardiovasc Surg 2004; 127(4):990-999.

Chen JM, Davies RR, Mital SR, Mercando ML, Addonizio LJ, Pinney SP, Hsu DT, Lamour JM, Mosca RS and Quaegebeur JM. Trends and outcomes in transplantation for complex congenital heart disease 1984-2003. Ann Thorac Surg 2004; 78(4) :1352-1361.

Chen JM, Naka Y, Rose EA. New strategies to expand the donor pool: are they misguided? Nature Clin Pract Cardiovasc Med, 2004; 1(1): 2-3.

Lamour JM, Hsu DT, Quaegebeur JM, Pinney SP, Mital SR, Mosca RS, Chen JM, Addonizio LJ. Heart transplantation to a physiologic single lung in patients with congenital heart disease. J Heart Lung Transplant 2004; 23: 948-53.

Chen, JM, Naka Y, Rose EA. Practice Point Commentary: Optimal timing of cardiac transplantation after ventricular assist device implantation. Nature Clin Pract Cardiovasc Med, 2004; 1(2): 82-83.

Chen JM, Rajasinghe HR, Sinha P, Suratwala SJ, McCue JD, Hauff HM, John R, Edwards NM. Do donor characteristics really matter? Analysis of consecutive heart donors 1995-1999. J Heart Lung Transplant 2002 May;21(5):608-10.

John R, Rajasinghe H, Chen JM, Sinha P, Mancini DM, Rose EA, Edwards NM. Long term outcomes following cardiac transplantation: an experience based on different eras of immunosuppression. Ann Thorac Surg 2001; 72(2): 440-9.

Michler RE and Chen JM. Cardiac Xenotransplantation: ethics and potential application. J. Cardiac Surg 2001; 16: 421-428.

Gold J, Cullinane S, Chen J, Seo S, Oz MC, Oliver JA, Landry DW. Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. Am J Cardiol 2000; 85(4): 506-8.

Gold JA, Culllinane S, Chen J, Oz MC, Oliver JA, Landry DW. Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. Crit Care Med 2000; 28(1): 249-52.

Sinha P, Chen JM, Rajasinghe HR, Oz MC, Edwards NM. Infections during left-ventricular assist device support do not affect post-transplant outcomes. Circulation 2000; 102(19Suppl3):III194-9.

John R, Chen JM, Rajasinghe HR, Mancini DM, Oz MC, Rose EA, Smith CR, Edwards NM. Impact of current management practices on early and late mortality in over 500 consecutive cardiac transplant recipients. Ann Surg 2000; 232(3): 302-11.

Argenziano M, Chen JM, Cullinane S, Choudhri AF, Rose EA, Smith CR, Edwards NM, Landry DW, Oz MC. Arginine vasopressin in the management of vasodilatory hypotension after cardiac transplantation. J Heart Lung Transplant 1999; 18:814-817.

Beck JR, Mongero LB, Kroslowitz RM, Choudhri AF, Chen JM, DeRose JJ, Argenziano M, Smerling AJ, Oz MC. Inhaled nitric oxide improves hemodynmaics in patients with acute pulmonary hypertension after high-risk cardiac surgery. Perfusion 1999; 14:37-42.

Spanier TB, Chen JM, Mancini DM, Smith CR, Edwards NM. Cardiac transplantation in a patient with protein S deficiency. Ann Thorac Surg 1999;68(3):1078-80.

Cantu E, Maruyama S, DeMartino C, Wang CY, Chen JM, Al-Mohanna FAA, Nakeeb SM, Agati V, Pernis B, Galili U, Godman G, Stern DM, Andres G. Interaction of baboon anti-a-galactosyl antibody with pig tissues. Am J Pathol 1999;155(5):1635-49.

Madigan JD, Choudhri AF, Chen JM, Spotnitz HM, Oz MC, Edwards NM. Surgical management of the patient with an implanted cardiac device: implications of electromagnetic interference. Ann Surg 1999;230(5):639-47.

Helman DN, Morales DLS, Edwards NM, Mancini DM, Chen JM, Rose EA, Oz MC. Left ventricular assist device bridge to transplant network improves survival after failed cardiotomy. Ann Thorac Surg 1999; 68 (4): 1187-94.

John R, Chen JM, Weinberg AD, Oz MC, Mancini DM, Itescu S, Galantowicz ME, Smith CR, Rose EA, Edwards NM. Long term survival after cardiac retransplantation: a 20 year single center experience. J Thorac Cardiovasc Surg 1999; 117(3): 543-55.

Spanier TB, Chen JM, Oz MC, Stern DM, Rose EA, Schmidt AM. Time dependent cellular population of textured-surfaced left ventricular assist devices contributes to the development of a biphasic systemic procoagulant response. J Thorac Cardiovasc Surg 1999; 118 (3):404-13.

Chen JM, Cullinane S, Spanier TB, Artrip JH, John R, Edwards NM, Oz MC, Landry DW. Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation 1999; 100(19 Suppl):II244-6.

Morales DLS, Madigan J, Cullinane S, Chen JM, Heath M, Oz MC, Oliver JA, Landry DW. Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock. Circulation 1999; 20;100(3):226-9.

Rosensweig EB, Starc TJ, Chen JM, Cullinane S, Timchak DM, Gersony WM, Landry DW, Galatonwicz, ME. Intravenous arginine-vasopressin in children with vasodilatory shock after cardiac surgery. Circulation 1999; 100 (19 Suppl): II182-6.

Chen JM, De Rose JJ, Slater JP, Spanier TB, Dewey TM, Cullinane S, Catanese KA, Flannery, MA, Oz MC. Improved survival rates support left ventricular assist device implantation early after myocardial infarction. J Am Coll Cardiol. 1999;33(7):1903-8.

Sollano JA, Gelijns AC, Moskowitz AJ, Heijan DF, Cullinane S, Saha T, Chen JM, Roohan PJ, Reemtsma K, Shields EP, Volume-outcomes relationships in cardiovascular surgery: New York State 1990-1995. J Thorac Cardiovasc Surg 1999; 117:419-30.

Chen JM, Spanier TB, Gonzalez JJ, Marelli D, Catanese KA, Flannery MA, Cullinane S, Tector KA, Oz MC. Improved survival in patients with acute myocarditis using external pulsatile mechanical ventricular assistance. J Heart Lung Transplant 1999; 18(4):351-7

Dewey TM, Chen JM, Spanier TB, Oz, MC. Alternative technique of right sided outflow cannula insertion for right ventricular support. Ann Thorac Surg 1998; 66: 1829-30.

Argenziano M, Chen JM, Choudhri AF, Landry DW, Weinberg AD, Smith CR, Rose EA, Oz MC. Management of vasodilatory shock after high-risk cardiac surgery: identification of predisposing factors and use of a novel pressor agent. J. Thorac Cardiovasc Surg 1998; 116: 973-80.

Spanier TB, Chen JM, Oz MC, Edwards NM, Kisiel W, Stern DM, Rose EA, Schmidt AM. Selective anticoagulation with active site blocked factor IXa (IXai) implicates distinct roles for intrinsic and extrinsic pathways in cardiopulmonary bypass. J Thorac Cardiovasc Surg 1998; 116(5): 860-9.

Chadburn A., Chen JM, Hsu DT, Frizzera G, Cessarman E, Garrett TJ, Mears JG, Zangwill S, Addonizio LJ, Michler RE, Knowles DM. The morphologic and molecular genetic categories of post-transplantation lymphoproliferative disorders (PT-LPDs) are clinical relevant. Cancer 1998; 82(10): 1978-87.

Raman KG, Radhadrishnan J, Valeri A, Chen JM, Benvenisty AI, Hardy MA. Toxicity of anticardiolipin antibody in hemodialysis vascular access. Surg Forum 1997; 48:374-6.

Slater JP, Lipsitz EC, Chen JM, Levin HR, Oz MC, Goldstein DJ, Ashton RC, Burkhoff D. Systolic ventricular interaction in normal and diseased explanted human hearts. J Thorac Cardiovasc Surg 1997; 113: 1091-9.

Chen JM, Levin HR, Michler RE, Prusmack CJ, Rose EA, Aaronson KD. Reevaluating the significant of pulmonary hypertension prior to cardiac transplantation: determination of optimal thresholds and quantification of the effect of reversibility on perioperative mortality. J. Thorac Cardiovasc Surg 1997; 114(4): 627-634.

Chen JM, Weinberg AD, Rose EA, Mancini DM, Reemtsma K, Michler RE. Multivariable analysis of factors affecting waiting time to heart transplantation. Ann Thorac Surg 1996; 61: 570-75.

Chen JM, Levin HR, Rose EA, Addonizio LJ, Landry DW, Sistino JJ, Michler RE, Oz MC. Experience with right ventricular assist devices for perioperative right sided circulatory failure. Ann Thorac Surg, 1996; 61:305-310.

Kim L, Chen JM, Nowygrod R, Benvenisty AI. Management of middle aortic syndrome in children. J Vasc Surg 1996; 25(4): 778-783.

Xu H, Oluwole SF, Edwards NM, Chen JM, Naka Y, Kim E, Michler RE. In vitro evaluation of newborn human immunity against the pig. J Thorac Cardiovasc Surg 1996; 111: 920-9.

Xu H, Edwards NM, Chen JM, Kwiatkowski P, Rosenberg SE, Michler RE. Newborn baboon serum lacks natural anti-pig xenoantibody. Transplantation 1995; 59(8): 1189-1194.

Xu H, Edwards NM, Chen JM, Dong X, Michler RE. Natrual anti-pig xenoantibody is absent in newborn human serum. J Heart Lung Transplant 1995; 749-54.

Xu H, Edwards NM, Chen JM, Dong X, Michler RE. Age-related development of human anti-pig xenoantibodies. J Thorac Cardiovasc Surg 1995; 110: 1023-29.

Levin HR, Burkhoff D, Oz MC, Chen JM, Rose EA, Packer M. Reveral of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation 1995; 91:2717-2720.

Goldstein DJ, Seldomridge JA, Chen JM, Catanese KA, DeRosa CM, Weinberg AD, Smith CR, Rose EA Levin HR and Oz MC. Use of aprotinin in LVAD recipients reduces blood loss, blood product requirement and perioperative mortality. Ann Thorac Surg 1995; 59: 1063-8.

Slater JP, Lipsitz EC, Chen JM, Levin HR, Oz MC, Nowygrod R, Burkhoff D. Use of explanted human hearts as a model for studying cardiac physiology. J. Thorac Cardiovasc Surg 1995; 110: 239-47

Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen JM, Garrett TJ, Mears G, Michler RE. Molecular genetic analysis demonstrates three distinct categories of post-transplantation lymphoproliferative disorders and is useful in predicting their behavior. Blood 1995; 85(2): 552-565.

Chen JM, Levin HR, Catanese KA, Sistino JJ, Landry DW, Rose EA, Oz MC. Use of a pulsatile right ventricular assist device and continuous arteriovenous hemodialysis in a 57 year old man with a pulsatile left ventricular assist device. J Heart Lung Transplant 1994; 14 (1 Pt. 1): 186-191.

Xu H, Kwiatkowski P, Chen JM, Kaplon RJ, Edwards NM, Dong X, Berger C, Michler RE. Abrogation of baboon natural xenoantibody to pig splenocytes by DL-Penicillamine. Transplantation 1994; 58(12):1299-1303.

Michler RE and Chen JM. Cardiac xenotransplantation: a therapy whose time has come. Xeno, 1994; 2(4): 55-56.

Michler RE, Chen JM, Quaegebeur JM. Novel technique for extending the use of allografts in cardiac operations. Ann Thorac Surg, 1994; 57:83-7. (Reply Ann Thorac Surg 1994; 58:915)

Levin HR, Chen JM, Oz, MC, Catanese KA, Krum H, Goldsmith RL, Packer M, Rose EA. Potential of left ventricular assist devices as outpatient therapy while awaiting transplantation. Ann Thorac Surg, 1994; 58: 1515-1520.

Chen JM, Barr ML, Chadburn A, Frizzera G, Schenckel FA, Sciacca RR, Reison DS, Addonizio LJ, Rose EA, Knowles DM and Michler, RE. Management of lymphoproliferative disorders after cardiac transplantation. Ann Thorac Surg 1993; 56:527-538.

Michler RE, McLaughlin MJ, Chen JM, Sciacca RR, Geimer R, Schenkel F, Smith CR, Rose EA, Barr ML. Clinical Experience With Cardiac Retransplantation. J. Thorac Cardiovasc Surg 1993; 106(4):622-631.

Garrett TP, Chadburn A, Barr ML, Drusin RE, Chen JM, Schulman LL, Smith CR, Reison DS, Rose EA, Knowles DM, and Micher RE. Post-transplantation lymphoproliferative disorders treated with cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy. Cancer, 1993; 72:2782-5.

Xu H, Edwards NM, Kaplon RJ, Dong X, Chen JM, Kwiakowski P, Michler RE. Identification and functional analysis of human preformed anti-pig xenoantibodies. Transplant Proc 1993; 26(3): 1365-1368

Chen JM and Michler RE. Heart Xenotransplantation: lessons learned and future prospects. J. Heart Lung Transplant. 1993; 12(5): 869-875.

MONOGRAPHS--EDITOR

Cardiac Transplantation: The Columbia University Medical Center/New York-Presbyterian Hospital Manual. Edwards NM, Chen JM (eds.) Humana Press. 2003

SELECTED PRESENTATIONS

“Transplantation for Complex Congenital Heart Disease in the Adult Patient.” The Society of Thoracic Surgeons. 48th Annual Meeting. Fort Lauderdale, FL. Janaury 30, 2012.

“The Before, The During and the After of Pediatric Heart Surgery” – Moderator, American Heart Association Scientific Sessions 2011. Orlando, FL. November 15, 2011.

“Neonatal heart transplantation: obstacles and future horizons”. Grand Rounds. Nemours Heart Center, Alfred I. duPont Hospital for Children, Wilmington, DE. October 31, 2011.

“Pediatric Ventricular Assist Devices” Controversies in Pediatric Cardiology” New York, October 29, 2011.

“Indications and Strategies of Neonatal Heart Transplantation” (invited) The Society of Thoracic Surgeons. 47th Annual Meeting. San Diego, CA. Janaury 29, 2011.

“Surgery for Congenital Heart Disease: Current Controversies” – Moderator. American Heart Association Scientific Sessions 2010. Chicago, IL. November 15, 2010.

“Surgical Alternatives for the Failing Fontan”. (invited) European Association for Cardiothoracic Surgery. 24th Annual Meeting . Geneva, Switzerland. September 12, 2010.

“How to Manage an Infant with TGA/VSD/PS” – Moderator. American Heart Association Scientific Sessions 2009. Orlando, Fl. November 16, 2009.

“Heart transplantation for adult congenital heart disease”. 15th Annual Irena Jakubcova Lecture - Open Heart Institute Symposium on Grown Up Congenital Heart Disease, Bratislava, Slovakia. November 5, 2009.

“Surgical Management of Adult Single Ventricle Patients”. 15th Annual Irena Jakubcova Lecture - Open Heart Institute Symposium on Grown Up Congenital Heart Disease, Bratislava, Slovakia. November 5, 2009.

“Management of the Adult With Tetralogy of Fallot”. 15th Annual Irena Jakubcova Lecture - Open Heart Institute Symposium on Grown Up Congenital Heart Disease, Bratislava, Slovakia. November 5, 2009.

“Lessons Learned in the Surgical Management of Pediatric Patients Undergoing Heart Transplanation”. Japanese Society of Heart Transplantation. 28th Annual Meeting, Fukuoka, Japan. October 31, 2009.

“Adult Congenital Heart Transplantation: Short and Long Term Outcomes and Future Directions” (invited) The International Society for Heart and Lung Transplantation, 29th Annual Meeting, Paris, France, April 22, 2009.

“Transplantation for the Failing Fontan”. (invited) The American College of Cardiology, 58th Annual Scientific Sessions 2009, Orlando, FL. March 30, 2009.

“Anticoagulation management in the failing heart and device supported hearts.” (invited) The American Heart Associations, Scientific Sessions 2008, New Orleans, LA. November 11, 2008.

“Status of mechanical circulatory support in pediatric heart failure”. (invited) The American Heart Association. Scientific Sessions 2005. Dallas, TX. November 13, 2005.

“Novel anticoagulation for cardiopulmonary bypass.” (invited) The American College of Surgeons, 91st Clinical Congress, San Francisco, CA. October 18, 2005.

"Improved survival with repair of tetralogy of fallot/absent pulmonary valve syndrome." American Academy of Pediatrics, 75th Annual Meeting, Washington, D.C., October 8, 2005.

"Evolving techniques in the repair of truncus arteriosus 1990-2003." American Association for Thoracic Surgery. 84th Annual Meeting. Toronto, Canada. April 26, 2004.

"Trends and Outcomes in Transplantation for Complex Congenital Heart Disease 1984-2003." The Society for Thoracic Surgeons 40th Annual Meeting, San Antonio, TX. January 27 2003.

"Early and Medium Term Results With Repair of Ebstein’s Anomaly: The Columbia-Presbyterian Experience." American Association for Thoracic Surgery. 83rd Annual Meeting. Boston, MA. May 6, 2003.

"The diminishing impact of pretransplant pulmonary hypertension on perioperative mortality after cardiac transplantation." International Society for Heart and Lung Transplantation, 21st Annual Meeting and Scientific Sessions. Vancouver BC, Canada. April 27, 2001,

"Do donor characteristics really matter? Analysis of consecutive heart donors 1995-1999." International Society of Heart and Lung Transplantation 20th Annual Meeting and Scientific Sessions, Osaka Japan, April 7, 2000.

"Low Dose Vasopressin As Salvage Therapy for Marginal Donors." UNOS Region 9 Annual Transplant Forum, New York , NY. April 30, 1999.

"Physiologic low dose arginine vasopressin (AVP) 'replacement' therapy salvages hemodynamically unstable organ donors." The American Heart Association, 71st Annual Scientific Sessions, Dallas, TX November 11, 1998.

"Factor IX inhibition during primate cardiopulmonary bypass reduces complement, platelet and leukocyte activation compared with heparin." The American Heart Association, 71st Annual Scientific Sessions, Dallas, TX November 11, 1998.

"What is minimally invasive about 'minimally invasive' cardiac surgery? Separate contributions of cardiopulmonary bypass and sternotomy to the inflammatory response is suggested in a primate model." The American Heart Association, 71st Annual Scientific Sessions, Dallas, TX November 11, 1998.

"Arginine Vasopressin (AVP) is Deficient in Hemodynamically Unstable Organ Donors and AVP Replacement Increases Blood Pressure and Reduces Pressor Requirements." The International Society for Heart and Lung Transplantation, 18th Annual Sessions, Chicago, IL., April 16, 1997.

"Improved Survival Rates Support LVAD Implantation Early After Myocardial Infarction." The International Society for Heart and Lung Transplantation, 18th Annual Sessions, Chicago, IL., April 17, 1998.

"Bridge to Recovery: Improved Survival in Patients with Acute Viral Myocarditis Using Temporary External Pulsatile Ventricular Support." The International Society for Heart and Lung Transplantation, 18th Annual Sessions, Chicago, IL., April 17, 1998.

"What factors truly affect waiting time to transplantation? A multivariable analysis of the ISHLT/UNOS Thoracic Registry." The American Associaation for Thoracic Surgery 77th Annual Meeting. Washington, D.C. April 11, 1997.

"Angio-Access for hemodialysis: the perpetual problem of graft patency." The First Northeastern Conference on Angio-access for Hemodialysis. New York, NY. October 25, 1996.

"Is immediate biventricular support superior to solitary left ventricular support? Improved posttransplant survival despite perioperative right sided circulatory failure (RSCF)." The International Society for Heart and Lung Transplantation, sixteenth annual meeting and scientific sessions. New York, NY. March 16, 1996.

"Preoperative pulmonary hemodynamic characteristics but not reversibility with nitroprusside are highly correlated with 30-day mortality." The International Society for Heart and Lung Transplantation, fifteenth annual meeting and scientific sessions. San Francisco, CA. April 6, 1995.

"Multivariable analysis of factors affecting waiting time to heart transplantation." The American Heart Association, 66th annual meeting and scientific sessions, Dallas, TX. November, 1994.

"Experience with the Abiomed BVS 5000 for right sided circulatory failure after cardiac transplantation and left ventricular assist device insertion." Circulatory Support 1994, Pittsburgh, PA., October 28, 1994.

"Thromboembolism in patients with textured surface LVADs: a case-control transcranial doppler study." The International Society for Heart and Lung Transplantation, fourteenth annual meeting and scientific sessions. Venice, Italy. March 25, 1994.

"Molecular genetic anlaysis demonstrates three distinct categories of post-transplantation lymphoproliferative disorders." The International Society for Heart and Lung Transplantation, fourteenth annual meeting and scientific sessions. Venice, Italy. March 24, 1994.

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