Jessica Kandel, MD - Department of Surgery

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Jessica Kandel, MD

Positions and Appointments
2009-present		R. Peter Altman Professor of Surgery & Pediatrics (in the Institute for Cancer Genetics)
2009-present		Columbia University College of Physicians and Surgeons , New York, NY
2003-present		Attending Surgeon
2003-present		Morgan Stanley Children's Hospital of NewYork-Presbyterian Hospital, New York, NY

Clinical Specialties

General pediatric surgery and neonatal surgery
Pediatric tumor surgery
Pediatric vascular anomalies

Research Interests

Regulation of angiogenesis in pediatric solid tumors, including Wilms Tumor and neuroblastoma

Our laboratory investigates regulation of angiogenesis in models of pediatric cancer. In particular, we focus on the response to sustained disruption of vascular endothelial growth factor (VEGF) signaling, and examine how this interacts with the status of known oncogenic pathways.

Education and Training
July 1993-June 1995		Fellowship, Pediatric Surgery
July 1993-June 1995		Johns Hopkins Medical Center, Baltimore, MD
1986-1989; 1991-1993		Internship/Residency, General Surgery
1986-1989; 1991-1993		Massachusetts General Hospital, Boston, MA
July 1989-June 1991		Surgical Research Fellowship
July 1989-June 1991		Boston Children's Hospital, Boston, MA
1985		MD
1985		Columbia University College of Physicians & Surgeons, New York, NY
1981		BA, Summa Cum Laude
1981		Yale University, New Haven, CT

Professional Experience

2003-2009		Associate Professor of Surgery (in the Institute of Cancer Genetics)
2003-2009		Columbia University College of Physicians and Surgeons, New York, NY
2000		Director, Charles Edison Laboratory for Pediatric Surgical Research
2000		Columbia University, New York, NY

Professional Honors

Harold and Golden Lamport Award for Clinical Research, May 2003, Columbia University

Visiting Professor, Japanese Society for Pediatric Oncology, November 2003

Resident's Prize, American Academy of Pediatrics Surgical Section, Oct. 2000, "Combination Anti-Angiogenic Therapy"

Peter Paul Rickham Prize, British Association of Paediatric Surgeons, July 1999, "Anti-VEGF Antibody Suppresses Primary Tumor Growth and Metastasis in an Experimental Model of Wilms Tumor"

National Institutes of Health Training Grant, 1985

Upjohn Award for Excellence in Research, Columbia University College of Physicians & Surgeons, 1985

Phi Beta Kappa, 1981

Professional Societies and Committees

*Pediatrics Editor, Cancer Investigation
*Member, National Cancer Institute IRB (pediatrics)
*Member, Society for University Surgeons
*Member, American Pediatric Surgical Association,
Program Committee, 2001
*Chair, Publications Committee, Surgical Section,
American Academy of Pediatrics, 2001
*Member, Society for Pediatric Research, 2000
*Member, National Wilms Tumor Study Group

Selected Publications

Image-guided esophageal anastomosis in esophageal atresia. Garcia AV, Thirumoorthi AS, Traina JM, Schlossberg P, Sheynzon V, Kandel JJ. J Pediatr Surg. 2012 Oct;47(10):1959-61. doi: 10.1016/j.jpedsurg.2012.05.019.

Congenital Cutaneous Hemangioma Causing Cardiac Failure: A Case Report and Review of the Literature. Weitz NA, Lauren CT, Starc TJ, Kandel JJ, Bateman DA, Morel KD, Meyers PM, Kadenhe-Chiweshe A, Wu JK, Garzon MC. Pediatr Dermatol. 2012 Oct 2. doi: 10.1111/j.1525-1470.2012.01875.x. [Epub ahead of print]

A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastoma. Cheng WY, Kandel JJ, Yamashiro DJ, Canoll P, Anastassiou D. PLoS One. 2012;7(4):e34705. Epub 2012 Apr 6.

Severe Mycoplasma pneumoniae infection requiring extracorporeal membrane oxygenation with concomitant ischemic stroke in a child. Garcia AV, Fingeret AL, Thirumoorthi AS, Kadenhe-Chiweshe A, Kandel JJ. Pediatr Pulmonol. 2012 Mar 29. doi: 10.1002/ppul.22552. [Epub ahead of print]

Contrast ultrasound imaging for identification of early responder tumor models to anti-angiogenic therapy. Sirsi SR, Flexman ML, Vlachos F, Huang J, Hernandez SL, Kim HK, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Hielscher AH, Kandel JJ, Yamashiro DJ, Borden MA. Ultrasound Med Biol. 2012 Jun;38(6):1019-29. Epub 2012 Mar 16.

Monitoring early tumor response to drug therapy with diffuse optical tomography. Flexman ML, Vlachos F, Kim HK, Sirsi SR, Huang J, Hernandez SL, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Borden MA, Yamashiro DJ, Kandel JJ, Hielscher AH. J Biomed Opt. 2012 Jan;17(1):016014.

Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo.

Anastassiou D, Rumjantseva V, Cheng W, Huang J, Canoll PD, Yamashiro DJ, Kandel JJ. Cancer. 2011 Dec 30;11:529. PMID: 22208948 [PubMed - indexed for MEDLINE] Free PMC Article
Related citations

Notch: a key regulator of tumor angiogenesis and metastasis. Garcia A, Kandel JJ. Histol Histopathol. 2012 Feb;27(2):151-6. Review.

Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. Fisher JC, Gander JW, Haley MJ, Hernandez SL, Huang J, Chang YJ, Johung TB, Guarnieri P, O'Toole K, Yamashiro DJ, Kandel JJ. Vasc Cell. 2011 Oct 6;3:22.

Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors. Sirsi SR, Hernandez SL, Zielinski L, Blomback H, Koubaa A, Synder M, Homma S, Kandel JJ, Yamashiro DJ, Borden MA. J Control Release. 2012 Jan 30;157(2):224-34.

Contrast-enhanced sonography as a novel tool for assessment of vascular malformations. Yukiko Oe, Lauren Orr, Sherelle Laifer-Narin, Eiichi Hyodo, Agnes Koczo, Shunichi Homma, Jessica Kandel and Philip Meyers. J Angiogenesis Res. 2010 (in press)

Comparing Tumor Response to VEGF Blockade Therapy using High Frequency Ultrasound Imaging with Size-Selected Microbubble Contrast Agents. Shashank Sirsi, Cherry Chen, Sonia Hernandez, Jianzhong Huang, Tessa Johung, Darrell Yamashiro, Jessica Kandel, Shunichi Homma, Mark Borden. 2010 IEEE Ultrasonics Symposium Proceedings (in press).

PDE-constrained multispectral imaging of tissuechromophores with the equation of radiative transfer. Kim HK, Flexman M, Yamashiro DJ, Kandel JJ, Hielscher AH. Biomedical Optics Express Vol. 1, Iss. 3, pp. 812-824 (2010)

Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. Boo YJ, Fisher JC, Haley MJ, Cowles RA, Kandel JJ, Yamashiro DJ. J Pediatr Surg. 2009 Oct;44(10):2031-6.

Neonatal Hepatic Mesenchymal Hamartoma Causing Cardiac Failure and Disseminated Intravascular Coagulopathy. Wan P, Susman J, Kandel J, Jan D, Jerome EH, Parravicini E. Am J Perinatol. 2009 Apr 15.

Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma. Zaghloul N, Hernandez SL, Bae JO, Huang J, Fisher JC, Lee A, Kadenhe-Chiweshe A, Kandel JJ, Yamashiro DJ. Int J Oncol. 2009 Feb;34(2):401-7.

Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Huang J, Bae JO, Tsai JP, Kadenhe-Chiweshe A, Papa J, Lee A, Zeng S, Kornfeld ZN, Ullner P, Zaghloul N, Ioffe E, Nandor S, Burova E, Holash J, Thurston G, Rudge J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Int J Oncol. 2009 Jan;34(1):79-87.

Huang J, Frischer JS, New T, Kim ES, Serur A, Lee A,
Kadenhe-Chiwishe A, Pollyea DA, Yokoi A, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol Cancer Ther. 2004 Mar;3(3):335-43.

Frischer JS, Huang J, Serur A, Kadenhe A, Yamashiro DJ,
Kandel JJ. Biomolecular markers and involution of hemangiomas. J Pediatr Surg. 2004 Mar;39(3):400-4.

Davidoff AM, Kandel JJ. Antiangiogenic therapy for the treatment of pediatric solid malignancies. Semin Pediatr Surg. 2004 Feb;13(1):53-60.

Huang J, Soffer SZ, Kim ES, McCrudden KW, Huang J, New T, Manley CA, Middlesworth W, O'Toole K, Yamashiro DJ, Kandel JJ.

Vascular remodeling marks tumors that recur during chronic
suppression of angiogenesis. Mol Cancer Res. 2004 Jan;2(1):36-42.

Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'toole K, Yamashiro DJ, Kandel JJ. Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/neu-expressing experimental Wilms' tumor. J Pediatr Surg. 2003 Nov;38(11):1569-73.

Kaicker S, McCrudden KW, Beck L, New T, Huang J, Frischer JS, Serur A, Kadenhe-Chiweshe A, Yokoi A, Kandel JJ, Yamashiro DJ. Thalidomide is anti-angiogenic in a xenograft model of neuroblastoma. Int J Oncol. 2003 Dec;2 (6):1651-5.

Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'Toole K, Yamashiro DJ, Kandel JJ. Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor.Oncol Rep. 2003 Sep-Oct;10(5):1271-4.

Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O'Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7785-90. Epub 2003 Jun 12.

Glade-Bender J, Kandel JJ, Yamashiro DJ. VEGF blocking therapy in the treatment of cancer. Expert Opin Biol Ther. 2003 Apr;3(2):263-76.

McCrudden KW, Hopkins B, Frischer J, Novikov A, Huang J,
Kadenhe A, New T, Yokoi A, Yamashiro DJ, Kandel JJ, Middlesworth W. Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis. J Pediatr Surg. 2003 Mar;38(3):308-14; discussion 308-14.

Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11399-404. Epub 2002 Aug 12.

McCrudden KW, Yokoi A, Thosani A, Soffer SZ, Kim ES, Huang J, Manley C, O'toole K, Yamashiro DJ, Kandel JJ, Middlesworth W. Topotecan is anti-angiogenic in experimental hepatoblastoma. J Pediatr Surg. 2002 Jun;37(6):857-61.

Huang J, Soffer SZ, Kim ES, Yokoi A, Moore JT, McCrudden KW, Manley C, Middlesworth W, O'Toole K, Stolar C, Yamashiro DJ, Kandel JJ. p53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease. J Pediatr Surg. 2002 Mar;37(3):523-7.

Kim ES, Soffer SZ, Huang J, McCrudden KW, Yokoi A, Manley CA, Middlesworth W, Kandel JJ, Yamashiro DJ. Distinct response of experimental neuroblastoma to combination antiangiogenic strategies. J Pediatr Surg. 2002 Mar;37(3):518-22.

Soffer SZ, Kim E, Huang J, McCrudden K, Yokoi A, Moore JT, Manley C, O'Toole K, Middlesworth W, Stolar C, Yamashiro DJ, Kandel JJ. Resistance of a VEGF-producing tumor to anti-VEGF antibody: unimpeded growth of human rhabdoid tumor xenografts. J Pediatr Surg. 2002 Mar;37(3):528-32.

Kim, Moore, Huang, Soffer, Manley, O'Toole, Middlesworth, Stolar, Kandel and Yamashiro. All angiogenesis is not the same: Distinct patterns of response to antiangiogenic therapy in experimental neuroblastoma and Wilms tumor.J Pediatr Surg. 2001. 36: 287-90.

Huang, Moore, Soffer, Kim Rowe, Manley, 0'Toole, Middlesworth, Stolar, Yamashiro and Kandel, Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors. J Pediatr Surg. 2001, 36:357.61.

Soffer, Moore, Kim, Huang, Yokoi, Manley, O'Toole, Stolar, Middlesworth, Yamashiro and Kandel. Combination antiangiogenic therapy: increased efficacy in a marine model of Wilms tumor. J Pediatr Surg. Aug, 2001. 36:1177-81

Moore, Lee, Garzon, Soffer, Kim, Saouaf, del Toro, Yamashiro and Kandel. Effective therapy of a vascular tumor of infancy with vincristine. J Pediatr Surg. 2001. 36: 1273-6.

Dr. Kandel co-organized the first Columbia University Arden House Symposium on Angiogenesis, held July 13-15, 2001 with Drs. Jan Kitajewski, Ann Marie Schmidt, and George Yancopoulos.

(Visit PubMed to view this faculty member's most recent articles.)