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Jay H. Lefkowitch, MD

Positions and Appointments

1988-present  Professor of Clinical Pathology
Columbia University College of Physicians & Surgeons, New York, NY
1988-present  Attending Pathologist
NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY

Education and Training

1978-1979  Visiting Fellow in Liver Pathology
Royal Free Hospital, London, England
1977-1980  Resident, Department of Pathology
Columbia Presbyterian Medical Center, New York, NY
1976-1977  Intern, Department of Pathology
Columbia Presbyterian Medical Center, New York, NY
1976  MD
Columbia University College of Physicians & Surgeons, New York, NY
1972  BA in Fine Arts, summa cum laude
Clark University, Worcester, MA

Board Certifications

American Board of Pathology, 1980

Professional Experience

1986-1988  Associate Professor of Pathology
Columbia University College of Physicians & Surgeons, New York, NY
1980-1986  Assistant Professor of Pathology
Columbia University College of Physicians & Surgeons, New York, NY
1978-1979  Honorary Assistant Lecturer in Histopathology
Royal Free Hospital School of Medicine, University of London, London, England
1978-1979  Honorary Clinical Registrar
Department of Histopathology, Royal Free Hospital, London, England

Professional Honors

Teacher of the Year (Second Year Class), 1985 1988, 1992, 1994, 1995, 2000, 2004

Gender Equity Award from American Medical Women's Association, 1995, 1999, 2000

Presidential Teaching Award from Columbia University, 2000

Charles Bohmfalk Award for Distinguished Teaching in the Clinical Years, May 1995

Distinguished Teacher Award, Graduating Class of Columbia University College of Physicians & Surgeons, 1983, 1997

Dean's Biochemical Research Study Grant, 1981, 1982, 1983

Phi Beta Kappa, 1971

Harold Lee Meierhoff Memorial Prize in Pathology, Columbia University College of Physicians & Surgeons

Joseph Garrison Parker Award in the Arts, Columbia University College of Physicians & Surgeons

Professional Societies and Committees

American Association for the Study of Liver Diseases,
1980-present

American Association of Pathologists, 1982-present

International Association of Pathologists, 1987-present

International Working Party on the Nomenclature of Chronic Hepatitis and Hepatic Nodules (for Presentation at World Congress of of Gastroenterology, Oct. 1994, Los Angeles, CA, USA), Member, 1993-1994

New York Physicians' Art Association (President), 1985-1987

Training and Education Committee, American Association
for the Study of Liver Diseases (AASLD), 1996-1999


Selected Publications

Turkish A, Levy J, Kato M, Granowetter L, Ruzal-Shapiro C, Berdon W, Sussman J, Lefkowitch J. Pancreatitis and probable paraneoplastic cholestasis as presenting manifestations of pancreatic lymphoma: evaluation, management, and clinical course in a child. J Ped Gastroenterol Nutr 2004; 39: 552-556.

Eleazar JA, Memeo L, Jhang JS, Mansukhani MM, Chin S, Park SM, Lefkowitch JH, Bhagat G. Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis. J Hepatol 2004; 41: 983-991.

Gaglio P, Malireddy S, Levitt BS, Lapointe-Rudow D, Lefkowitch J, Kinkhabwala M, Russo MW, Emond JC, Brown RS Jr. Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors. Liver Transplant 2003; 9: 1028-1035.

Kumar KS, Lefkowitch J, Russo MW, et al. Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis. Gastroenterol 2002; 122: 2026-2031.

Lefkowitch JH, Haythe JH, Regent N. Kupffer cell aggregation and perivenular distribution in steatohepatitis. Modern Pathol 2002; 15: 699-704.

May LD, Lefkowitch JH, Kram MT, Rubin DE. Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy. Ann Intern Med 2002; 136: 449-452.

Yeh YA, Rao PH, Cigna CT, Middlesworth W, Lefkowitch JH, Murty VVVS. Trisomy 1q,2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements. Cancer Gen Cyto 2000; 123: 140-143.

Marvin MR, Lefkowitch J, Ishak KG, Chabot J. Long-term survival of a young woman with peripheral cholangiocarcinoma: a case report. J Clin Gastroenterol 1999; 28: 64-66.

Arnon R, Yoshimura T, Reiss A, Budai K, Lefkowitch JH, Javitt NB. Cholesterol 7 hydroxylase Knockout mouse: a model for monohydroxy bile-acid related neonatal cholestasis. Gastroenterology 1998; 115: 1223-1228.

Lefkowitch JH, Yee HT, Sweeting J, Green PHR, Magun AM. Iron rich foci in chronic viral hepatitis. Hum Pathol 1998; 29: 116-118.

Yano M, Kumeda H, Kage M. Ikeda K, Shimamatsu K, Inoue O. Hashimoto E, Lefkowitch JH, Ludwig J, Okuda K. The long term pathological evolution of chronic hepatitis C. Hepatology 1996; 23: 1334 1340.

Lefkowitch JH, Schiff ER. Davis GL, et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. Gastroenterology 1993; 104: 595 603.

Perrillo RP, Schiff ER, Davis GL et al. A randomized, controlled trial of interferon alfa 2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323: 295 301.

Davis GL. Balart LA, Schiff ER, et al. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. N Engl J Med 1989; 321:1501 1506.

Foitl DR. Hyman GH. Lefkowitch JH. Jaundice and intrahepatic cholestasis following high dose megestrol acetate for breast cancer. Cancer 1989; 63 :438 439.

Knobler EH. Silvers DN, Fine KC, Lefkowitch JH, Grossman ME. Unique vascular skin lesions associated with the human immunodeficiency virus. JAMA 1988; 260: 524 527.

Lefkowitch JH. Apfelbaum TF. Non A, non B hepatitis: Characterization of liver biopsy pathology. J Clin Gastroenterol 1989; 11: 225 232.

Lefkowitch JH, Apfelbaum TF. Liver cell dysplasia and hepatocellular carcinoma in non A, non B hepatitis. Arch Pathol Lab Med 1987; 111: 170 173.

Lederman SM. Martin EC. Laffey KT, Lefkowitch JH. Hepatic neurofibromatosis. malignant schwannoma and angiosarcoma in von Recklinghausen's disease. Gastroenterology 1987; 92: 234 239.

Lefkowitch JH, Goldstein H. Yatto R, Gerber MA. Cytopathic liver injury in acute delta hepatitis. Gastroenterology 1987; 92: 1262 1266.

(Visit PubMed to view this faculty member's most recent articles.)

TEXTBOOKS

Scheuer PJ and Lefkowitch JH. Liver Biopsy Interpretation, 7th Edition. Edinburgh: Elsevier, In Press for 2005 publication.

Scheuer PJ, Lefkowitch JH. Liver Biopsy Interpretation. 6th Ed. London and Philadelphia: W.B. Saunders Co., 2000.

Scheuer PJ, Lefkowitch JH. Liver Biopsy Interpretation. 5th Ed. London and Philadelphia: W.B. Saunders Co., 1994.

Lefkowitch JH. Histopathology of Disease. New York: Churchill Livingstone, 1989.

King DW, Fenoglio CM, Lefkowitch JH. General Pathology. Principles and Dynamics. Philadelphia: Lea and Febiger 1983.

King DW, Geller LM, Krieger P, Silva F, Lefkowitch JH. A Survey of Pathology. New York: Oxford University Press 1976.

REVIEWS/BOOK CHAPTERS

Lefkowitch JH. Hepatobiliary pathology. Curr Op Gastroenterol 2003; 19: 185-193.

Lefkowitch JH. Hepatobiliary pathology. Curr Op Gastroenterol 2002; 18: 290-298.

Lefkowitch JH (Guest Editor). Liver Histopathology. Clin Liver Dis 6: 2002.

Lefkowitch JH. Histologic hallmarks of alcoholic hepatitis. In Nonalcoholic and Alcoholic Steatohepatitis. The Netherlands: Kluwer Academic Publishers, 2001.

Ludwig J, Lefkowitch JH. Histopathology of the liver following transplantation. In: Liver Transplantation. Schiff E et al, Eds. Philadelphia: W.B. Saunders Co. (2001).

Bhagat G, Lefkowitch JH. Grading and staging of chronic hepatitis. Pathol Case Rev 1999; 4: 109-116.

Lefkowitch JH. Hepatic granulomas. J Hepatol 1999; 30 Suppl 1: 40-45.

Lefkowitch JH. Pathology of the liver. Curr Op Gastroenterol 1998; 14: 191-199.

Lefkowitch JH. Acute and chronic hepatitis: current concepts and classification. Res Staff Phys 1997; 43: 11-16.

Lefkowitch JH. Biliary atresia. Mayo Clin Proc 1998; 73: 90-95.

(Visit PubMed to view this faculty member's most recent articles.)






Address:
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PH Room PH-14
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Phone: 212-305-7381
Fax: 212-305-5498


jhl3@columbia.edu



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