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Jonathan Javitch, MD/PhD
Lieber Professor of Psychiatry and Professor of Pharmacology (in the Center for Molecular Recognition and in Physiology & Cellular Biophysics)
Chief, Division of Molecular Therapeutics,
New York State Psychiatric Institute
Director, Lieber Center for Schizophrenia Research,
Columbia University Medical Center
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Jonathan A. Javitch obtained his B.S. and M.S. in Biological Sciences at Stanford University. He completed the joint M.D.-Ph.D. program at the Johns Hopkins University School of Medicine where as a graduate student with Solomon Snyder he demonstrated that a key step in the Parkinson’s-like neurotoxicity of MPTP is the uptake of its metabolite MPP+ by the dopamine transporter. After graduating from Hopkins, Dr. Javitch completed a medical internship and psychiatric residency at the Columbia Presbyterian Hospital and the New York State Psychiatric Institute. He did postdoctoral work on the structure of dopamine receptors with Dr. Arthur Karlin at Columbia University.
Dr. Javitch is currently Lieber Professor of Psychiatry and Professor of Pharmacology in the Center for Molecular Recognition and in Physiology and Cellular Biophysics at the Columbia University College of Physicians and Surgeons, Director of the Lieber Center for Schizophrenia Research, and Chief of the Division of Molecular Therapeutics at the New York State Psychiatric Institute. His laboratory focuses on understanding the structure, function, and regulation of G-protein coupled receptors and neurotransmitter transporters. During the last five years his group has begun to map, for the first time, the transmembrane interfaces of dopamine D2 receptor homo-oligomers in the plasma membrane and has identified conformational changes at the interface that determine receptor activation. More recently his group has demonstrated that phosphorylation of the amino-terminus of the dopamine transporter is essential for amphetamine-mediated reverse transport of dopamine, and he and his collaborators have begun to elucidate the molecular mechanisms that govern this regulation. He is now pursuing studies in knock-in mice and transgenic flies to explore these mechanisms in a physiological context. His laboratory is also taking direct structural approaches to studying the structure and dynamics of bacterial transporter homologues of the human neurotransmitter transporters.
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Undergraduate: Stanford University, B.S., M.S., 1976-1980
Graduate: Johns Hopkins University, Ph.D. Pharmacology, 1980-1986
Medical School: Johns Hopkins University, M.D., 1980-1986
Internship: Columbia University Medical Center, Medical Internship, 1986-1987
Residency: Columbia University Medical Center, Psychiatry, 1987-1990
Fellowship: Columbia University Medical Center, Schizophrenia fellow, 1990-1992
Board Certifications: Psychiatry
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Address:
P & S
Room 11-401 Unit/Box:7
630 West 168th St.
New York, NY 10032
Phone: 212-305-7308
Fax: 775-898-5133
jaj2@columbia.edu
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| Structure, function and regulation of G protein coupled receptors and neurotransmitter transporters - the targets for antipsychotic drugs and psychostimulants.
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1. Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA: Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.. Nature Chemical Biology 2009;5: 688-95
2. Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA: Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.. Proc Natl Acad Sci U S A. 2009;106: 5563-8
3. Guo, W., Urizar, E., Kralikova, M., Mobarec, J.C., Shi, L., Filizola, M., Javitch, J.A.: Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO Journal 2008;27: 2293-2304
4. Shi, L., Quick, M., Zhao, Y., Weinstein, H., Javitch, J.A. : The mechanism of a neurotransmitter:sodium symporter – inward release of Na+ and substrate is triggered by substrate in a second binding site. Molecular Cell 2008;30: 667-677
5. Zomot, E., Bendahan, A., Quick, M., Zhao, Y., Javitch, J.A., Kanner, B.I. : Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature 2007;449: 726-730
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FACULTY ONLY
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