Holly Moore, Ph.D.

Associate Professor of Clinical Neurobiology in Psychiatry

Associate Professor of Clinical Neurobiology in Psychiatry,
Columbia University

Director Laboratory Resource Management,
New York State Psychiatric Institute

Director, Rodent Neurobehavioral Analysis Core,
New York State Psychiatric Institute

Education and Training:

• Undergraduate:  Wright State University, B.S., -1990
• Graduate:  Ohio State University, PhD, 1990-1995
• Fellowship:  University of Pittsburgh, PhD, 1995-1998
• Post-Graduate:  University of Pittsburgh, PhD, 1998-2002

Specialties:

• Preclinical models of mood and psychotic disorders
• Rodent behavioral assessment and psychopharmacology
• Neurophysiology and neurochemistry of dopamine systems

Contact Information:

Address:
NYS Psychiatric Institute
Room 5913  Unit/Box:14
1051 Riverside Drive
New York, NY   10032

Phone: 212-543-6938
Fax: 212-543-1017
hm2035@columbia.edu

Research Summary:

The Moore laboratory uses rodent and non-human primate preparations to model potential pathogenic mechanisms and treatment targets in schizophrenia and affective disorders. Specifically we focus on neurobehavioral systems, relating structural neuropathology to neural circuit function and, ultimately to behavior.

Publications:

1. Cressman VL, Balaban J, Steinfeld S, Shemyakin A, Graham P, Parisot N, Moore H. : Cressman VL, Balaban J, Steinfeld S, Shemyakin A, Graham P, Parisot N, Moore H. Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.  Journal of Comparative Neurology  2010;518: 2693-2709

2. Glickstein, SB, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, Ross ER: Selective cortical interneuron and GABA deficits in cyclin D2-null mice.  Development  2007;134: 4083-4093

3. Kellendonk C, Simpson EH, Polan HJ, Malleret G, Vronskaya S, Winiger V, Moore H, Kandel ER : Transient and selective over-expression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortical functioning.  Neuron  2006;49: 603-615

4. Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA: A neurobehavioral systems analysis of the effects of gestational exposure to methylazoxymethanol acetate (MAM) in the rat: implications for the neuropathology of schizophrenia..  Biolical Psychiatry  2006;60: 253-264

5. Moore, H.: The role of rodent models in the discovery of new treatments for schizophrenia: Updating our strategy
.  Schizophrenia Bulletin  2010;36: 1066-1072