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Research Summary
Research interests include the clinical and translational study of gastrointestinal tumor genetics and biology.
Research Activities
Current research protocols include:
- a registry, blood and tumor repository for pancreas cancer and high-risk patients;
- secretin-enhanced imaging of the pancreas for early detection of pancreas cancer in high-risk individuals;
- the pathophysiological study of pancreatic endocrine function as an early pancreas cancer detection modality;
- the use of secretin-enhanced MRI (magnetic resonance imaging) in determining the degree of exocrine pancreas insufficiency after pancreas cancer resection;
- a high-risk pancreas cancer prevention and genetics program;
- the impact of gastric acid suppression medications on the development of gastric polyps;
- the use and risk of gastrointestinal endoscopy in patients scheduled for cardiac catheterization and possible coronary stent placement;
- the use of PET scanning in differentiating benign from malignant pancreas lesions.
Ongoing translational research activities include:
- investigations of the role of p16 and Rb genetic mutations in pancreatic cancer;
- the role of BRCA mutations and modifier genes in Ashkenazi Jews with pancreas cancer;
- the prognostic effect of pre-neoplastic pancreas lesions in patients who have undergone pancreas cancer resection;
- the molecular genetics of preneoplastic pancreas lesions;
- the use of stool DNA markers in the early detection of pancreas cancer.
Education and Training
| 1982 |
M.D. |
SUNY Health Sciences Center at Syracuse, Syracuse, NY |
| 1982-1985 |
Internal Medicine |
SUNY Health Sciences Center at Syracuse, |
| 1985-1986 |
Gastroenterology |
SUNY Health Sciences Center at Syracuse, |
| 1986-1991 |
Gastroenterology |
DDB, NIDDK, NIH, |
Honors and Awards
2009 – 2010 Irving Institute for Clinical and Translational Research/CTSA Imaging Core Pilot Project. “PET Scans for the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms (IPMN) of the Pancreas”. Mentor. (Principal Investigator - Dr. Caroline Hwang).
2006 – 2007 Hirshberg Foundation for Pancreatic Cancer Research Seed Grant
2003 – 2004 Columbia Presbyterian Medical Center Herbert IrvingComprehensive Cancer Center Pilot Award
Special Interests
Interests include:
- pancreas cancer screening, early detection, prevention, and genetics;
- colon cancer screening, early detection, prevention, and genetics;
- inherited gastrointestinal cancer and polyposis syndromes;
- genetic counseling and genetic testing;
- gastric acid hypersecretory states such as Zollinger-Ellison syndrome and gastrinoma;
- neuroendocrine tumors;
- the clinical effects of cancer and cancer treatment on the GI tract.
Areas of expertise:
Cancer Genetics
Inherited and Familial Cancer Syndromes
Cancer Screening, Prevention, and Early Detection
Pancreatic Cancer
Neuroendocrine Tumors
Zollinger-Ellison Syndrome
Selected Publications:
1. Calvert P, Frucht H. (2002) The genetics of colorectal cancer. Ann. Intern. Med.
137:603-12
2. Cheng K, Chen Y, Zimniak P, Raufman J-P, Xiao Y, Frucht H. (2002) Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line. Biochim. Biophys. Acta.
1588:48-55
3. Yang W-L, Frucht H. (2001) Activation of the PPAR pathway induces apoptosis and cox2 inhibition in HT-29 human colon cancer cells. Carcinogenesis
22:1379-83
4. Yang W-L, Frucht H. (2000) Cholinergic receptor up-regulates cox2 expression and prostaglandin E2 production in colon cancer cells. Carcinogenesis
21:1789-93
5. Frucht H, Jensen RT, Dexter D, Yang W-L, Xiao Y. (1999) Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clin. Cancer Res.
5:2532-9
6. Frucht H, Stevens PD, Fogelman DR, Verna EC, Chen J, Chabot JA, Fine RL. (2004) Advances in the Genetic Screening, Work-Up, and Treatment of Pancreatic Cancer Current Treatment Options in Gastroenterology
7:343-354
7. Vinarsky V, Fine R, assaad A, Qian Y, Chabot JA, su G, Frucht H. (in press) Head and Neck Aquamous Cell Carcinoma in FAMMM Syndrome Head and Neck
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8. Gatto NM, Frucht H, Sundararajan V, Jacobson JS, Grann VR, Neugut AI (2003) Risk of Perforation Following Colonoscopy and sigmoidoscopy: A Population Based Study Journal of the National Cancer Institute
95:230-236
9. Frucht H, Gazdar AF, Park JA, Oie H, Jensen RT (1992) Characterization of Functional Receptors for Gastrointestinal Hormones on Human Colon Cancer Cell Lines Cancer Research
52:1114-1122
10. Frucht H, Norton JA, London JF, Vinayek R, Doppman JL, Gardner JD, Jensen RT, Maton PN (1990) Detection of Duodenal Gastrinomas by Operative Endoscopic Transillumination. A Prospective Study Gastroenterology
99:1622-1627
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