My research is focused on osteoporosis and other disorders of bone and mineral metabolism. I am particularly interested in the multiple intersections between the skeleton and other diseases (such as HIV/AIDS) and medications (glucocorticoids, cyclosporines, heparin).
A major interest is transplantation and its effects on the skeleton. We have just completed a randomized clinical trial comparing bisphosphonates (oral alendronate) and calcitriol for prevention of bone loss after heart transplantation. This study will be published in the New England Journal Medicine. New studies will be starting up looking at intravenous zoledronate in various forms of organ transplantation.
Another interest is in the bone disease of HIV/AIDS in children and adolescents and adults, particularly postmenopausal women. We have two ongoing studies in this area.
We have an investigator-initiated study comparing transdermal estrogen and bisphosphonates for prevention and treatment of osteoporosis in men with prostate cancer received anti-androgen therapy.
We are in process of applying for NIH-funding for a study of the form of idiopathic osteoporosis that occurs in premenopausal women. This is an in-depth study (a bone biopsy study) of bone quality and quantity in this unusual disorder.
1. Kulak CAM, Schussheim DH, McMahon DJ, et al. (2000) Osteoporosis and low bone mass in premenopausal and perimenopausal women. Endocrine Practice
2. Shane E, Rodino M, McMahon DJ, et al. (1998) Prevention of bone loss after cardiac transplantation with antiresorptive therapy: a pilot study. J Heart Lung Transplant
3. Shane E, Mancini D, Aaronson K, et al. (1997) Bone mass, vitamin D deficiency and hyperparathyroidism in congestive heart failure. Am J Med
4. Shane E, Rivas M, McMahon DJ, et al. (1997) Bone loss and turnover after cardiac transplantation. J Clin Endocrinol Metab
5. Shane E, Rivas M, Staron RB, et al. (1996) Fracture after cardiac transplantation: A prospective longitudinal study. J Clin Endocrinol Metab