E. David Leonardo, M.D., Ph.D.
Assistant Professor of Psychiatry at CUMC, Division of Integrative Neuroscience
Dr. Leonardo graduated from Yale University and received his M.D. and Ph.D. from the University of California at San Francisco.
He completed residency training at NYSPI/Columbia University, College of Physicians & Surgeons. He completed a Research Fellowship in Anxiety, Mood and related disorders under the mentorship of Dr. Rene Hen and has continued as faculty in the division of Integrative neuroscience since that time.
Undergraduate: Yale University, B.S., 1986-1990
Graduate: University of California, San Francisco, Ph.D., 1990-1999
Medical School: University of California, San Francisco, M.D., 1990-1999
Internship: New York Presbyterian Hospital/Columbia University, 1999-2000
Residency: Columbia University Medical Center/New York State Psychiatric Institute, 2000-2003
Fellowship: Columbia University Medical Center/New York State Psychiatric Institute, 2003-2006
Board Certifications: American Board of Psychiatry and Neurology in Psychiatry
• Mood Disorder
• Anxiety Disorders
NYSPI Kolb Annex
Room 157 Unit/Box:87
1051 Riverside Drive
New York, NY 10032
Our primary interest is in understanding how temporal factors, genetic risk, and environmental milieu interact to impact on the expression of mental illness. In another area of investigation we us novel, regulatable, serotonin-1A receptor mutant mice to disrupt normal serotonergic signaling in early development.
1. Richardson-Jones, J.W., Craige, C.P., Guiard, B.P., Stephen, A.K., Metzger, K.L., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Beck, S.G., Hen, R., and *Leonardo, E.D. : 5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants. Neuron 2010;65: 40-52
1. Dranovsky A, Leonardo ED.: Is there a role for young hippocampal neurons in adaptation to stress. Behav Brain Res 2012;227(2): 371-375
2. Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, Palme R, Griebel G, Ibarguen-Vargas Y, Hen R, Belzung C.: Antidepressants recruit new neurons to improve stress response regulation. Molecular Psychiatry 2011;16(12): 1177-1188