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Department of Medicine
Department of Medicine

Russ Berrie Pavilion
Room 238
1150 St.Nicholas Avenue
New York, NY   10032

Phone: 212-851-5322

-Department of Medicine
-Naomi Berrie Diabetes Center
-Columbia University Diabetes & Endocrinology Research Center
-Institute for Human Nutrition

Anthony W. Ferrante, Jr., MD, PhD
Dorothy & Daniel Silberberg Associate Professor of Medicine

Research Summary
Work in the Ferrante Laboratory has revealed that the immune system recognizes and responds to changes in metabolic function. Studies in the laboratory focus on how the immune and metabolic systems interact.

Research Activities
Metabolism, Obesity & the Immune System

For several decades it was known that obesity and related metabolic disorders increase the concentration inflammatory molecules found in the circulation and in key metabolic tissues. Studies in the Ferrante Laboratory revealed that the obesity-induced increases in inflammation are part of a complex immune response in which macrophages, T-cells and NK cells are recruited to metabolic organs and tissues during the development of \obesity, diabetes and non-alcoholic fatty liver disease. For example, in lean individuals macrophages constitute ~5% of the cells in adipose tissue, but in the most obese individuals 50% or more of the cells in a fat depot are macrophages. Studies from the Ferrante and other laboratories have demonstrated a close association of subpopulations of immune cells with the metabolic complications of obesity including diabetes and non-alcoholic fatty liver disease.

Much of the current work in the Ferrante Laboratory is focused on identifying and characterizing the immune cell populations that are altered by obesity and how the immune system regulates metabolism. By determining the adaptive and pathological functions of the immune system in metabolism, the laboratory identifies cells, pathways and molecules that are candidate targets for therapeutic interventions and that can be used to predict metabolic outcomes.

Education and Training
1985 Physics - BA Yale University, New Haven, CT
1995 Developmental Biology - PhD Albert Einstein College of Medicine, Bronx, NY
1995 Medicine - MD Albert Einstein College of Medicine, Bronx, NY
1998 Internal Medicine Columbia University Medical Center, New York, NY

Honors and Awards
Fellow’s Prize of Saybrook College, Yale University
1995 Alpha Omega Alpha, Albert Einstein College of Medicine
1998 Affymetrix Academic User Award (Declined)
1998-2000 Lucille P. Markey Charitable Trust Fellowship
2001 Naomi Berrie Diabetes Research Award
2006 Nature Medicine - Notable Advances in the Field of Metabolism (JCI 112; 1796-1808 [2003])
2006 Gill Cardiovascular Center Visiting Professor – University of Kentucky
2006 Gunnar Birke Lecture – Karolinska Institute
2006 Dorothy and Daniel Silberberg Endowed Assistant Professorship in Medicine
2009 John N. Loeb Lecture – Columbia University
2009 UK Adipose Tissue Society Meeting – Keynote Lecture
2010 Dean’s Emerging Concepts in Medicine Lecture - SUNY Downstate
2010 Harold & Golden Lamport Award for Excellence in Clinical Research - Columbia University

Committees and Society Memberships
Scientific Review Committee - American Diabetes Association
CSR - Intergrated Physiology of Obesity & Diabetes
CSR - NIDDK Collaborative Team Programs

Selected Publications:
1. Odegaard JI, *Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante Jr AW, Chawla A. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447 :1116-1120

2. *Odegaard JI, *Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante Jr AW, Chawla A. (2008) PPAR-delta controls alternative (M2) activation of Kupffer cells to ameliorate insulin resistance Cell Metabolism 7:496-507

3. Martinez de Victoria E, Xu X, Koska J, Francisco AM, Scalise M, Ferrante AW, Jr., Krakoff J (2009) Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians Diabetes 58:385-393

4. Obstfeld AE, Sugaru E, Thearle MS, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante Jr AW (2010) CCR2 regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis Diabetes 59:916-25

5. Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, Ferrante Jr AW. (2010) Weight Loss and lipolysis activate an immune response in mice Journal of Clinical Invesigation 120:3466-79

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