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Address:
P & S
Room 9-428
630 West 168th St.
New York, NY   10032

Phone: 212-342-4530

Affiliations
-Columbia University College of Physicians & Surgeons
-Department of Medicine
-Division of Infectious Diseases

Hospital Affiliations
New York Presbyterian Hospital


Anne-Catrin Uhlemann, MD, PhD
Assistant Professor of Medicine

Research Summary
Infectious Diseases, Staphylococcus aureus

Research Activities
The past decade has witnessed a dramatic increase in Staphylococcus aureus infections acquired from the community. Yet there remains a limited understanding of how these strains spread and subsequently become established and persist within communities.
My research is focused on identifying molecular mechanisms that allow epidemic S. aureus strains such as USA300 to successfully disseminate. This project uses a combined approach of whole-genome comparative sequencing of longitudinally collected samples, genetic manipulation, and functional studies on bacterial adhesion and survival. These molecular studies are informed by ongoing epidemiological studies on S. aureus transmission in the local community. This work has identified a potentially newly emerging S. aureus strain, ST398, which was previously only associated with close contacts to animals. Ongoing studies are aimed at elucidating the molecular mechanisms of its cross-species transfer and current animal-independent spread.
In addition, I maintain an active interest in genetic determinants of drug resistance in the malarial parasite Plasmodium falciparum, following on from my earlier studies in this area.

Service Activities
Dr. Uhlemann serves as an Attending Physician on the Infectious Diseases Service at New York Presbyterian Hospital.

Positions & Appointments
2012- Assistant Professor of Medicine Columbia University Medical Center New York, NY
2010-2011 Instructor, Department of Medicine Columbia University Medical Center New York, NY


Education and Training
1993-1999 Medicine Eberhard-Karls-University, Tubingen, Germany
1999-2001 Clinical researcher, Tropical Medicine Eberhard-Karls-University, Tubingen, Germany
2002-2005 PhD studies, Molecular Parasitology St. George's Hospital, University of London, London, UK
2005-2007 Internship and Residency, Internal Medicine Columbia University Medical Center, New York, NY
2007-2010 Fellowship, Infectious Diseases Columbia University Medical Center, New York, NY

Honors and Awards
Paul A. Marks Scholarship, Columbia University

Selected Publications:
1. Uhlemann AC, Hafer C, Miko BA, Sowash MG, Sullivan SB, Shu Q, Lowy FD. (2013) Emergence of sequence type 398 as a community- and healthcare-associated methicillin-susceptible staphylococcus aureus in northern Manhattan. Clin Infect Dis. 57(5)::700-3

2. Uhlemann AC, Porcella SF, Trivedi S, Sullivan SB, Hafer C, Kennedy AD, Barbian KD, McCarthy AJ, Street C, Hirschberg DL, Lipkin WI, Lindsay JA, Deleo FR, Lowy FD. (2012) Identification of a Highly Transmissible Animal-Independent Staphylococcus aureus ST398 Clone with Distinct Genomic and Cell Adhesion Properties. mBio 3(2):pii: e00027-12

3. Uhlemann AC, Knox J, Miller M, Hafer C, Vasquez G, Ryan M, Vavagiakis P, Shi Q, Lowy FD. (2011) The environment as an unrecognized reservoir for community-associated methicillin resistant Staphylococcus aureus USA300: a case-control study. PLoS One 6(7):e22407

4. Hafer C, Lin Y, Kornblum J, Lowy FD, Uhlemann AC. (2012) Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 56(11):5845-51

5. Uhlemann AC, McGready R, Ashley EA, Brockman A, Singhasivanon P, Krishna S, White NJ, Nosten F, Price RN. (2007) Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J Infect Dis 195(1):134-41

6. Price RN*, Uhlemann AC*, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S., *Co-first authors. (2004) Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364(9432):438-47

 
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