Ann Marie Schmidt, MD - Department of Surgery

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Ann Marie Schmidt, MD

Positions and Appointments
2003-present		Gerald and Janet Carrus Professor of Surgical Science
2003-present		Columbia University College of Physicians & Surgeons, New York, NY
2003-present		Professor, Division of Surgical Science, Department of Surgery
2003-present		Columbia University College of Physicians & Surgeons, New York, NY
2002-present		Chief, Division of Surgical Science, Department of Surgery
2002-present		Columbia University Medical Center, New York, NY

Clinical Specialties

Internal medicine
Hematology
Oncology

Research Interests

Basic and translational research: RAGE and mechanisms linked to diabetes, cancer, inflammation and neurodegenerative diseases

Education and Training
1990-1993		Post-Doctoral Research Fellow, Department of Physiology and Cellular Biophysics (Laboratory of Dr. David M. Stern)
1990-1993		Columbia University College of Physicians & Surgeons, New York, NY
1983-1990		Teaching Assistant, Internal Medicine
1983-1990		New York University School of Medicine, New York, NY
1989-1990		Fellow, Medical Oncology
1989-1990		New York University Medical Center/Bellevue Hospital Center, New York, NY
1988-1989		Fellow, Hematology
1988-1989		New York University Medical Center/Bellevue Hospital Center, New York, NY
1987-1988		Chief Resident, Internal Medicine
1987-1988		New York University Medical Center/Bellevue Hospital Center, New York, NY
1984-1987		Resident, Internal Medicine
1984-1987		New York University Medical Center/Bellevue Hospital Center, New York, NY
1983-1984		Intern, Internal Medicine
1983-1984		New York University Medical Center/Bellevue Hospital Center, New York, NY
1983		MD
1983		New York University School of Medicine, New York, NY
1979		BA, Biology and History
1979		New York University, New York, NY

Board Certifications

Internal Medicine, American Board of Internal Medicine, 1988

Professional Experience

1998-2003		Associate Professor, Division of Surgical Science, Department of Surgery (with tenure)
1998-2003		Columbia University College of Physicians & Surgeons, New York, NY
1995-1998		Assistant Professor, Department of Surgery
1995-1998		Columbia University College of Physicians & Surgeons, New York, NY
1993-1998		Assistant Professor, Department of Medicine
1993-1998		Columbia University College of Physicians & Surgeons, New York, NY

Professional Honors

Phi Beta Kappa, 1978
Summa Cum Laude, New York University, 1979
Alpha Omega Alpha, 1982
Juvenile Diabetes Foundation Fellowship, 1990-1992
Harold and Golden Lamport Prize for Excellence in Clinical Research,
Columbia University, 1998
Recipient, Burroughs Wellcome Fund Clinical Scientist Award
in Translational Research, 1999
Schunk Prize for Medicine, 1999, Justus-Liebig University, Giessen, Germany
Mary Jane Kugel Award, Juvenile Diabetes Research Foundation International, 2003

Professional Societies and Committees

MEMBERSHIPS, PROFESSIONAL SOCIETIES

American Diabetes Association
American Heart Association, Thrombosis Council
American Society of Clinical Investigation
Society for Neuroscience
American Association for Cancer Research

SELECTED COMMITTEES

1998-Reviewer, National Insitutes of Health, Request for Applications: "Pathogenesis and Therapy of Diabetic Complications"

1999-Member, Vascular Biology I Study Section, American Heart Association

2000-2005 Member, NIH/DRG National Institutes of Aging: Biology of Aging - B

2000-Member, NIH Advisory Committee, Use of FY2001 Balanced Budget Act Funds for Type 1 Diabetes Research

2000-2002 Member, Juvenile Diabetes Foundation International Medical Science Research Committe: Group III: Complications

2002-Member, NIH/NIDDK Advisory Committee, Use of Special Congressional Funds for Type 1 Diabetes Research

2002-2005 Chair, Biology of Aging Study Section, NIA-B

2004-Special Emphasis Panel, National Institute of Diabetes and Digestive and Kidney Diseases, RFA DK-03-019 "Bench to Bedside Research on type 1 diabetes and its complications"

2004-Special Review Committee, National Heart Lung & Blood Institute, Program Project Application Review

Current Projects

RAGE and vascular dysfunction - Analysis of the contribution of RAGE, a cell-surface receptor that exacerbates inflammation and damage when activated, to heart disease-related vascular injury (particularly in diabetes).

RAGE and inflammatory/immune disorders -

RAGE and peripheral nerve injury/regeneration -

RAGE and neurodegenerative diseases -

RAGE and tumors -

Selected Publications

Basta, G., Schmidt, A.M., and DeCaterina, R. Advanced glycation endproducts and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovascular Research 63:582-592, 2004.

Wautier, J.L., and Schmidt, A.M. Protein glycation: a firm link to endothelial cell dysfunction. Circulation Research 95:233-238, 2004.

Hudson, B.I., and Schmidt, A.M. RAGE: a novel target for drug intervention in diabetic vascular disease. Pharmaceutical Research 21:1079-1086, 2004.

Yan, S.F., Ramasamy, R., Bucciarelli, L.G., Wendt, T., Lee, L.K., Hudson, B.I., Stern, D.M., Lalla, E., Yan, S.D., Rong, L.L., Naka, Y., and Schmidt, A.M. RAGE and its ligands: a lasting memory in diabetic complications? Diabetes Vascular Disease Research 1:10-20, 2004.

Naka, Y., Bucciarelli, L.G., Wendt, T., Lee, L.K., Rong, L.L., Ramasamy, R., Yan, S.F., and Schmidt, A.M. RAGE Axis. Animal Models and Novel Insights into the Vascular Complications of Diabetes. Arteriosclerosis, Thrombosis and Vascular Biology 24:1342-1349, 2004

Arumugam, T., Simeone, D.M., Schmidt, A.M., and Logsdon, C.D. S100P stimulates cell proliferation and survival via RAGE. Journal of Biological Chemistry 279:5059-5065, 2004.

Harja, E., Bucciarelli, L.G., Lu, Y., Stern, D.M., Zou, Y.S., Schmidt, A.M., and Yan, S.F. Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation. Circulation Research 94:333-339, 2004.

Cellek, S., Qu, W., Schmidt, A.M., and Moncada, S. Synergistic action of advanced glycation endproducts and endogenous nitric oxide leads to neuronal apoptosis in vitro: a new insight into selective nitrergic neuropathy in diabetes. Diabetologia 47:331-339, 2004

Zeng, S., Feirt, N., Goldstein, M., Guarrera, J., Ippagunta, N., Ekong, U., Dun, H., Lu, Y., Qu, W., Schmidt, A.M., and Emond, J.C. Blockade of receptor for advanced glycation end products (RAGE) attenuates ischemia and reperfusion injury to the liver in mice. Hepatology 39:422-432, 2004.

Li, J.H., Wang, W., Huang, X.R., Oldfield, M., Schmidt, A.M., Cooper, M.E., and Lan, H.Y. Advanced Glycation Endproducts induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. American Journal of Pathology 164:1389-1397, 2004.

Hwang, Y.C., Kaneko, M., Bakr, S., Liao, H., Lu,Y., Lewis, E.R., Yan, S.D., Ii, S., Itakura, M., Rui, L., Skopicki, H., Homma, S., Schmidt, A.M., Oates, P.J., Szabolcs, M., and Ramasamy, R. Central role for aldose reductase pathway in myocardial ischemic injury. In press, FASEB Journal, 2004.

Wear-Maggitti, K., Lee, J., Conejero, A., Schmidt, A.M., Grant, R., and Breitbart, A. Use of topical sRAGE in diabetic wounds increases neovascularization and granulation tissue formation. Annals Plastic Surgery 52:519-521, 2004.

Fujita, T., Asai, T., Andrassy, M., Stern, D.M., Pinsky, D.J., Zou, Y.S., Okada, M., Naka, Y., Schmidt, A.M., and Yan, S.F. PKC beta regulates ischemia/reperfusion injury in the lung. Journal of Clinical Investigation 113:1615-1623, 2004.

Liliensiek, B., Weigand, M.A., Bierhaus, A., Nicklas, W., Kasper, M., Hofer, S., Plachky, J., Grone, H.J., Kurschus, F.C., Schmidt, A.M., Yan, S.D., Martin, E., Schleicher, E., Stern, D.M., Hammerling, G.G., Nawroth, P.P., and Arnold, B. Receptor for advanced glycation endproducts (RAGE) regulates sepsis but not the adaptive immune response. Journal of Clinical Investigation 113:1641-1650, 2004.

Hou, F.F., Ren, H., Owen, W.F., Jr., Guo, Z.J., Chen, P.Y., Schmidt, A.M., Miyata, T., and Zhang, X. Enhanced expression of receptor for advanced glycation endproducts in chronic kidney disease. Journal American Society Nephrology 15:1889-1896, 2004.

Shaw, S.S., Schmidt, A.M., Banes, A.K., Wang, X., Stern, D.M., and Marrero, M.B. S100B-RAGE-mediated augmentation of angiotensin II-induced activation of JAK2 in vascular smooth muscle cells is dependent on PLD2. Diabetes 52:2381-2388, 2003.

Cipollone, F., Iezzi, A., Fazia, M., Zucchelli, M., Pini, B., Cuccurullo, C., De Cesare, De Blasis, G., Murano, R., Bei, R., Chiarelli, F., Schmidt, A.M., Cuccurullo, F., and Mezzetti, A. The Receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation 108:1070-1077, 2003.

Deane, R., Du Yan, S., Submamaryan, R.K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., Zhu, H., Ghiso, J., Frangione, B., Stern, A., Schmidt, A.M., Armstrong, D.L., Arnold, B., Liliensiek, B., Nawroth, P., Hofman, F., Kindy, M., Stern, D., and Zlokovic, B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9:907-913, 2003.

Zhou, Z., Wang, K., Penn, M.S., Marso, S.P., Lauer, M.A., Forudi, F., Zhou, X., Qu, W., Lu, Y., Stern, D.M., Schmidt, A.M., Lincoff, A.M., and Topol, E.J. Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury. Circulation: 107:2238-2243, 2003.

Yan SF, Ramasamy R, Naka Y, Schmidt AM. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 2003 Dec 12;93(12):1159-69.

Qu W, Lu Y, Lee L, Stern DM, Naka Y, Ramasamy R, Yan SD, Yan SF, D'Agati V, Schmidt AM. Blockade of receptor for advanced glycation endproducts: a new target fortherapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys. 2003 Nov 1;419(1):80-8. Review.

Joseph KP, Liu L, Qu W, Schnabel FR, Schmidt A. Soluble receptor for advanced glycation endproducts (sRAGE) effectively reduces tumor growth as a single agent and in combination with doxorubicin in a spontaneous mammary tumor model. J Surg Res. 2003 Oct;114(2):251.

Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, Lu Y, Papapanou PN, Schmidt AM. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1405-11. Epub 2003 Jun 19.

Wendt T, Tanji N, Guo J, Hudson BI, Bierhaus A, Ramasamy R, Arnold B, Nawroth PP, Yan SF, D'Agati V, Schmidt AM. Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy. J Am Soc Nephrol. 2003 May;14(5):1383-95. Review.

Wendt TM, Tanji N, Guo J, Kislinger TR, Qu W, Lu Y, Bucciarelli LG, Rong LL, Moser B, Markowitz GS, Stein G, Bierhaus A, Liliensiek B, Arnold B, Nawroth PP, Stern DM, D'Agati VD, Schmidt AM. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol. 2003 Apr;162(4):1123-37.

Sakaguchi T, Yan SF, Yan SD, Belov D, Rong LL, Sousa M, Andrassy M, Marso SP, Duda S, Arnold B, Liliensiek B, Nawroth PP, Stern DM, Schmidt AM, Naka Y. Central role of RAGE-dependent neointimal expansion in arterial restenosis. J Clin Invest. 2003 Apr;111(7):959-72.

Yan SD, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFaille J, Chess L, Stern DM, Jiang H. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med. 2003 Mar;9(3):287-93. Epub 2003 Feb 24.

INVITED ARTICLES/CHAPTERS/REVIEWS/ABSTRACTS:

Kim, W., and Schmidt, A.M. S100-stimulated sumoylation of RAGE: a mechanism to trigger activation of NF-kB. Diabetes 53 (Supplement #2): #1857-P, A443, 2004.

Toth, C.C., Schmidt, A.M., Tuor, U., Kaur, J., Zochodne, D.W., Foniok, T., Hoyte, L., Brussee, V., Barber, P., and Buchan, A. A model of diabetic cerebral white matter disease in mice: neuroimaging, histology and linkage to RAGE expression. Abstract #P02.093, American Academy of Neurology, 2004.

Sparrow, J.R., Cai, B., Zhou, J., Kim, S., Pachydaki, S.I., Nakanishi, K., and Schmidt, A.M. HNE-adducts, AGEs, RAGE and VEGF in blue-light irradiated A2E-laden RPE. Investigative Ophthalmology Visual Sciences 45: E-Abstract, #1807, 2004.

Tari, S.R., Lee, S.E., Tseng, J.J., Onat, D., Pachydaki, S.I., Horig, H., Noroziewicz, D.N., Yan, S.F., Schmidt, A.M., and Barile, G.R. Blockade of RAGE suppresses hypoxia-induced Egr-1 expression in the retina. Investigative Ophthalmology Visual Sciences 45: E-Abstract, #1049, 2004.

Guo, J., Qu, W., Lu, Y., Ramasamy, R., D’Agati, V., Schmidt, A.M., and Wendt, T. Blockade of RAGE suppresses adriamycin-induced oxidant stress in the kidney in BALB/c mice. J. Am. Soc. Nephrol. 14:554A, 2003.

Lee, L., Bucciarelli, L., Hwang, Y.C., Bakr, S., German, R., Wendt, T., Qu, W., Lu, Y., Schmidt, A.M., and Ramasamy, R. RAGE-dependent signaling in mononuclear phagocytes and endothelial cells generate oxidant stress and influences cardiac ischemic injury in diabetes. Circulation (Supplement IV): Abstract 968, IV-204, 2003.

Andrassy, M., Harja, E., Liu, K., Zou, Y.S., Belov, D., Yan, S.D., Schmidt, A.M., and Yan, S.F. Central role for the PKCß/egr-1 axis in neointimal expansion after acute arterial injury. Circulation (Supplement IV): Abstract 326, IV-70, 2003.

Harja, E., Lu, Y., Zou, S., Hudson, B.I., Schmidt, A.M., and Yan, S.F. Central roles for PKCß/early growth response-1 (egr-1) axis in atherosclerosis in apolipoprotein E null mice. Circulation (Supplement IV): Abstract 1429, IV-301, 2003.

Yan, S.F., Wendt, T., Qu, W., Liu, K., and Schmidt, A.M. Upregulation of egr-1 in hypoxic stress: central role of RAGE-dependent mechanisms. Circulation (Supplement IV): Abstract 1378, IV-290, 2003.

Rong, L.L., Yan, S.F., Adebayo, A., Lu, Y., Hays, A.P., Trojaborg, W., and Schmidt, A.M. RAGE-dependent signaling in peripheral neurons and macrophages regulates peripheral nerve repair. Society for Neuroscience 32nd Annual Meeting #552.1., 2003.

Lee, L.K., Song, F., and Schmidt, A.M. Laser doppler imaging of vascular reactivity in mice. 89th Annual Clinical Congress Abstract, American College of Surgeons, 2003.

Giacona, M.B., Papapanou, P.N., Lamster, I.B., Schmidt, A.M., and Lalla, E. Determinants of foam cell formation by human monocyte-derived macrophages infected with Porphyromonas gingivalis. Journal of Dental Research 82 (Spec. Issue B): p. 28, #123, 2003

Lalla, E., Lamster, I.B., Brandt, J.S., Guo, T., Yan, S.F., and Schmidt, A.M. Accelerated alveolar bone loss in diabetic mice over-expressing monocyte RAGE. Journal of Dental Research 82 (Spec. Issue B): p. 27, #118, 2003.

Tari, S.R., Pachydaki, S.I., Lee, S.E., Schiff, W.M., Chang, S., Schmidt, A.M., and Barile, G.R. S100/calgranulin and RAGE expression in PDR and PVR. Scientific Poster. Investigative Ophthalmology Visual Sciences 44: E-Abstract, #3039, 2003

Pachydaki, S.I., Tari, S.R., Donmoyer, C.M., Lai, K., Lee, S.E., Schmidt, A.M., and Barile, G.R. Electrophysiologic findings in a murine model of diabetes. Scientific Poster. Investigative Ophthalmology Visual Sciences 44: E-Abstract, #3873, 2003.

Moser, B., Wendt, T.M., Ankersmit, J.H., Hofmann, M., Bucciarelli, L.G., Hudson, B.I., Schuster, M., Goova, M.T., Szabolcs, M.J., Schmidt, A.M., and Itescu, S. Blockade of Receptor for AGE (RAGE) suppresses lymphocyte proliferation in mixed lymphocyte culture. J Heart Lung Transplantation 23 (1S), #82, 2003.

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