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Department of Medicine
Department of Medicine

Address:
Irving Cancer Research Center ( Audubon III )
1130 St. Nicholas Avenue
New York, NY   10032

Phone: 212 851-4582
Fax: 212 851-4590
aa819@columbia.edu

Affiliations
-Department of Medicine
-Institute of Human Nutrition
-Division of Digestive and Liver Diseases
-Celiac Disease Center

Open Training Positions
Graduate Students
Post-Doctoral Fellows


Armin Alaedini, PhD
Assistant Professor

Research Summary
Investigation of the link between the immune response to dietary or microbial antigens and the development of inflammatory processes affecting the gastrointestinal and nervous systems.

Research Activities
Armin Alaedini's laboratory pursues a multidisciplinary approach that includes proteomics, immunology, biochemistry, and molecular biology to study the link between the immune response to dietary or microbial antigens and the development of inflammatory mechanisms affecting the gastrointestinal and nervous systems. We are primarily focused on conducting translational research for the identification of novel biomarkers and understanding of disease mechanism, particularly in the context of celiac disease, autism, Lyme disease, and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Funding for research in our laboratory is currently provided by the National Institutes of Health, the Department of Defense, and The Stanley Medical Research Institute.

Positions & Appointments
2011-Present Assistant Professor, Dept. of Medicine Columbia University Medical Center New York, NY
2011-Present Assistant Professor, Institute of Human Nutrition Columbia University Medical Center New York, NY


Honors and Awards
Irving Institute/Clinical Trials Office Study Award (2012)
Department of Defense Research Program Concept Award (2010)
National Ataxia Foundation Young Investigator Award (2005)
American Neurological Association Fellowship Award (2000)

Selected Publications:
1. Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A. (2016) Epitope-specific evolution of human B cell responses to Borrelia burgdorferi VlsE protein from early to late stages of Lyme disease. J Immunol 196:1036-43.

2. Huebener S, Tanaka CK, Uhde M, Zone JJ, Vensel WH, Kasarda DD, Beams L, Briani C, Green PH, Altenbach SB, Alaedini A. (2015) Specific nongluten proteins of wheat are novel target antigens in celiac disease humoral response. J Proteome Res 14:503-11.

3. Tang KS, Klempner MS, Wormser GP, Marques A, Alaedini A. (2015) Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not post-treatment Lyme disease syndrome. Clin Infect Dis 61:1703-6.

4. Ajamian A, Kosofsky B, Wormser GP, Rajadhyaksha AM, Alaedini A. (2013) Serologic markers of Lyme disease in children with autism. JAMA 309:1771-3.

5. Lau NM, Green PH, Taylor AK, Hellberg D, Ajamian M, Tan CZ, Kosofsky B, Higgins J, Rajadhyaksha AM, Alaedini A. (2013) Markers of celiac disease and gluten sensitivity in children with autism. PLoS ONE 8:e66155.

6. Jacek E, Fallon BA, Chandra A, Crow MK, Wormser GP, Alaedini A. (2013) Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. J Neuroimmunol 255:85-91.

7. Chandra A, Latov N, Wormser GP, Marques AR, Alaedini A. (2011) Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome. Clin Immunol 141:103-110.

8. Samaroo D, Dickerson F, Kasarda DD, Green PHR, Briani C, Yolken RH, Alaedini A. (2010) Novel immune response to gluten in individuals with schizophrenia. Schizophr Res. 118:248-55.

9. Alaedini A, Okamoto H, Briani C, Wollenberg K, Shill H, Bushara KO, Sander HW, Green PH, Hallett M, Latov N. (2007) Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I. J Immunol 178:6590-5.

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