Armin Alaedini's laboratory utilizes a multidisciplinary approach that includes proteomics, immunology, biochemistry, and molecular biology to study host-microbe interactions and the role of microbial and dietary antigens in immune-mediated mechanisms affecting the gastrointestinal (GI) and nervous systems. Our research is focused on the following areas:
Research Area 1 – Inflammatory response to dietary and microbial antigens in the context of GI and neuropsychiatric disease—investigating the gut-immune-brain connection.
Human intestinal mucosal surfaces are colonized by large communities of microorganisms and are in constant contact with an abundance of highly immunogenic dietary and microbial components. Proper regulation of the interaction between the host and the contents of the GI tract is of utmost importance in avoiding aberrant immune responses and requires several different mechanisms. Failure of one or more of these regulatory mechanisms can adversely affect human health, not only through GI disorders, but also in the context of systemic manifestations that may influence cognition and behavior. A primary focus of our group is investigation of the gut-immune-brain connection and the role of intestinal inflammation in the context of GI and neuropsychiatric disease. Our research is currently funded by the National Institutes of Health, the Department of Defense, and the Stanley Medical Research Institute.
Research Area 2 – Mechanisms and biomarkers of post-infection persistence of inflammation and symptoms.
There is evidence that persistence of rheumatic and neurocognitive symptoms after antibiotic treatment of certain infections can be immune-mediated. A critical barrier to a better understanding of the mechanisms involved has been the lack of biomarkers to characterize disease phenotypes and analyze treatment outcome. Our laboratory is conducting studies to understand the connection between the bacterial strain genotype in specific infections, host immune response, and the persistence of inflammation and symptoms following antibiotic treatment. Our work is also aimed at establishing a panel of biomarkers for identifying affected individuals and predicting the outcome of patients with active infection in regard to their risk of developing post-treatment symptoms.
Positions & Appointments
||Assistant Professor, Dept. of Medicine
||Columbia University Medical Center
||New York, NY
||Assistant Professor, Institute of Human Nutrition
||Columbia University Medical Center
||New York, NY
Honors and Awards
Department of Defense CDMRP Idea Award (2014)
Irving Institute/Clinical Trials Office Study Award (2012)
Department of Defense CDMRP Concept Award (2010)
National Ataxia Foundation Young Investigator Award (2005)
American Neurological Association Travel Fellowship Award (2000)
Committees and Society Memberships
American Association of Immunologists; Member
American Gastroenterological Association; Member
American Academy of Neurology; Member
American Chemical Society; Member
N. American Society for the Study of Celiac Disease; Treasurer and Member
New York Academy of Sciences; Member
1. Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green PH, Verna EC, Volta U, Alaedini A. (2016) Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut
2. Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A. (2016) Epitope-specific evolution of human B cell responses to Borrelia burgdorferi VlsE protein from early to late stages of Lyme disease. J Immunol
3. Huebener S, Tanaka CK, Uhde M, Zone JJ, Vensel WH, Kasarda DD, Beams L, Briani C, Green PH, Altenbach SB, Alaedini A. (2015) Specific nongluten proteins of wheat are novel target antigens in celiac disease humoral response. J Proteome Res
4. Galipeau HJ, McCarville JL, Huebener S, Litwin O, Meisel M, Jabri B, Sanz Y, Murray JA, Jordana M, Alaedini A, Chirdo FG, Verdu EF. (2015) Intestinal microbiota modulates gluten-induced immunopathology in humanized mice. Am J Pathol
5. Tang KS, Klempner MS, Wormser GP, Marques A, Alaedini A. (2015) Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not post-treatment Lyme disease syndrome. Clin Infect Dis
6. Ajamian A, Kosofsky B, Wormser GP, Rajadhyaksha AM, Alaedini A. (2013) Serologic markers of Lyme disease in children with autism. JAMA
7. Lau NM, Green PH, Taylor AK, Hellberg D, Ajamian M, Tan CZ, Kosofsky B, Higgins J, Rajadhyaksha AM, Alaedini A. (2013) Markers of celiac disease and gluten sensitivity in children with autism. PLoS ONE
8. Jacek E, Fallon BA, Chandra A, Crow MK, Wormser GP, Alaedini A. (2013) Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. J Neuroimmunol
9. Samaroo D, Dickerson F, Kasarda DD, Green PHR, Briani C, Yolken RH, Alaedini A. (2010) Novel immune response to gluten in individuals with schizophrenia. Schizophr Res.
10. Alaedini A, Okamoto H, Briani C, Wollenberg K, Shill H, Bushara KO, Sander HW, Green PH, Hallett M, Latov N. (2007) Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I. J Immunol