Wellington V Cardoso
Wellington V Cardoso
Medicine (& Genetics and Development)

Address: BB -8-812
Phone: 212-342-3971


Education and Training:
M.D. 1981, Univesrity of Brasilia (Brazil)
Ph.D. 1989, University of Sao Paulo (Brazil)
bullet  Department of Medicine, Center for Human Development
bullet  Department of Genetics and Development
Training Activities:
Research Summary:
(800 words, max)
The regulation of lung progenitor cell fate during lung development.
Current Research:
Research in the Cardoso’s lab focuses on the mechanisms that regulate lung progenitor cell fate during lung development and on the contribution of developmental mechanisms to disease pathogenesis and regeneration-repair of the adult lung. We are investigating how progenitor cells generate the wide diversity of cell types of the mature respiratory system. In this context, we have been identifying early markers of cell fate and characterizing the genetic programs associated with acquisition of the various airway epithelial cell phenotypes as the lung forms. These studies have provided insights into the role of specific pathways, including retinoids, Fgf, Tgf beta and Notch in controlling the specification and expansion of lung progenitors, airway branching and differentiation of the various lung epithelial cell lineages. Over these years our studies have evolved to continue exploring basic mechanisms of lung development, using this knowledge to understand the role of stem/progenitor cells in lung regeneration-repair and the impact of prenatal fetal exposures in adult lung structure and function and susceptibility to disease.
(6 max)
1. Chen, F. and Cardoso, WV.: Culture of Mouse Embryonic Foregut Explants  Springer New York,  2014,  163-169

2. Mahoney, JE, Mori, M, Szymaniak, AD, Varelas, X and Cardoso, WV.: (2014) The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors.  Developmental Cell  30; Issue 2: 137-150

3. Lu, J, Izvolsky, KI, Qian, J and Cardoso, WV.: (2005) Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.  J. Biol Chem   280:: 4934-4841

4. Cardoso, WV and Lu, J. : (2006) Regulation of early lung development: questions, facts and controversies.  Development  133: 1161-1624

5. Desai T, Chen F., Lu J, Qian J, Niederreither K., Dollé, P., Chambon, P., and Cardoso WV: (2006) Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.  Dev. Biol  291: 12-24

URL for lab page: