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Wayne Frankel, Ph.D.
Professor


Address: 701 W 168th St HHSC Rm 611A (office) Rm 610 (lab) New York NY 10032
Phone: 12123054435
Fax:
E-mail:

wf2218@cumc.columbia.edu

Education and Training:
Bachelor of Arts, Biology 1978-1982, University of Pennsylvania
Ph.D., Genetics 1982-1987, Albert Einstein College of Medicine
Postdoctoral studies 1987-1992, Tufts University School of Medicine
Affiliations:
bullet  Genetics and Development Department
bullet  Institute for Genomic Medicine
Training Activities:
Research Summary:
(800 words, max)
My research is devoted to understanding the genetic basis of neurological disorders with an emphasis on epilepsy and a growing interest in closely related synaptic disorders that include seizures, such as autism and intellectual disability.
Current Research:
My focus is on better modeling epilepsy at the physiological and molecular level using a multidisciplinary approach - genetics, genomics, cell biology and biochemistry - in genes encoding ion channels, synaptic molecules, RNA binding proteins and others. We are currently modeling severe pediatric epileptic encephalopathies in laboratory mice. Much of our research is part of a multi-platform close collaboration with other members of the Institute for Genomic Medicine (IGM), towards development of precision medicine-based novel therapies.

I also provide oversight in mouse genetics, genomics and biology for the IGM as its director of preclinical models, and am the program director of the Mouse Neurobehavioral Core (MNBC), to open in 2017

Publications:
(6 max)
1. Asinof S, Mahaffey C, Beyer B, Frankel WN, Boumil R. : (2016) Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy..  Neurobiology of Disease  95: 1-11

2. Asinof SK, Sukoff Rizzo SJ, Buckley AR, Beyer BJ, Letts VA, Frankel WN, Boumil RM.: (2015) Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an
Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.  PLOS Genetics  11: e1005347

3. Wagnon JL, Briese M, Sun W, Mahaffey CL, Curk T, Rot G, Ule J, Frankel WN.: (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including
genes associated with regulation of synaptic function.  PLOS Genetics  8: e1003067

4. Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J, Frankel WN: (2013) Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.  Journal of Physiology  591: 241-255

5. Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT, Frankel WN: (2011) Etiology of a genetically complex seizure disorder in Celf4 mutant mice.  Genes, Brain and Behavior  10: 765-777

6. Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.: (2010) A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.  PLOS Genetics  6: e1001046

URL for lab page:
 http://igm.columbia.edu

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