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Richard S. Mann
Richard S. Mann
Higgins Professor of Biochemistry and Molecular Biophysics
and Systems Biology


Address: 701 West 168th Street Room 1104 New York NY 10032
Phone: 212-305-7731
Fax: 212-305-7924
E-mail:

rsmann10@gmail.com

Education and Training:
Ph.D. 1986, MIT
Postdoctoral Fellow 1986-1990, Stanford University
Affiliations:
bullet  Department of Biochemistry and Molecular Biophysics
bullet  Department of Systems Biology
bullet  Integrated Program in Cellular Molecular and Biophysical Studies
Training Activities:
bullet  Department of Genetics and Development
Research Summary:
(800 words, max)
Control of pattern formation by homeotic genes and their downstream targets in Drosophila.
Current Research:
We use the fruit fly, Drosophila melanogaster, to study animal development.

Four projects are currently active in the lab:

1. How the Hox family of homeodomain transcription factors target and specifically regulate the correct sets of target genes during development.
2. How the proximal-distal axis of the appendages are established.
3. How the motor neurons that innervate the adult legs develop.
4. Dissection of the neural circuitry used for coordinated walking by adult flies.

For more details, see http://themannlab.org
Computer annotation of fTIR (frustrated Total Internal Reflection) signal used to track fly footprints while walking
Publications:
(6 max)
1. Crocker J, Abe N, Rinaldi L, McGregor AP, Frankel N, Wang S, Alsawadi A, Valenti P, Plaza S, Payre F, Mann RS, Stern DL.: (2015) Low affinity binding site clusters confer hox specificity and regulatory robustness.  Cell  160: 191-203

2. Slattery M, Voutev R, Ma L, Nčgre N, White KP, Mann RS.: (2013) Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning.  PLOS Genetics  e1003753: doi: 10.1371/journal.pgen.1003753

3. Baek M, Enriquez J, Mann RS: (2013) Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila.  Development  140: 2027-38

4. Mendes CS, Bartos I, Akay T, Márka S, Mann RS.: (2013) Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster.  eLife  2: e00231

5. Agelopoulos M, McKay DJ, Mann RS.: (2012) Developmental regulation of chromatin conformation by Hox proteins in Drosophila.  Cell Reports  1: 350-9

6. Estella C, Voutev R, Mann RS.: (2012) A dynamic network of morphogens and transcription factors patterns the fly leg..  Curr Top Dev Biol.  98: 173-98

URL for lab page:
 http://themannlab.org

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