Rodney Rothstein
Professor of Genetics and Development

Address: 701 West 168th Street Room 1608 New York NY 10032
Phone: 212-305-1733
Fax: 212-923-2090


Education and Training:
Ph.D. 1975, University of Chicago
Postdoctoral Fellow 1975-1977, University of Rochester
Postdoctoral Fellow 1977-1979, Cornell University
bullet  Department of Genetics and Development
bullet  Institute of Cancer Genetics
Training Activities:
bullet  Department of Genetics and Development
bullet  Integrated Program in Cellular, Molecular and Biophysical Studies
Research Summary:
(800 words, max)
Yeast genetics and cell biology cellular responses to DNA damage; recombination; control of genome stability.
Current Research:
By using budding yeast as an experimental organism, we are able to study essential biological processes such as the mechanisms underlying the recognition and repair of DNA damage. The role that genetic recombination plays during repair is an integral part of our research.

We are exploring the biological response to DNA damage by studying a central recombination protein, Rad52, a ribonuclease reductase inhibitor that responds degrades after DNA damage, Sml1, and a topoisomerase helicase complex necessary for resistance to DNA damaging agents, Top3/Sgs1.

The availability of a complete gene disruption library is another tool that aids our research. By developing methods to enhance the utility of this resource, we are facilitating genome-wide analysis of not only budding yeast, but other species as well.
(6 max)
1. Alvaro, D.A., Lisby, M. and Rothstein, R: (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.  PLos Genetics  10.1371: 0030228

2. Barlow, J.H., Lisby, M. and Rothstein, R: (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1.  Molecular Cell  30: 73-85

3. Reid, R.J.D., Sunjevaric, I., Voth, W.P., Ciccone, S., Du, W., Olsen, A.E., Stillman, D.J. and Rothstein, R: (2008) Chromosome-scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae chromos.  Genetics  180: 1799-1808

4. Barlow, J.H. and Rothstein, R: (2009) Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase.  EMBO Journal  28: 1121-1130

5. Thorpe, P.H., Bruno, J. and Rothstein, R: (2009) Kinetochore asymmetry defines a single yeast lineage.  Proc. Natl. Acad. Sci. USA  106: 6673-6678

6. Burgess, R.B., Lisby, M., Altmannova, V., Krejci, L., Sung, P. and Rothstein, R: (2009) Localization of recombination proteins and Srs2 reveals antirecombinase function in vivo.  J. Cell Biology  185: 969-981

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