 |
|
|
Riccardo Dalla-Favera
|
Professor & Director, Institute for Cancer Genetics
Uris Professor of Pathology
|
| Address: |
1130 St. Nicholas Avenue Irving Comprehensive Research Center, ICRC Room 508A New York NY 10032 |
| Phone: |
212-851-5273 |
| Fax: |
212-851-5256 |
E-mail:
|
rd10@columbia.edu
|
|
|
Education and Training:
|
M.D. 1976, University of Milan
|
|
Affiliations:
|
 Institute for Cancer Genetics
Department of Genetics and Development
|
|
Training Activities:
|
|
|
Research Summary:
(800 words, max)
|
Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia; genetic control in lymphoid tissue development. |
|
Current Research:
|
The development of many types of cancer is due to genetic lesions involving proto-oncogenes and tumor suppressor genes. It is well established that multiple lesions must occur in a cell before cancer can develop. The general goal of this laboratory is to identify the lesions and the genes involved in the development of human B cell lymphoma, to determine the mechanism by which these lesions occur and to elucidate the contribution of each lesion to tumor development.
Specific lines of investigation include:
(1) Elucidating the role of chromosomal translocations involving the c-myc proto oncogene locus and immuno-globulin loci in the development of Burkitt's lymphoma. These studies include the analysis of the mechanisms regulating the expression of the normal c-myc gene as well as of c-myc alleles structurally altered by chromosomal translocation in lymphoma cells.
(2) Studying the normal and pathologic function of the BCL-6 gene, a recently identified proto-oncogene which codes for a transcription factor expressed in B cells and is altered in its regulatory region in a significant fraction of human lymphoma.
(3) Identifying novel oncogenes and tumor suppressors involved in the pathogenesis of lymphoma by virtue of their involvement in tumor-associated chromosomal translocations or by "positional cloning" from chromosomal regions involved in tumor-associated deletions. |
|
Publications:
(6 max)
|
1. Basso, K., Klein, U., Niu, H., Stolovitzky G.A., Tu, Y., Califano, A., Cattoretti, G., and Dalla-Favera, R.: (2004) Tracking CD40 signaling during germinal center development. Blood 104 (13): 4088-4096
2. Basso, K., Liso, A., Tiacci, E., Benedetti, R., Pulsoni, A., Foa, R., Di Raimondo, F., Ambrosetti, A., Califano, A., Klein, U., Dalla-Favera, R., Falini, B.: (2004) Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. J. Exp. Med 199 (1): 59-68
3. Küppers, R., U. Klein, I. Schwering, V. Distler, A. Bräuninger, G. Cattoretti, Y. Tu, G.A. Stolovitzky, A. Califano, M.-L. Hansmann, and R. Dalla-Favera. : (2003) Identification of Hodgkin and Reed-Sternberg Cell-Specific Genes by Gene Expression Profiling. J. Clin. Invest 111: 529-537
4. Klein, U., Tu, Y., Stolovitzky, G.A., Keller, J.L., Haddad Jr., J., Miljkovic, V., Cattoretti, G., Califano, A., Dalla-Favera, R. : (2003) Transcriptional Analysis of the B-Cell Germinal Center Reaction. Proc. Acad. Natl. Sci. U.S.A 100: 2639-2644
5. Klein, U., Gloghini, A., Gaidano, G., Chadburn, A., Cesarman, E., Dalla-Favera, R., Carbone, A.: (2003) Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood 101: 4115-4121
6. Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A., Dalla-Favera, R. : (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogenous phenotype related to memory B cells. J. Exp. Med 97: 2098-2104
|
|
URL for lab page:
|
|
|
|
