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Riccardo  Dalla-Favera
Riccardo Dalla-Favera
Professor & Director, Institute for Cancer Genetics
Uris Professor of Pathology


Address: 1130 St. Nicholas Avenue Irving Comprehensive Research Center, ICRC Room 508A New York NY 10032
Phone: 212-851-5273
Fax: 212-851-5256
E-mail:

rd10@columbia.edu

Education and Training:
M.D. 1976, University of Milan
Affiliations:
bullet  Institute for Cancer Genetics
bullet  Department of Genetics and Development
Training Activities:
Research Summary:
(800 words, max)
Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia; genetic control in lymphoid tissue development.
Current Research:
The development of many types of cancer is due to genetic lesions involving proto-oncogenes and tumor suppressor genes. It is well established that multiple lesions must occur in a cell before cancer can develop. The general goal of this laboratory is to identify the lesions and the genes involved in the development of human B cell lymphoma, to determine the mechanism by which these lesions occur and to elucidate the contribution of each lesion to tumor development.

Specific lines of investigation include:

(1) Elucidating the role of chromosomal translocations involving the c-myc proto oncogene locus and immuno-globulin loci in the development of Burkitt's lymphoma. These studies include the analysis of the mechanisms regulating the expression of the normal c-myc gene as well as of c-myc alleles structurally altered by chromosomal translocation in lymphoma cells.

(2) Studying the normal and pathologic function of the BCL-6 gene, a recently identified proto-oncogene which codes for a transcription factor expressed in B cells and is altered in its regulatory region in a significant fraction of human lymphoma.

(3) Identifying novel oncogenes and tumor suppressors involved in the pathogenesis of lymphoma by virtue of their involvement in tumor-associated chromosomal translocations or by "positional cloning" from chromosomal regions involved in tumor-associated deletions.
Publications:
(6 max)
1. Cattoretti, G., Pasqualucci, L., Ballon, G., Tam, W., Nandula, S.V., Shen, Q., Mo, T., Murty, V.V., Dalla-Favera, R: (2005) Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B-cell lymphomas in mice.  Cancer Cell  7: 445-455

2. Dominguez-Sola, D., Ying, CY., Grandori, C., Ruggiero, L., Chen, B., Galloway, DA., Gu, W., Gautier, J., Dalla-Favera, R. : (2007) Non-transcriptional control of DNA replication by c-myc.  Nature  448: 445-451

3. Saito, M., Gao, J., Basso, K., Kitagawa,Y., Smith, PM., Pasqualucci, L., Dalla-Favera, R: (2007) A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma.  Cancer Cell  12: 280-292

4. Klein, U., Dalla-Favera, R: (2008) Germinal centres: role in B-cell physiology and malignancy.  Nature Rev. Immunology  8: 22-33

5. ompagno, M., Lim, W.K., Grunn, A., Nandula, S.V., Brahmachary, M., Shen, Q., Bertoni, F., Ponzoni, M., Scandurra, M., Califano, A., Bhagat, G., Chadburn, A., Dalla-Favera, R. and Pasqualucci, L: (2009) Mutations of multiple genes cause deregulation of the NF-kB pathway in diffuse large B-cell lymphoma.  Nature  459: 717-721

6. Klein, U., Lia, M., Crespo, M., Siegel, R., Shen, Q., Mo, T., Ambesi-Impiombato, A., Califano, A., Migliazza, A., Bhagat, G., Dalla-Favera, R: (2010) The DLEU2/miR-15a/16-1 cluster controls B-cell proliferation and its deletion leads to chronic lymphocytic leukemia.  Cancer Cell  17(1): 28-40

URL for lab page:
 

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