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Jean  Gautier
Jean Gautier
Professor, Genetics & Development


Address: 1130 St. Nicholas Avenue ICRC Room 603A New York NY 10032
Phone: 212-851-4564
Fax: 212-851-5284
E-mail:

jg130@columbia.edu

Education and Training:
Ph.D. 1983, Toulouse University
Dr. Sc. 1988, Toulouse University
Postdoctoral Fellowship 1988-89, University of Colorado Health Science Center
Postdoctoral Fellowship 1989-92, UC San Francisco
Affiliations:
bullet  Department of Genetics and Development
bullet  Herbert Irving Comprehensive Cancer Center
bullet  Insitute for Cancer Genetics
Training Activities:
bullet  Integrated Program in Cellular, Molecular and Biophysical Studies
Research Summary:
(800 words, max)
The main objective of our research is to better understand the molecular mechanisms responsible for the maintenance of genome stability. These controls are lost in cancer, which is characterized by genomic instability.
Current Research:
Specifically, we are studying:
1. The mechanism of DNA double-strand break (DSB) repair, in particular the early processing events that are critical to determine repair pathway choice. We utilize biochemical approaches in cell-free extracts derived from the eggs of the vertebrate, Xenopus laevis, proteomics analysis as well as small molecules that regulate the response to DSBs.
2. The mechanism(s) of DNA Inter-strand Crosslink (ICL) repair. These lesions are generated by several classes of successful chemotherapeutic drugs. Understanding signaling from these lesions and their modes of repair is critical to develop more effective compounds and to circumvent resistance.
3. DNA replication stress and DNA damage resulting from oncogene activation. We are focusing on the case of c-Myc
Publications:
(6 max)
1. *Dominguez-Sola D., *Ying C., Grandori C., Ruggiero L., Chen B., Galloway D., Gu W., *Gautier J. and *Dalla-favera R: (2007) Non-transcriptional control of DNA replication by c-Myc.  Nature  448: 445-451

2. *Dupre A., *Boyer-Chatenet L., Sattler RM., Modi A., Lee JH., Nicolette M., Kopelovich L., Jasin M., Baer R., Paull T. and Gautier J: (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-RAD50-Nbs1 complex.  Nature Chem. Biol  4: 119-125

3. Dupre A., Boyer-Chatenet L. and Gautier J.: (2006) Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex..  Nat. Struct. Mol. Biol.   13: 451-457

4. Peterson S., Li Y., Chait B., Baer R., Gottesman M. and Gautier J. : (2011) Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.  J. Cell Biol.   194: 705-720

5. Ben-Yehoyada M., Wang L.C., Kozekov I., Rizzo C., Gottesman M., and Gautier J.: (2009) Checkpoint signaling from a single DNA interstrand crosslink.  Molecular Cell  35: 704-715

6. Williams H., Gottesman M.E. and Gautier J. : (2012) Mechanism of replication-independent interstrand crosslink repair.  Molecular cell. In press.  

URL for lab page:
 http://www.gautierlab.org/

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