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Joseph Terwilliger
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Associate Professor of Neuroscience and Genetics and Development
Adjunct Professor, Helsinki University
Adjunct Professor, Yanbian University of Science & Technology
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622 West 168th Street PH 18-302 New York NY 10032 |
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E-mail:
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joseph.terwilliger.@helsinki.fi
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Education and Training:
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Ph.D. 1993, Columbia University
Postdoctoral Fellow 1993-1996, Columbia University
Postdoctoral Fellow 1994-1996, University of Oxford
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Affiliations:
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 Department of Genetics and Development
Department of Medical Genetics
Columbia Genome Center
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Training Activities:
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Department of Genetics and Development
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Research Summary:
(800 words, max)
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Population genetic epidemiology and gene mapping. |
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Current Research:
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My research is focused on development and application of computer software for statistical genetics applications including software for joint linkage and linkage disequilibrium analysis on arbitrarily large pedigrees (Pseudomarker) and software for assisting in the study design process for linkage and linkage disequilibrium analysis (Detectance) - in collaboration with researchers at the University of Helsinki; and software for simulating the evolution of phenogenetic relationships on a genome-wide scale under various models of mutation, selection, and population demographics (ForSim) in collaboration with researchers at Penn State University.
Additionally I am involved in study design and data analysis from numerous field studies in Kazakhstan, Finland, Korea, Venezuela, Mongolia, Russia, China, and Sweden among others. In furtherance of the latter applied aims, I organize and teach workshops on "Logical Reasoning in Human Genetics" in various places throughout the developing world, where the potential human genetic resources far surpass what we could ever hope to accomplish in cosmopolitan western societies like our own." |
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Publications:
(6 max)
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1. Hennah W, Tomppo L, Hiekkalinna T, Palo OM, Kilpinen H, Ekelund J, Tuulio-Henriksson A, Silander K, Partonen T, Paunio T, Terwilliger JD, Lonnqvist J, Peltonen L.: (2007) Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet 16(5): 453-462
2. Kaunisto MA, Kallela M, Hamalainen E, Kilpikari R, Havanka H, Harno H, Nissila M, Sako E, Ilmavirta M, Liukkonen J, Teirmaa H, Tornwall O, Jussila M, Terwilliger J, Farkkila M, Kaprio J, Palotie A, Wessman M.: (2006) Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. Cephalalgia 26(12): 1462-1472.
3. Anttila V, Kallela M, Oswell G, Kaunisto MA, Nyholt DR, Hamalainen E, Havanka H, Ilmavirta M, Terwilliger J, Sobel E, Peltonen L, Kaprio J, Farkkila M, Wessman M, Palotie A.: (2006) Trait components provide tools to dissect the genetic susceptibility of migraine. Am J Hum Genet 79(1): 85-99
4. Terwilliger JD, Hiekkalinna T.: (2006) An utter refutation of the "Fundamental Theorem of the HapMap". Eur J Hum Genet 14(4): 426-437.
5. Li Z, Szabolcs M, Terwilliger JD, Efstratiadis A.: (2006) Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene. Carcinogenesis 27(5): 1054-1067
6. Hiekkalinna T, Terwilliger JD, Sammalisto S, Peltonen L, Perola M.: (2005) AUTOGSCAN: powerful tools for automated genome-wide linkage and linkage disequilibrium analysis. Twin Res Hum Genet 8(1): 16-21
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URL for lab page:
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http://linkage.cpmc.columbia.edu/ |
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