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Iva  Greenwald
Iva Greenwald
Professor, Department of Biochemistry and Molecular Biophysics
Professor, Department of Genetics and Development


Address: 701 West 168th Street Room 720A New York NY 10032
Phone: 212-305-6928
Fax: 212-1721
E-mail:

isg4@columbia.edu

Education and Training:
Ph.D. 1982, M.I.T.
Postdoctoral Fellow 1983-1986, MRC Lab of Molecular Biology
Affiliations:
bullet  Department of Biochemistry and Molecular Biophysics
bullet  Department of Genetics and Development
bullet  Integrated Program in Cellular, Molecular and Biophysical Studies
bullet  Howard Hughes Medical Institute
Training Activities:
bullet  Department of Genetics and Development
bullet  Department of Biochemistry and Molecular Biophysics
bullet  Integrated Program in Cellular, Molecular and Biophysical Studies
Research Summary:
(800 words, max)
Cell-cell interactions, signal transduction, and cell fate choice; genetic and molecular studies of C. elegans development.
Current Research:
LIN-12/Notch is the receptor component of one of the major signaling systems for specifying cell fate during animal development. In addition, mutations in core components and modulators of the LIN-12/Notch pathway have been implicated in cancer, Alzheimer's disease, and other diseases and syndromes. We use genetic approaches in C. elegans to study how LIN-12/Notch signaling is modulated during normal development and potential ways it may be modulated in disease.

In our current work, we aim to understand the fundamental logic and molecular events that govern cell-cell interactions and cell fate decisions. Areas of interest include the identification of modes and mechanisms of crosstalk between LIN-12/Notch and EGF receptor or Insulin/Insulin-like growth factor signaling, and the interplay between cell cycle and LIN-12/Notch activity in development. We also use sensitive and specific suppressor and enhancer screens in C. elegans to identify new modulators of LIN-12/Notch activity. Recently, we have primarily focused on identifying and characterizing negative modulators that are conserved in mammals.
Publications:
(6 max)
1. Karp, X. and Greenwald, I.: (2013) Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans .  Proc. Natl. Acad. Sci.  110: 2181-2186

2. Greenwald, I. and Kovall, R.: (2013) Notch signaling: genetics and structure.  WormBook   : doi: 10.1895/wormbook.1.10.2.

3. de la Cova, C. and Greenwald, I.: (2012) SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.  Genes & Dev.  26 :  2524-2535

4. Greenwald, I.: (2012) Notch and the awesome power of genetics.  Genetics  191: 655-669

5. Shaye, D.D. and Greenwald, I.: ( 2011) OrthoList: a compendium of C. elegans genes with human orthologs.  PLoS One   6:  e20085

6. Zhang, X. and Greenwald, I.: (2011) Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans.  Genetics    188:  847-858

URL for lab page:
 http://www.greenwaldlab.org/

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