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Angela  Christiano
Angela Christiano
Associate Professor of Molecular Dermatology


Address: 1150 St. Nicholas Ave., Russ Berrie Pavillion, Room 303B New York NY 10032
Phone: 212-851-4850
Fax: 212-851-4810
E-mail:

amc65@columbia.edu

Education and Training:
Ph.D. 1991, Rutgers University
Postdoctoral Fellow 1991-1995, Jefferson Medical College
Affiliations:
bullet  Department of Dermatology
bullet  Department of Genetics and Development
bullet  Stem Cell Consortium
Training Activities:
bullet  Integrated Program in Cellular, Molecular and Biophysical Studies
bullet  MD/PhD Program
bullet  Training Program in Genetics and Development
Research Summary:
(800 words, max)
Molecular basis of inherited skin and hair disorders in humans and mice.
Current Research:
The major focus of our research is the study of inherited skin and hair disorders in humans and mice, through a classical genetic approach including identification and phenotyping of disease families, genetic linkage, gene discovery and mutation analysis, and functional studies relating these findings to basic questions in epidermal biology. Our interests include transcriptional regulation of hair cycling and differentiation, the biology of cadherin-mediated cell adhesion junctions known as desmosomes, and the morphogenesis epidermal appendages such as hair and teeth. A long-range goal of our research is to develop genetic and cell-based therapies for skin and hair diseases through understanding disease pathogenesis. We are using epithelial reprogramming as a therapeutic approach for inherited skin diseases.
Publications:
(6 max)
1. Ahmad, W., ul Haque, M.F., Brancolini, V., Tsou, H.C., ul Haque, S., Lam, H.M., Aita, V.M., Owen, J., deBlaquiere, M., Frank, J.A., Cserhalmi-Friedman, P.B., Leask, A., McGrath, J., Peacocke, M., Ahmad, M., Ott, J. and Christiano, A.M. : (1998) Alopecia Universalis Associated with a Mutation in the Human hairless Gene.  Science  279: 720-724

2. Frank, J., Pignata, C., Panteleyev, A.A., Prowse, D.M., Baden, H., Weiner, L., Gaetaniello, L., Ahmad, W., Pozzi, N., Cserhalmi-Friedman, P.B., Aita, V.M., Uyttendaele, H., Gordon, D., Ott, J., Brissette, J.L. and Christiano, A.M. : (1999) Exposing the Human Nude Phenotype .  Nature  398: 473-474

3. Reynolds, A.J., Lawrence, C., Cserhalmi-Friedman, P.B., Christiano, A.M. and Jahoda, C.A.B.: (1999) Trans-gender Induction of Hair Follicles.  Nature  402: 33-34

4. Djabali, K., Aita, V,M, and Christiano, A.M. : (2001) Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix.  J. Cell Science  114: 367-376

5. Panteleyev, A.A., Jahoda, C.A.B. and Christiano, A.M.: (2001) Hair Follicle Predetermination.  J. Cell Science   114: 3419-3431

6. Kljuic, A., Bazzi, H., Sundberg, J.P., Martinez-Mir, A., O'Shaughnessy, R., Mahoney, M.G., Levy, M., Montagutelli, X., Ahmad, W., Aita, V.M.,Gordon, D., Uitto, J., Whiting, D., Ott, J., Fischer, S., Gilliam, T.C., Jahoda, C.A.B., Morris, R.J., Panteleyev,: (2003) Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris.  Cell  113: 249-260

URL for lab page:
 

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